Jimu News reporter Li Wanrong
Correspondent Ji Xianxian Yang Ya
Clear face, petite stature, sweet smile... Post-95 doctor Gao Min from the Digital PET Laboratory of Huazhong University of Science and Technology seems to have a different understanding of doctors than ordinary people. In the same way, she loves scientific research and is also a lover of Chinese culture. Her sweet smile is her trademark, but when it comes to scientific research, she is extraordinarily serious and rigorous. Recently, the international authoritative journal "IEEE Transactions on Radiation and Plasma Medical Sciences" ("IEEE Transactions on Radiation and Plasma Medical Sciences") published online the latest research results of Chinese scientist Xie Qingguo's team. The first experimental results of online in-beam monitoring of the proton knife in live animals.
Post-95 Doctor Gao Min from the Digital PET Laboratory of Huazhong University of Science and Technology
Promise to advance the research on precision proton knife therapy Dual Heads for In-beam Beam-on Proton Therapy Monitoring.
For the first time, this study used a living animal as an experimental object, and used digital PET to monitor the actual range of action and delivery dose of the proton beam entering its body, and obtained the world's first experimental result of online in-beam monitoring of the proton knife on a living animal. . The researchers believe that this may be a small step in the history of precise treatment with proton knife, which is a "powerful tool for cancer treatment".
Gao Min introduced that since the 1990s, scientists around the world have been working hard to explore the feasibility of using PET for proton monitoring, but the positron nuclides generated by proton beams have an extremely short half-life and a large number of background scattered gamma photons. Quantitatively estimating the delivered dose and range of proton beams in human tissues is a huge unsolved challenge.
Animal live proton knife online monitoring experiment
"As far as I know, we should be the first research team in the world to obtain the results of live proton therapy in-beam monitoring." Gao Min introduced that the digital PET system with ultra-high count rate can support In the true sense of the on-beam signal acquisition, the on-beam signal processing algorithm based on the plug-and-imaging architecture can suppress the complex radiation background noise, thereby providing proton beam-induced positron activity images with high signal-to-noise ratio.
Gao Min introduced that this work shows that digital PET can provide unprecedented new data for the study of the interaction mechanism between proton beams and biological tissues, and is expected to spawn a series of new theories, new algorithms, and new technologies for proton therapy. New phenomena may also be discovered in the observations of secondary particles.
Doing scientific research with the enthusiasm of "hot-headed"
In 2017, Gao Min graduated from undergraduate and joined the digital PET team as a direct doctoral student, and has been engaged in the research of digital PET in online monitoring of proton therapy.
mentioned the student Gao Min, and the tutor Xie Qingguo praised: "She was an undergraduate student and went to the Geneva Invention Exhibition to win a gold medal." With a fair face and petite stature, Gao Min, who was still a senior at the time, looked older than her actual age. Appearing immature.On the first day of the exhibition, a foreign expert at the booth opposite Gao Min took her as a junior high school student, and asked the translator of his peers in confusion: How can there be children coming to the exhibition? The foreign expert was surprised when the translator told the foreign expert that Gao Min was the only person in charge representing the helmet-mounted PET project.
Gao Min won the gold medal at the Geneva Invention Exhibition.
Gao Min has a motto: "We will do nothing while our minds are hot!" This passion and dedication was brought to her scientific research career, and she explained it vividly with practical actions. In October 2017, Gao Min and Nicola, an Italian professor from the Digital PET Laboratory, went to Taipei Chang Gung Hospital to conduct an experiment of all-digital flat-panel PET for proton beam online monitoring. For the first time, the oxygen 15 generated by the proton beam hitting the prosthesis was detected, which opened a new application of digital PET in the direction of proton radiotherapy. Behind the impressive achievements of
is Gao Min's sleepless efforts and persistence. Due to the high cost of proton radiotherapy, the experimental time occupied in the treatment room is also "an inch of time is worth an inch of gold". Gao Min recalled that at that time, after she and Nicholas brought more than 80 kilograms of equipment to Chang Gung Memorial Hospital, they worked day and night, including system construction, equipment debugging, experimental collection, and dismantling and clearing. The whole process only took 96 hours. "Because the beam conditions of the Proton Hospital are very tight, the experiment always starts at about 10 pm after the end of the day's patient diagnosis and treatment, ends at 2 or 3 am the next day, and then starts to prepare for the next round of experiments at 5 or 6 am in the morning.
Gao Min is always enthusiastic about the research work in the field of digital PET. "Although I will endure a lot of hardships and overcome many difficulties on the road of scientific research, the fun of fighting monsters and upgrading can only be experienced here." It took 4 days to build a PET system, and she also found the surprise and fun of building large-scale Lego.She introduced that the traditional PET construction time is calculated in months or even years, while ours is in hours. This allowed her to truly experience the revolutionary changes brought about by the modularity, openness and flexibility of digital PET.
There are more than one student like Gao Min in the digital PET laboratory. Professors Xie Qingguo, Xiao Peng, Nikolai, etc., the tutors of the laboratory, spared no effort to find good seedlings, and then patiently cultivate them, waiting for the fruits to bear fruit. The digital PET laboratory has also produced many innovative talents, not only the leading talents in the high-end medical imaging industry, but also the technology pioneers in the high-end manufacturing industry, the technical experts of the Internet "big factories", and the young scholars in the field of scientific research.
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