"Research on the genome of traditional Chinese medicine has great strategic and practical significance. Currently, the development of traditional Chinese medicine has encountered two major shortcomings. One of them is the decline in the quality of medicinal materials after they are converted from wild to domestically grown. Therefore, genetic research and transformation of medicinal materials is the general trend."
7 On March 2, Zhang Boli, honorary president of the China Academy of Chinese Medical Sciences and academician of the Chinese Academy of Engineering, appeared at the Chengdu University of Traditional Chinese Medicine to deliver a speech at the press conference of the "Thousand Herbal Genomes Project".
For a long time, due to the lack of genome information of the original plants of traditional Chinese medicine, there has been a lack of communication bridges between traditional Chinese medicine and modern life sciences. Emerging cutting-edge life science technologies have been difficult to apply to traditional Chinese medicine research, seriously restricting the development of traditional Chinese medicine. Further development.
"From human genomics to disease genomics, genomics has promoted the progress of modern life sciences, clinical sciences, and pharmacy, and is the foundation for promoting medical progress. I think that after the completion of herbal genomics, it will also contribute to the modernization and industrialization of traditional Chinese medicine. As well as bringing fundamental changes and promotion to the modernization of traditional Chinese medicine. "
It is understood that the "Thousand Herbal Genomes Project" will provide new varieties of medicinal plants, synthetic biology and in-situ protection and relocation of endangered medicinal plants. Provide basic data support for the development of land protection, promote the application of cutting-edge life science technologies in the field of medicinal plants and traditional Chinese medicine, achieve leap-forward development of medicinal plants and traditional Chinese medicine research, and help them quickly move to the forefront of life science research.
Press conference site
Traditional Chinese Medicine Gene Resources
Precious national strategic resources
"We will be based on medicinal plant species collected in the pharmacopoeias of China, India, the European Union, the United States, Japan, South Korea, Brazil , Egypt and other countries. , systematically collected and organized thousands of medicinal plant resources, built a physical library, and completed the genome sequencing of more than 1,000 medicinal plants..."
Academician Chen Shilin , leader of the "Thousand Herbal Genome Project", introduced that with the development of modern science, The industry's understanding of traditional Chinese medicine has gradually transitioned from early experience accumulation to the application of modern science and technology to conduct in-depth research on traditional Chinese medicine. However, the understanding of the genetic resources of traditional Chinese medicine plants is very weak, which will restrict the protection of Chinese medicine plant resources and the breeding of new varieties in my country. , biosynthesis of medicinal ingredients, and research on the establishment of medicinal plant model species systems.
"The implementation of the 'Thousand Herbal Genome Project' is the only way to modernize traditional Chinese medicine, which is to solve the problems in traditional Chinese medicine research by interpreting the biological mechanisms of traditional medicines, obtaining genome and gene genetic information , and conducting research and development on gene functions. A series of difficulties are faced, including: establishing a medicinal model organism system for research on the biosynthesis and regulation of secondary metabolites, producing important natural drugs or new drug raw materials through synthetic biology, and using genome-assisted breeding to cultivate Chinese herbal medicines. Excellent varieties, developing molecular markers for identifying counterfeit Chinese medicinal materials, revealing the authentic biological nature of medicinal materials, establishing a herbal database to protect precious medicinal plant genetic resources, etc.”
Throughout China and abroad, Chinese medicinal genetic resources are abundant. It is a precious national strategic resource. "The international competition situation is severe. South Korea, the United States, Japan and other countries have launched full-genome research on many basic species of traditional Chinese medicine, posing a great challenge to the field of traditional Chinese medicine research in my country."
It is understood that genes and genomes are important in modern traditional Chinese medicine research. One of the strategies is to conduct research on the biogenetic background of traditional Chinese medicine, which is expected to break through the global problems faced by the modern pharmaceutical industry such as resource waste and depletion, environmental pollution and destruction, and realize the green, recyclable and sustainable development and utilization of traditional Chinese medicine to become traditional Chinese medicine in the 21st century. The primary issue of modernization development, returning to the biological research of the basic species of traditional Chinese medicine will also become the driving force to promote the leap-forward development of traditional Chinese medicine.
The "Thousand Herbal Genomes Project" proposed
promoting the gene safety of Chinese herbal medicines as a national strategic security
At the scene, Zhang Boli commented that the genome database of thousands of medicinal plants in the "Thousands of Herbal Genomes Project" will promote the gene safety of Chinese herbal medicines as a national strategic security strategic security."Through genomics research, we can study the authenticity of traditional Chinese medicine and reveal the active substances, synthesis rules and mechanisms of action of authentic medicinal materials . The research can also be transformed into high-quality traditional Chinese medicine seed sources, which can be It is of practical significance to explore the use of medicinal materials and reclassify the distribution map of authentic medicinal materials, especially the artificial cultivation of endangered Chinese medicinal materials. These are the benefits that herbal genomics may bring."
Zhang Boli
President of Chengdu University of Traditional Chinese Medicine Yu Shuguang. said that as the country’s first national key discipline of traditional Chinese medicine and a “double first-class” traditional Chinese medicine discipline construction university, Chengdu University of Traditional Chinese Medicine has always been committed to the research and exploration of traditional Chinese medicine resources and modernization of traditional Chinese medicine. Resources State Key Laboratory and National Chinese Medicine Germplasm Resource Bank. The "Thousands of Materia Medica Genome Project" led by Academician Chen Shilin will promote the in-depth integration of medicinal plants and traditional Chinese medicine fields with cutting-edge life science and technology, achieve leap-forward integration and development in the field of medical research, and make contributions to the implementation of the "Healthy China" strategy. new contribution.
In the future, the "Thousand Herbal Genomes Project" will complete the genome assembly of thousands of medicinal plants, build an international scientific alliance for medicinal plant genome research, establish China's leading position in the field of international medicinal plant genomes, and establish model research on medicinal plants. system to promote research on the synthesis, regulation and transportation of active ingredients of medicinal plants; establish a genome database of thousands of medicinal plants to promote the genetic safety of medicinal plants as national strategic security; build a living resource nursery and seed bank of thousands of medicinal plants ; Promote the breeding of new high-quality herbal medicine varieties and the biosynthesis of active ingredients.
Red Star News reporter Liu Kejun
editor Chen Yixi
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