Bispecific antibodies have become a hot spot in the field of antibody engineering and have broad application prospects in tumor immunotherapy. It can recombinate antibodies with different mechanisms of action, and under certain conditions, it can also add new combination effects

Category：science

2025-08-28

bispecific antibody has become a hot spot in the field of antibody engineering and has broad application prospects in immunotherapy for tumors. It can recombinate antibodies with different mechanisms of action, and under certain conditions, it can also add new combination effects and overcome the side effects of combined use of traditional monoclonal antibodies. Although the complex and non-natural structures lead to some unique technical challenges in process development and production amplification of each molecular configuration, there are actually some commonalities behind these difficulties and the theoretical basis for solving problems is also similar. The higher technical requirements and more challenges of bianti-anti-drug development require the development of corresponding strategies for molecular characteristics at each stage of CMC development to reduce development risks.

1 November 27 at 14:30 pm , industry colleagues gathered in the "Freework Live Broadcast Room" to give special explanations on the strategies and key points in the research and development of antibody drugs, especially bispecific antibody drugs, challenges and responses in the characterization of chromatography of antibody protein drugs, and protein purification processes, to accelerate the development of dual-anti-drugs.

This live sharing, Dr. Zhu Yixiang, Deputy General Manager of Kangri Baiao, will introduce the key points and development strategies from different stages of dual-antibody process research, and combine some actual cases in the development process of dual-antibody to explain how to ultimately achieve the production of products that meet quality requirements while the production scale is continuously stable.

Kanribaio has delivered multiple bispecific antibody cell line construction and preclinical pharmacy research projects. It has rich experience in the process development and production of biantibodies, which can help partners shorten the development cycle and promote molecules to rapidly advance clinical practice with robust processes and efficient production.

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