Antibacterial and biocompatible material is based on hydroxyapatite, a promising implantable material with a structure similar to the solid tissue of the human body. Scientists in the Department of Chemistry at Lobachevsky University have improved its composition and structure to make it stronger and safer and eliminate possible postoperative complications. Bioceramics can stimulate the repair of bone defect while preventing the development of bacterial infection.
In the classic component of Ca 10 (PO 4 ) 6 (OH) 2 hydroxyapatite, scientists added bismuth (Bi) ions as antibacterial , which minimizes the risk of postoperative infection and reduces the possibility of reoperation. In this case, bismuth is firmly fixed in the lattice of the compound and does not accumulate in the body tissue outside the implant.
In addition, bioceramics have been modified with sodium (Na) ions and fluorine (F) ions to improve biocompatibility , thereby making the material more stable and improving its effectiveness in the dental field. Thus, the researchers obtained fluorapatite Ca 10-2x BixNax(PO 4 ) 6 F 2, which can prove its effectiveness in the production of medical ceramic materials or metal bio material coatings.
"Today, the application of apatite-based materials is not as widespread as small "spare parts". We believe that if strengthened with bismuth, supplemented with multiple biologically sourced elements such as fluorine and sodium, the quality of the prosthesis can be significantly improved. This may be a breakthrough in combating postoperative infection.
We can use only one compound - the crystalline chemical analog of bone, rather than filling the implant with the whole body of antibiotic . Short-term tests we conducted have shown that our materials are not dangerous to human cells," said Evgeny Bulanov, co-author of the study and associate professor of Analytical and Medicinal Chemistry at Robachevsky State University.
Due to the special crystal structure , the bioceramics obtained by Nizhny Novgorod scientists showed low cytotoxicity in vitro, that is, the substance will not attack healthy tissue outside the implant. The round shape of fluorapatite particles helps them easily penetrate cell membrane and effectively affect pathogens. All of this opens up a wide range of possibilities for the application of new materials in medicine.
The results of this study were published in the collection of "Bioceramics: Applications and Research Progress" by Nova Science Publishers. The project was conducted in the chemistry laboratory of UNNN natural compounds and their synthetic analogues within the framework of Novgorod REC.
