erectile dysfunction ED and premature ejaculation PE are two completely independent diseases, so the treatment drugs are different, ED with sildenafil, tadalafil, vardenafil and the recently marketed . Varnafil and other phosphodiesterase-5 inhibitors are the mainstays, while PE is the main serotonin reuptake inhibitor and dapoxetine.
When ED and PE appear in the same person, can avanafil be taken with dapoxetine for PE at the same time?
Let me talk about the answer first: Yes, but be careful.
1. There is no pharmacological conflict between avanafil and dapoxetine
avanafil is a phosphodiesterase-5 inhibitor, by inhibiting phosphodiesterase-5 To increase the relaxation of smooth muscles, congestion of guanosine cyclophosphate, and thus play a role in assisting erection. Dapoxetine acts to delay the reabsorption of serotonin by inhibiting neurons. From the point of view of pharmacology , avanafil and dapoxetine have different mechanisms of action, and there will be no pharmacological conflicts when used in combination.
2. There is no interaction between avanafil and dapoxetine
According to the [interaction] item in the instructions, the main drugs that interact with the action of avanafil are Nitrate drugs, alpha receptor blockers, antihypertensive drugs, strong and moderate CYP3A4 inhibitors, etc., serotonin reuptake inhibitors are not among them.
In addition, the [interaction] item in the instructions of dapoxetine mentioned that it was combined with phosphodiesterase-5 inhibitor sildenafil and tadalafil, and it was found that tadalafil did not affect Dapoxetine pharmacokinetics.Sildenafil can slightly change the pharmacokinetics of dapoxetine, but this effect has no clinical significance.
3. Chinese expert consensus: a combination of phosphodiesterase-5 inhibitors and dapoxetine can be used to treat ED and PE comorbidities
The expert consensus is mainly composed of well-known experts in related fields. The results of a consensus on the diagnosis and treatment of specific clinical problems. In the "Consensus of Chinese Experts on the Diagnosis and Treatment of Comorbidity of Premature Ejaculation and Erectile Dysfunction", multiple clinical trials have confirmed that for patients with ED/PE at the same time, when the effect of monotherapy is not satisfactory, the combined use of phosphodiesterase- 5 Inhibitors and dapoxetine can exert the therapeutic effect together, which is better than single-agent treatment.
In summary, avanafil can be used in combination with dapoxetine, but it must be evaluated by a doctor and used according to doctor's advice.
Will taking avanafil and dapoxetine at the same time increase side effects?
also pointed out in the "Chinese Expert Consensus on the Diagnosis and Treatment of Comorbidity of Premature Ejaculation and Erectile Dysfunction" that the combination of phosphodiesterase-5 inhibitor and dapoxetine did not increase the risk of adverse reactions.
According to clinical trial observations, the most common adverse events of dapoxetine and phosphodiesterase-5 inhibitors include nausea, headache, dizziness, diarrhea, palpitation, etc., no adverse events of orthostatic hypotension have been observed. Most adverse events have only a slight impact on the condition, and drug metabolism or symptomatic treatment can alleviate or improve.
Finally, the male pharmacist would like to remind the male pharmacist to pay attention to the things that should be paid attention to when taking avanafil and dapoxetine at the same time:
1. There are concurrent contraindications to either avanafil or dapoxetine. People, do not take it;
2, Dapoxetine and avanafil should be taken more than 1 hour apart;
3. Pay attention to the onset time of both,The onset time of dapoxetine is about 1 to 3 hours, and the onset time of avanafil is about 15 to 30 minutes.
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.Reference:
Premature Ejaculation and Erectile Dysfunction Complications Diagnosis and Treatment Chinese Expert Consensus Compilation Group, Zhang Zhichao. Premature Ejaculation and Erection Chinese expert consensus on diagnosis and treatment of dysfunction comorbidities[J]. Chinese Journal of Andrology, 27(5):6.
