引言
作為細胞進行有氧呼吸和能量生產的主要場所，線粒體（mitochondria）是一種幾乎存在於所有真核細胞中的細胞器，被稱作細胞的「動力工廠」。近年來研究發現除了為細胞基本生命活動提供能量，線粒體還在細胞信號轉導、代謝產物合成、基因轉錄調控和細胞凋亡等過程中扮演重要角色【1,2】。以上線粒體功能的研究主要在單細胞真核生物（例如酵母）或體外培養細胞系中完成，對於其在高等生物體內細胞增殖、分化和命運決定過程中的功能性研究還十分有限。此外，在多細胞構成的組織與器官水平下，線粒體損傷導致的細胞脅迫對於不同類型細胞生命活動的影響是否具有偏好性仍是一個有待解決的問題。
2024年8月23日，加州大學聖地亞哥分校孫欣實驗室在cell stem cell雜誌在線發表了題為「context-dependent roles of mitochondrial lonp1 in orchestrating the balance between airway progenitor versus progeny cells」的研究論文。該研究揭示了線粒體在呼吸道上皮組織發育、穩態維持以及損傷修復中的功能，並且發現線粒體在同一組織中以細胞特異性的方式調控細胞增殖分化、凋亡或者長距離遷移。
參考文獻
1. monzel, a.s., enriquez, j.a., and picard, m. (2023). multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction. nat metab 5, 546-562. 10.1038/s42255-023-00783-1.
2. mcbride, h.m., neuspiel, m., and wasiak, s. (2006). mitochondria: more than just a powerhouse. current biology 16, r551-r560. 10.1016/j.cub.2006.06.054.
3. ray, s., chiba, n., yao, c., guan, x., mcconnell, a.m., brockway, b., que, l., mcqualter, j.l., and stripp, b.r. (2016). rare sox2(+) airway progenitor cells generate krt5(+) cells that repopulate damaged alveolar parenchyma following influenza virus infection. stem cell reports 7, 817-825. 10.1016/j.stemcr.2016.09.010.
4. vaughan, a.e., brumwell, a.n., xi, y., gotts, j.e., brownfield, d.g., treutlein, b., tan, k., tan, v., liu, f.c., looney, m.r., et al. (2015). lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. nature 517, 621-625. 10.1038/nature14112.
5. kumar, p.a., hu, y., yamamoto, y., hoe, n.b., wei, t.s., mu, d., sun, y., joo, l.s., dagher, r., zielonka, e.m., et al. (2011). distal airway stem cells yield alveoli in vitro and during lung regeneration following h1n1 influenza infection. cell 147, 525-538. 10.1016/j.cell.2011.10.001.
6. chen, s., kuhn, m., prettner, k., yu, f., yang, t., barnighausen, t., bloom, d.e., and wang, c. (2023). the global economic burden of chronic obstructive pulmonary disease for 204 countries and territories in 2020-50: a health-augmented macroeconomic modelling study. lancet glob health 11, e1183-e1193. 10.1016/s2214-109x(23)00217-6.
7. aghapour, m., remels, a.h.v., pouwels, s.d., bruder, d., hiemstra, p.s., cloonan, s.m., and heijink, i.h. (2020). mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease. am j physiol-lung c 318, l149-l164. 10.1152/ajplung.00329.2019.
8. gibellini, l., de gaetano, a., mandrioli, m., van tongeren, e., bortolotti, c.a., cossarizza, a., and pinti, m. (2020). the biology of lonp1: more than a mitochondrial protease. int rev cel mol bio 354, 1-61. 10.1016/bs.ircmb.2020.02.005.
9. carpio, m.a., means, r.e., brill, a.l., sainz, a., ehrlich, b.e., and katz, s.g. (2021). bok controls apoptosis by ca(2+) transfer through er-mitochondrial contact sites. cell rep 34, 108827. 10.1016/j.celrep.2021.108827.
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