[124] On March 16, 2022, Lu Cewu of Shanghai Jiao Tong University and Kay M. Tye of Howard Hughes Medical Institute in the United States jointly published a research paper titled "Cortical ensembles orchestrate social competition through hypothalamic outputs" in Nature online. Th

2022 has ended and 2023 has begun. On this occasion, the iNature editorial department counted Chinese scholars in 2022 Nature and Science The number of publications, a total of 267 , is summarized:

• divided by magazine, Chinese scholars published Nature papers 160 papers , Science papers 107 articles ;
• divided by units, Chinese Academy of Sciences ranked first published a total of 68 articles , Tsinghua University has 27 articles, Peking University has 21 articles, Zhejiang University has 20 articles, Nanjing University has 12 articles, University of Science and Technology of China has 12 articles, Fudan University has 9 articles, Hong Kong University 8 articles ;
• according to whether there are foreign units. Cooperation, Sino-foreign cooperation has 132 articles, 135 of which are mainly completed by Chinese units;
  
• is divided according to the number of corresponding units, there are only 74 articles with one corresponding author, and there are 193 articles with more than one corresponding author;
• is divided by corresponding author: Pan Jianwei has 5 articles , Chai Jijie has 4 articles , Zhu Min has 4 articles, Xu Huaqiang has 3 articles, Li Gong has 3 articles, Sun Jinpeng has 2 articles, Han Zhifu has 2 articles, Chang Junbiao has 2 articles, Huang Sanwen has 2 articles, Chen Zhucheng has 2 articles, Gao Fu has 2 articles, Yuan Guoyong has 2 articles, Xie Xiaoliang has 2 articles, Shi Yigong has 2 articles , etc.
• is divided according to fields: life sciences (the proportion is at least more than half) and materials science fields are more numerous.

Due to the rush of time, if there are any errors, please leave a message to inform the editorial department so that we can correct it as soon as possible. At the same time, we deeply apologize for any errors.

Summary of 267 research results published by Chinese scholars in Nature and Science in 2022:

[1-75] On December 12, 2022, the iNature editorial department summarized 75 articles published by Chinese scholars in Nature from July 1, 2022 to December 12, 2022 (Click to read);

[76] On June 29, 2022, Harbin Institute of Technology Li Hui , Xu Xiang and UCLA Duan Xiangfeng jointly communicated in Nature published online titled "Hypocrystalline ceramic aerogels for thermal insulation at extreme conditions" research paper, which reports the multiscale design of subcrystalline zircon nanofiber aerogels with zigzag structures, enabling excellent thermomechanical stability and ultra-low thermal conductivity at high temperatures. The combination of thermomechanical and thermal insulation properties provides attractive material systems for robust insulation in extreme conditions ( click to read).

【77】 On June 29, 2022, Ma Jinbiao of Fudan University and Wang Hongwei of Tsinghua University jointly published an online publication titled "Structural insights into dsRNA processing by Drosophila" in Nature Dicer-2–Loqs-PD” research paper, which reports cryo-EM structures of Dcr-2–Loqs-PD in the apo state and in various states when processing a 50 bp dsRNA substrate. This study reveals the molecular mechanism by which Dcr-2-Loqs-PD carries out the full cycle of ATP-dependent dsRNA processing (Click to read).

【78】 On June 29, 2022, Axel Behrens from the Institute of Cancer Research, London, UK (Li Huafu from Sun Yat-sen University is the co-first author) published a research paper titled "GREM1 is required to maintain cellular heterogeneity in pancreatic cancer" online in Nature . The research combined the BMP inhibitor GREM1 Identified as a key regulator of cell heterogeneity in human and mouse pancreatic cancer. Sustained inhibition of BMP activity by is critical for the maintenance of epithelial PDAC cells, suggesting that continuous paracrine signaling initiated by a single soluble factor is required to maintain the cellular heterogeneity of pancreatic cancer ( Click to read).

[79] On June 21, 2022, Tsinghua University Ding Sheng, Liu Kang and Ma Tianhua jointly published a research paper titled "Induction of mouse totipotent stem cells by a defined chemical cocktail" in Nature . This study demonstrated the use of three small molecules Combination of TTNPB, 1-Azakenpaulllone and WS6 on TotiSCs from mouse pluripotent stem cells (PSCs) induction and long-term maintenance. The chemical methods used in this study to induce and maintain TotiSCs provide a clear in vitro system to manipulate and understand the totipotent state to create life from non-reproductive cells (Click to read).

[80] June 17, 2022, Peking University Xie Xiaoliang, Cao Yunlong, Xiao Junyu , Institute of Biophysics, Chinese Academy of Sciences Wang Xiangxi , China Institute of Food and Drug Control Wang Youchun and Nankai University Shen Zhongyang jointly communicated in Nature published a research paper online titled "BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection". This study combined with the comparison of spike protein structures shows that BA.2.12.1 and BA.4/BA.5 showed comparable ACd'jE2 binding affinities to BA.2. Taken together, these results suggest that Omicron may evolve mutations to evade humoral immunity caused by BA.1 infection, suggesting that BA.1-derived vaccine boosters may not achieve broad-spectrum protection against new Omicron variants (Click to read).

【81】 On June 15, 2022, Zheng Jian’s team from the Institute of Chemistry, Chinese Academy of Sciences published an online publication titled "Synthesis of a monolayer fullerene" in Nature "network" research paper, which prepared a large-sized single crystal two-dimensional carbon material through an interlayer bonding cleavage strategy, that is, a single layer of quasi-hexagonal phase fullerene (C60). This two-dimensional carbon material with a medium band gap and unique topology provides an interesting platform for potential applications in two-dimensional electronic devices (Click to read).

[82] On June 8, 2022, Gao Hongjun of the Institute of Physics of the Chinese Academy of Sciences and Wang Ziqiang of Boston College jointly published an online publication titled "Ordered and tunable Majorana-zero-mode lattice in naturally strained" in Nature LiFeAs" research paper, which reports the formation of an ordered and tunable Majorana zero-mode (MZM) lattice in naturally strained stoichiometric LiFeAs via scanning tunneling microscopy/spectroscopy. Taken together, the research results provide a path towards tunable and ordered MZM lattices as a future topological quantum computing platform ( click to read).

[83] On June 8, 2022, an international team led by Li Han of the National Astronomical Observatory of the Chinese Academy of Sciences published a research paper titled "A repeating fast radio burst associated with a persistent radio source " online in Nature. This study discovered the only persistently active repeating fast radio burst FRB to date. 20190520B.The above findings reveal that the complex environment around active repeating bursts has characteristics similar to ultra-bright supernova explosions, challenging the traditional view of FRB dispersion analysis, and laying the foundation for building an evolution model of fast radio bursts and understanding this violent and mysterious phenomenon in the universe ( click to read).

[84] On June 8, 2022, Huang Sanwen's team at the Shenzhen Institute of Agricultural Genomics, Chinese Academy of Agricultural Sciences, published a research paper titled "Genome evolution and diversity of wild and cultivated potatoes" online at Nature . The study assembled 24 wild germplasms and 20 cultivated germplasms. 44 high-quality diploid potato genomes from accessions representing the Solanum segment Petota (the tuber-bearing clade), as well as from adjacent segments 2 genomes of Etuberosum. Taken together, this research will accelerate the breeding of hybrid potatoes and enrich our understanding of the evolution and biology of potatoes as a global staple food crop ( Click to read).

[85] On June 8, 2022, Huang Sanwen's team at the Shenzhen Institute of Agricultural Genomics, Chinese Academy of Agricultural Sciences, published a research paper titled "Graph pangenome captures missing heritability and empowers tomato breeding" online in Nature . The study reported a tomato graph pangenome, which was accurately cataloged from 838 More than 19 million variants across genomes, including 32 new reference-level genome assemblies. In summary, This study advances the understanding of the heritability of complex traits and demonstrates the role of graph pangenomics in crop breeding ( click to read).

[86] On June 8, 2022, Jun Lu, Khalil Amine of Argonne National Laboratory and Pan Feng of Peking University jointly published an online publication titled " Origin of structural degradation in Li-rich layered oxide" in Nature cathode" research paper, which reveals that nanometer strains and lattice shifts accumulate during battery operation. These findings highlight the importance of lattice strain/displacement in causing voltage decay and will spur a wave of efforts to unlock the potential for large-scale commercialization of LMR cathode materials (Click to read).

[87] June 1, 2022, Wuhan University Liu Tiangang, University of Bonn Jeroen S. Dickschat and University of Tokyo Ikuro Abe jointly corresponded (Tao Hui, Lukas Lauterbach, Bian Guangkai, Dr. Chen Rong, Hou Anwei and Takahiro Mori are the co-first authors) in Nature published a research paper online titled "Discovery of non-squalene triterpenes", which investigated two fungal chimeric class I TrTS: Talaromyces The verruculosus talaropentaene synthase (TvTS) and the Macrophomina phaseolina macrophomene synthase (MpMS) were characterized. The findings identify a novel enzymatic mechanism for triterpene biosynthesis and enhance understanding of terpene biosynthesis in nature. This research subverts the long-standing inherent knowledge that "all triterpenoids are synthesized with squalene as the only starting unit" (click to read).

[88] On May 18, 2022, Wang Xingjun of Peking University and John E. Bowers of the University of California, Santa Barbara (Peking University is the first unit) jointly published an online publication titled "Microcomb-driven silicon photonic" in Nature systems" research paper, which combines these two technologies by using an energy-efficient and simple-to-operate aluminum-gallium-arsenide insulator microcomb source to drive a complementary metal-oxide-semiconductor SiPh engine. This synergy of microcombs and SiPh integrated components is an important step towards the next generation of fully integrated photonic systems ( click to read).

【89】 On May 18, 2022, the research group of Academician Huang Hefeng and ht The team of academician Xu Guoliang of the Center for Excellence in Molecular and Cell Science of the Chinese Academy of Sciences has made another important new discovery in the research of gametes/embryonic diseases, which was published in Nature on May 18, 2022. published an online article titled "Maternal inheritance of glucose intolerance through oocyte Tet3 The original research results of "insufficiency" answer the above questions. reveals for the first time the epigenetic mechanism of ovogenic adult diabetes, providing new ideas and perspectives for the exploration of embryogenic disease mechanisms. It also moves the prevention and control of adult chronic diseases to the gamete stage, providing new strategies for related disease intervention ( click to read).

[90] On May 12, 2022, the Peking University Yichengqi team published a research paper titled " Mitochondrial base editor induces substantial nuclear off-target mutations" online in Nature . This study shows that the mitochondrial base editor induces extensive off-target editing in the nuclear genome. 's genome-wide, unbiased analysis of its editome reveals hundreds of off-target sites that are either associated with or independent of TALE array sequences (TAS). Overall, the findings have implications for the use of DdCBE in basic research and therapeutic applications, and demonstrate the need to thoroughly define and evaluate off-target effects of base editing tools (Click to read).

[91] On May 11, 2022, University of New South Wales Li Sean and University of Hong Kong Lain-Jong Li jointly communicated ( University of New South Wales Huang Jingkai, Shi Junjie, Zhang Ji Wan Yi, University of Hong Kong) published online in Nature titled "High-κ perovskite membranes as insulators for two-dimensional transistors" research paper exploring the ultra-high κ of transferable Single-crystal perovskite strontium titanium oxide films serve as dielectric gates for 2D field-effect transistors. The perovskite film exhibits ideal sub-nanometer CET with low leakage current. The study found that the van der Waals gap between the strontium titanium oxide dielectric and the 2D semiconductor mitigates the adverse edge-induced barrier lowering effects that result from the use of ultra-high κ dielectrics (click to read).

[92] On May 11, 2022, Washington University School of Medicine Azad Bonni, Tongji University Zhang Xiaoqing and Princeton University Samuel Wang jointly published an online publication in Nature entitled "Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning” research paper, which isolated nuclei labeled in specific cell types and then performed single-nucleus RNA sequencing to analyze Purkinje neurons and map their responses to motor activity and learning. The findings define how the diversity of Purkinje neurons is linked to their responses in motor learning and provide a basis for understanding their differential vulnerability to neurological diseases (Click to read ).

[93] On May 11, 2022, Liu Chong's team from Zhejiang University published a research paper titled " Olfactory sensory experience regulates gliomagenesis via neuronal IGF1" online at Nature . This study showed that smell can directly regulate the occurrence of glioma. The findings establish a link between sensory experience and glioma development through their corresponding sensory neuron circuits (Click to read ).

[94] On May 4, 2022, Wang Xiaomu of Nanjing University, Shi Yi, University of Minnesota Tony Low and University of Electronic Science and Technology of China Li Xuesong jointly published an online publication in Nature titled "Observation of chiral and slow plasmons in twisted bilayer graphene" research paper, which reports the direct observation of two new plasmonic modes in macroscopic twisted bilayer graphene (tBLG) with a highly ordered Moiré superlattice. The findings reveal new electromagnetic dynamics of small-angle tBLG and exemplify it as a unique quantum optical platform (Click to read).

[95] On May 4, 2022, Nanjing University Wang Xinran , Li Taotao, Southeast University Wang Jinlan and Ma Liang jointly published an online publication titled "Uniform nucleation and epitaxy of bilayer molybdenum disulfide on Nature sapphire" research paper reporting the uniform nucleation of double-layered molybdenum disulfide (MoS2) on c-plane sapphire (99%). In short, these benchmark results show that dual-layer MoS2 is more suitable for high-performance transistor technologies other than silicon ( click to read).

【96】 On May 4, 2022, Benjamin List of the Max Planck Institute for Coal Research in Germany and Chinese University of Hong Kong Cheng Guijuan published an online publication titled "Organocatalytic stereoselective cyanosilylation of small" in Nature ketones" research paper, which reports the development of broadly applicable confined organocatalysts for the highly enantioselective cyanation of aromatic and aliphatic ketones, including the challenging 2-butanone. The work could encourage chemists to create catalysts that rival the remarkable and sometimes extreme selectivity observed with enzymes. Finally, the method developed in this study is expected to be used in the synthesis of natural products and drugs ( click to read).

[97] On May 4, 2022, Shan Libo, He Ping and Shandong Jianzhu University Hou Shuguo from Texas A&M University published an online publication in Nature entitled " Phytocytokine signaling reopens stomata in plant immunity and water loss” research paper demonstrating secreted peptides SMALL PHYTOCYTOKINES (SCREWs) and cognate receptor kinase PLANT SCREW that regulate defense and water loss UNRESPONSIVE RECEPTOR (NUT) regulates stomatal closure induced by the plant hormones abscisic acid (ABA) and microbe-associated molecular patterns (MAMPs). The SCREW-NUT system is widely distributed in land plants, suggesting that it plays an important role in preventing uncontrolled stomatal closure caused by abiotic and biotic stresses to optimize plant fitness ( click to read).

[98] On April 27, 2022, Wu Heng of Shenzhen University and Mazhar N. Ali of Delft University of Technology in the Netherlands published a research paper titled "The field-free Josephson diode in a van der Waals heterostructure" online. The research was made by manufacturing The inversion symmetry of NbSe2/Nb3Br8/NbSe2 destroys the van der Waals heterostructure to realize Josephson diodes. This non-reciprocal behavior strongly violates the known Josephson relationship and opens the door to the discovery of new mechanisms and physical phenomena through the integration of quantum materials with Josephson junctions, and provides a new approach to superconducting quantum devices ( click to read).

【99】 On April 27, 2022, the team of Professor Mao Youdong of Peking University published a research paper titled "USP14-regulated allostery of the human proteasome by time-resolved cryo-EM" online in Nature . This study demonstrated the human USP14 High-resolution cryo-EM structure of the 26S proteasome complexed with 13 different conformational states captured during degradation of polyubiquitinated proteins. These findings provide insights into the complete functional cycle of the USP14-regulated proteasome and lay the mechanistic basis for the discovery of USP14-targeted therapies(Click to read).

[100] On April 27, 2022, Huang Lusheng of Jiangxi Agricultural University, Chen Congying and Michel Georges jointly corresponded (Yang Hui and Wu Jinyuan) published online in Nature titled "ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs"'s research paper explores the impact of host genotype on the composition of the pig gut microbiota. The findings provide very strong evidence for the influence of host genotype on the abundance of specific bacteria in the gut, combined with insights into the molecular mechanisms supporting this association. They pave the way for the same effects to be found in human rural populations (click to read).

[101] On April 27, 2022, the team of Professor Chen Zhucheng of Tsinghua University published an online publication titled "Structure of human chromatin-remodelling PBAF complex bound to a" in Nature nucleosome" research paper, which reports the cryo-electron microscopy structure of PBAF complex bound to nucleosomes. Taken together, our findings provide mechanistic insights into nucleosome recognition by PBAF and provide a structural basis for understanding SMARCA4-related human diseases.(click to read).

【102】 On April 27, 2022, Liu Beibei and others from Zhejiang University published an online article titled "Early Solar System instability triggered by dispersal of the gaseous" in Nature disk"'s research paper, which uses dynamical simulations to show that the instability of giant planets may be triggered by the dispersion of gaseous disks. The growing number of Earth-like planets may even have been caused by its disturbance, explaining Mars' small mass relative to Earth ( Click to read).

[103] On April 27, 2022, Chen Chen-Hui’s team from Academia Sinica, Taiwan, published an online article titled "Skin cells undergo asynthetic fission to expand body surfaces in" in Nature Research paper by zebrafish, This study creates a multicolor cell membrane labeling system, palmskin, to monitor the entire superficial epithelial cell (SEC) population of developing zebrafish larvae. Global or local manipulation of integument growth affects the extent and pattern of SEC cleavage, possibly through tension-mediated stretch activation of ion channels ( Click to read).

[104] On April 27, 2022, Sarajo K. Mohanta and Andreas J. R. Habenicht of the University of Munich jointly corresponded (Peng Li of Guizhou University of Traditional Chinese Medicine is the co-first author) and published online in Nature titled "Neuroimmune cardiovascular interfaces control atherosclerosis" research paper, which hypothesizes that the peripheral nervous system may interact directly with diseased arteries. The peripheral nervous system uses NICI to assemble structural ABCs, and therapeutic intervention in ABCs reduces atherosclerosis (Click to read).

【105】On April 20, 2022, Xu Xiaodong from the University of Washington and Yao Wang from the University of Hong Kong jointly published an online publication titled "Light-induced ferromagnetism in moiré" in Nature superlattices" research paper, which reports that photoexcitation can highly tune the spin-spin interaction between moiré-trapped carriers, leading to the ferromagnetic ordering of the WS2/WSe2 moiré superlattice. This discovery adds a dynamic tuning knob to the rich many-body Hamiltonian of moiré quantum matter.

【106】 On April 13, 2022, Shenzhen BGI Life Sciences Research Institute cooperated with 35 scientific research teams from 6 countries including Beijing BGI Life Sciences Research Institute, Shenzhen National Gene Bank, Jilin University, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Karolinska Institutet of Sweden, Cambridge University in the UK, ICREA Research Institute in Spain, and ASTAR in Singapore. Liu Longqi, Xu Xun, Hou Yong and Miguel A. Esteban co-correspondence (Han Lei, Wei Xiaoyu, Liu Chuanyu, Zhuang Zhenkun, Zou Xuanxuan, Wang Zhifeng and GiacomoVolpe are the co-first authors of the paper) published online in Nature titled "Cell transcriptomic atlas of The non-human primate Macaca fascicularis" research paper presents a large-scale cellular transcriptome atlas containing more than 1 million cells from 45 tissues of adult NHP macaques. This dataset provides a large annotation resource to study species that are phylogenetically close to humans. To demonstrate the utility of the atlas, the study reconstructed the network of cell-cell interactions that drive Wnt signaling across the body and mapped the distribution of receptors and co-receptors for viruses that cause infectious diseases in humans. The study's macaque cell atlas constitutes an important reference for future research in humans and NHP (click to read).

【107】 On April 13, 2022, Deng Hongkui, Wang Jinlin of Peking University and Lu Shichun of the Chinese People's Liberation Army General Hospital jointly published an online publication in Nature titled "Chemical reprogramming of human somatic cells to pluripotent stem cells" research paper, which demonstrates the chemical reprogramming of human somatic cells into human chemically induced pluripotent stem cells that exhibit key characteristics of embryonic stem cells through the creation of an intermediate plasticity state via . This research lays the foundation for developing regenerative therapeutic strategies that use well-defined chemicals to alter human cell fate(click to read).

[108] On April 13, 2022, Wu Beili’s research group and Zhao Qiang’s research group at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and Shui Wenqing’s research group at Shanghai University of Science and Technology published an online publication in Nature titled "Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1" research paper, which has made breakthrough progress in the study of orphan receptor signal transduction mechanisms. This study successfully analyzed the three-dimensional structure of the complexes of two adhesion GPCRs, ADGRD1 and ADGRF1, that bind to G proteins respectively, and conducted in-depth functional correlation studies. elucidated the molecular mechanism of spontaneous activation of this type of orphan receptor for the first time, providing an important basis for studying the signal transduction mechanism of this type of receptor and future drug design (click to read).

【109】 On April 13, 2022, Yu Xiao and Sun Jinpeng of Shandong University, Kong Liangliang of the National Protein Center and Zhang Lei of Xi'an Jiaotong University jointly published an online publication in Nature entitled "Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4” research paper, which shows three cryo-electron microscopy structures of aGPCR of coupled to Gs heterotrimer. This study provides structural and biochemical insights into the mechanism of tethering activation of aGPCR (click to read).

[110] On April 13, 2022, Sun Jinpeng of Shandong University, Xu Huaqiang of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and Ines Liebscher of the Rudolf Schönheimer Institute in Germany jointly published an online publication titled " Structural basis for the tethered peptide activation of adhesion" in Nature GPCRs' research paper, reports the cryo-electron microscopy (cryo-EM) structures of two aGPCRs complexed with Gs: GPR133 and GPR114. This study structure reveals the detailed mechanism of Stachel sequence and its Gs coupling to activate aGPCR (Click to read).

[111] On April 13, 2022, Han Shuang of Jilin University, Ma En and Ding Xiangdong of Xi'an Jiaotong University, Sha Gang of Nanjing University of Science and Technology and Liao Xiaozhou of Sydney University jointly published an online publication titled "Uniting tensile ductility with ultrahigh strength via composition in Nature undulation" research paper, which proved that although the nanocrystalline nickel-cobalt solid solution is still a face-centered cubic single phase, its tensile strength is about 2.3 Gipascal, has considerable ductility, with an elongation at break of approximately 16%. Thus, the undulating landscape of resistance to dislocation propagation provides a strengthening mechanism to maintain tensile ductility ( click to read).

[112] On April 13, 2022, Zhu Hongmin of the University of Science and Technology Beijing and Tetsuya Nagasaka of Tohoku University jointly published an online publication titled "A solid-state electrolysis process for upcycling aluminum in Nature scrap” research paper that proposes a solid state electrolysis (SSE) process that uses molten salt to upcycle aluminum scrap. By using this efficient, low-energy process, true sustainability of the aluminum cycle can be envisioned (click to read).

[113] On April 13, 2022, Hanna K. A. Mikkola and Vincenzo Calvanese of the University of California, Los Angeles, co-corresponded (Ma Feiyang of the Chongqing International Institute of Immunology is the co-first author) published online in Nature titled "A solid-state electrolysis process for upcycling aluminum scrap" research paper, which creates single-cell transcriptome maps of human hematopoietic tissue from the first trimester to birth and finds that throughout pregnancy, HSC signaturesRUNX1+HOXA9+MLLT3+MECOM+HLF+SPINK2+ differentiates HSCs from progenitor cells. In vivo mapping of human hematopoietic stem cell ontogeny confirms the generation of aorta-gonad-mesonephros-like decisive hematopoietic stem and progenitor cells from human pluripotent stem cells and serves as a guide to promote their maturation toward functional hematopoietic stem cells.

【114】 On April 6, 2022, Xiao Bailong and Li Xueming of Tsinghua University jointly corresponded (Yang Xuzhong, Lin Chao, Chen Xudong, and Li Shouqing are the co-first authors) and published online in Nature titled "Structure deformation and curvature sensing of PIEZO1 in lipid membranes" research paper that determines the curved and flattened structures of PIEZO1 reconstituted in liposome vesicles, directly visualizes the remarkable deformability and flattened structure of the PIEZO1-lipid bilayer system at approximately 300 nm2 The in-plane area expands. This study therefore provides a fundamental understanding of how 's remarkable deformability and structural rearrangement of PIEZO1 enables fine mechanosensitivities and unique curvature-based gating in lipid membranes ( click to read).

【115】 On April 6, 2022, the David A. Leigh team of East China Normal University/University of Manchester published a research paper titled "Autonomous fuelled directional rotation about a covalent single bond" online in Nature . This study demonstrated 1-phenylpyro2,2' - Dicarboxylic acid (1a) is a catalytically driven motor that continuously induces repeated 360° directional rotations of two aromatic rings from chemical fuel around the covalent N-C bond connecting them. In short, this study designed a unidirectional rotational molecular motor with traditional energy-driven mode motion through reasonable structure and regulation mechanism, and achieved unidirectional controllable spontaneous rotation controlled by chiral fuel and catalyst.

【116】 On April 6, 2022, Zhu Weihong and Andrew I. Cooper of East China University of Science and Technology jointly published an online publication titled "Reconstructed covalent organic" in Nature frameworks" research paper, which reports a general and scalable method for the preparation of robust, highly crystalline imine COFs based on framework reconstruction. In contrast to standard methods in which monomers are initially randomly arranged, the study's method involves pre-organization of monomers using reversible and removable covalent tethers, followed by restricted polymerization. This reconstruction route produces reconstructed COFs with greatly improved crystallinity and higher porosity through a simple vacuum-free synthesis procedure. The increased crystallinity in the reconstituted COF improves charge carrier transport, leading to photocatalytic hydrogen evolution rates as high as 27.98 mmol h−1 g−1. This nanoconfinement-assisted reconstruction strategy is a step toward programming capabilities in organic materials through atomic structure control ( click to read).

【117】On March 30, 2022, Evgeny Nudler of New York University and Zhang Yu of the Institute of Plant Physiology and Ecology of the Chinese Academy of Sciences published an online publication titled "Crucial role and mechanism of transcription-coupled DNA repair in Nature bacteria" research paper, which combines cellulose cross-linking mass spectrometry with structural, biochemical and genetic methods to map transcription-coupled DNA repair, TCR) complex (TCRC) and determine the actual sequence of events leading to NER in vivo. The study identified RNA polymerase (RNAP) as the primary sensor of DNA damage and as a platform for NER enzyme recruitment. UvrA and UvrD continuously bind to RNAP to form pre-TCRC surveillance. In response to DNA damage, pre-TCRC recruits a second UvrD monomer to form a helicase-competent UvrD dimer, promoting TCRC backtracking. Attenuation of UvrD-RNAP interaction sensitizes cells to genotoxic stress. The TCRC then recruits a second UvrA molecule and UvrB to initiate the repair process. Contrary to conventional wisdom, the study found that TCRs accounted for the vast majority of chromosome repair events; that is, TCRs completely dominated global genome repair. The study also shows that TCR is largely independent of Mfd.

【118】 On March 30, 2022, Cheng Xiang of the University of Minnesota and Xu Xinliang of Beijing Normal University/Beijing Computational Science Center jointly published an online publication in Nature entitled "The colloidal nature of complex fluids enhances bacterial motility” research paper, which shows that flagellar bacteria in dilute colloidal suspensions of exhibit quantitatively similar motility behaviors to those in dilute polymer solutions , specifically a generalized particle size-dependent motility enhancement of up to 80%, coupled with a strong inhibition of bacterial oscillation. The research results contribute to the understanding of bacterial motility behavior in complex fluids, which is related to a wide range of microbial processes and engineering bacterial swimming in complex environments ( click to read).

[119] March 30, 2022, B. Andrei Bernevig, Nicolas Regnault of Princeton University and Xu Yuanfeng of the Max Planck Institute for Microstructural Physics in Germany jointly communicated ( Nicolas Regnault of Princeton University, Song Zhida, Xu Yuanfeng of the Max Planck Institute of Microstructural Physics in Germany, Li Mingrui of the Department of Physics of Tsinghua University, Dashuai Ma of the School of Physics of Beijing Institute of Technology and Luis University of the Basque Country Elcoro is the co-first author of ) published online in Nature titled "Catalogue of flat-band stoichiometric materials" research paper, this research provides for the first time a standard for judging the flatness of energy bands in a system and uses this standard to conduct high-throughput research on the electronic properties and topological properties of 55,206 systems in the inorganic crystal structure database. The article gives 6338 ICSDs (corresponding to 2379 materials) with flat band characteristics. With the original intention of seeking material carriers with experimental synthesis potential, the article further selected 345 candidate systems. This study proposes the S matrix method for the first time, systematically reveals the origin of topologically nontrivial flat bands in the above five special lattices, and conducts a detailed analysis of the flat band system with five special lattices through first-principles calculations and effective model methods.

【120】 On March 28, 2022, David S. Eisenberg’s team at the University of California, Los Angeles (Cao Xiao from Shanghai Jiao Tong University and others are the first authors) published online in Nature titled "Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43” research paper, which extracted amyloid fibrils from the brains of four patients, representing four of the five FTLD-TDP subclasses, and examined them by cryo-electron microscopy (cryo-EM) Their structures were determined at near-atomic resolution. Unexpectedly, all amyloid fibrils examined were composed of the 135-residue C-terminal fragment of transmembrane protein 106B (TMEM106B) , a lysosomal membrane protein previously implicated as a genetic risk factor for FTLD-TDP. As revealed by immunogold labeling, in addition to TMEM106B fibrils, there is also the presence of large amounts of nonfibrillar aggregated TDP-43. Taken together, the study's observations confirm that FTLD-TDP is an amyloid-related disease and suggest that amyloid in FTLD-TDP is associated with the protein TMEM106B, rather than TDP-43 (click to read).

【121】 On March 23, 2022, Zhenan Bao’s team from Stanford University (Wang Yixuan from Tianjin University is the co-first author) published an online article titled "High-brightness all-polymer stretchable LED with charge-trapping" in Nature dilution" research paper, which reports a material design strategy and fabrication process to achieve stretchable all-polymer light-emitting diodes with high brightness (approximately 7,450 candelas per square meter), high current efficiency (approximately 5.3 candelas per amp), and high stretchability (approx. 100% strain). This research fabricated red, green and blue stretchable all-polymer light-emitting diodes to achieve wireless power supply and real-time display of pulse signals on the skin. This work marks a significant advancement in high-performance stretchable displays ( click to read).

【122】 On March 23, 2022, Lai Ying of Sichuan University, Axel T. Brunger of Stanford University, Burton F. Dickey of the University of Texas MD Anderson Cancer Center and Manfred Frick of the University of Ulm, Germany jointly published an online publication titled "Inhibition of calcium-triggered secretion by hydrocarbon-stapled" in Nature peptides" research paper, the researchers designed a hydrocarbon-fixed peptide to specifically disrupt Ca2+-triggered membrane fusion by interfering with the so-called primary interface between the neuronal SNARE complex and the Ca2+-binding C2B domain of synaptotagmin-1.Conjugating the cell-penetrating peptide to an immobilized peptide was efficiently delivered into cultured human airway epithelial cells and mouse airway epithelial cells, where it significantly and specifically reduced stimulated mucin secretion in both systems and greatly alleviated mucus obstruction of the mouse airways. Taken together, peptides that disrupt Ca2+-triggered membrane fusion may enable therapeutic modulation of the mucin secretion pathway.

【123】 On March 21, 2022, in cooperation with multiple units including the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, BGI, Jilin University, Miguel A. Esteban, Liu Longqi, Li Wenjuan and Md. Abdul Mazid jointly published a paper titled "Rolling back human pluripotent stem cells" in Nature to an eight-cell embryo-like stage" research paper, which describes a transgene-free, rapid and controllable method to generate 8C-like cells (8CLCs) from human pluripotent stem cells. Single-cell analysis identified key molecular events and gene networks associated with this transformation. Loss-of-function experiments identify essential roles for DPPA3, a master regulator of DNA methylation in oocytes, and TPRX1, a eutherian totipotent cell isoform box (ETCHbox) family transcription factor that is absent in mice. DPPA3 induces DNA demethylation throughout 8CLC transformation, and TPRX1 is a key executive of the 8CLC gene network. This study further demonstrates that 8CLCs can generate embryonic and extraembryonic lineages in the form of blastocysts and complex teratomas in vitro or in vivo. The study's methods provide a resource for unraveling the molecular processes of early human embryogenesis.

【124】On March 16, 2022, Lu Cewu of Shanghai Jiao Tong University and Kay M. Tye of Howard Hughes Medical Institute in the United States jointly published an online publication titled "Cortical ensembles orchestrate social competition through hypothalamic" in Nature outputs” research paper, which developed a social competition experiment in which mice compete for rewards, and a computer vision tool (AlphaTracker) to track multiple unlabeled animals. Hidden Markov models combined with generalized linear models are able to decode social competition behavior from mPFC integrated activity. Population dynamics in the mPFC predict social rank and competitive success. Finally, this study demonstrates that mPFC cells projecting to the lateral hypothalamus promote dominant behavior during reward competition. Thus, this study reveals a cortico-hypothalamic circuit through which the mPFC exerts top-down regulation of social dominance.

【125】 On March 15, 2022, Yang Yang of the University of California, Los Angeles, Wang Rui of West Lake University and Jin-Wook Lee of Sungkyunkwan University in South Korea jointly published an online publication titled "Stability-limiting heterointerfaces of perovskite" in Nature photovoltaics” research paper, which shows that surface treatment may induce a negative work function shift (i.e. more n-type), which activates halide migration to exacerbate PSC instability. Thus, despite the beneficial effects of surface passivation, this deleterious side effect limits the maximum stability improvements that can be obtained for PSCs treated in these ways. This trade-off between beneficial and adverse effects should guide further work on improving PSC stability through surface treatments ( click to read).

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