Recently, the top international respiratory journal European Respiratory Journal published the latest research results of the Huazhong University of Science and Technology Tian Yaohua's research group of the School of Public Health, Tongji Medical College, entitled "air pollutants, genetic susceptibility and risk of incident idiopathic pulmonary fibrosis" (Air pollutants, genetic susceptibility and risk of incident idiopathic pulmonary fibrosis 4).
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia , and is a chronic, irreversible progressive fibrotic lung disease. This disease lacks effective therapeutic drugs, and the average survival period of patients with IPF after diagnosis is only 2-4 years. In recent years, more and more research evidence suggests that air pollution may be a risk factor for IPF. Experimental studies have reported that air pollution is related to various pathophysiological mechanisms of IPF. In addition, some epidemiological studies have found that air pollution exposure is associated with increased IPF, hospitalization and death. However, no research has been conducted to explore the association between individual air pollution exposure and IPF onset.
This study included 433,738 study subjects from UK Biobank, and 1,380 cases were confirmed after an average follow-up of 11.8 years. After controlling for a variety of confounding factors, found that for every interquartile spacing of NO2, NOX and PM2.5 exposure concentrations increased by 11% (HR: 1.11, 95% CI: 1.03-1.09), 7% (HR: 1.07, 95% CI: 1.01-1.12) and 9% (HR: 1.09, 95% CI: 1.02-1.17).
Dose-response relationship of the risk of idiopathic pulmonary fibrosis
This study further explores the effect modification of genetic susceptibility on atmospheric pollution-IPF. To study risks, the genetic risk score of IPF constructed based on 13 SNP sites is closely related to IPF incidence and has an additive interaction with NO2, NOX and PM2.5. Compared with the low-gene risk and low-air pollution exposure group, the high-gene risk and high-air pollution exposure group had the highest risk of disease [NO2: 3.94 (2.77, 5.60); NOx: 3.08 (2.21, 4.27); PM2.5: 3.65 (2.60, 5.13); PM10: 3.23 (2.32, 4.50)].
combined effect of air pollutant exposure and genetic risk score and the risk of idiopathic pulmonary fibrosis
In summary, this study found that for the first time that long-term exposure to air pollution in individuals increased the risk of IPF. There is an additive interaction between genetic factors and air pollution exposure on the risk of IPF.
Hanzhong University of Science and Technology Tongji Medical College Doctoral student Cui Feipeng and Professor Sun Yu of Union Hospital are co-first authors, and associate researcher Tian Yaohua is the corresponding author of .
Tian Yaohua is an associate researcher and doctoral supervisor at the School of Public Health, Tongji Medical College, Huazhong University of Science and Technology. The main research direction is big data mining, which explores the influencing factors of maternal and infant health based on the birth cohort, as well as explores the health effects and risks of environmental factors such as air pollution and climate change on people. A series of results have been achieved in the research work. Currently, the first author has published many research papers included in SCI in BMJ, PLoS Med, Int J Epidemiol, Epidemiology, Stroke, etc.
Huazhong University of Science and Technology Tongji Medical College School is one of the six earliest health departments established in the country . In the fourth round of the Ministry of Education’s discipline evaluation, it was rated as the A+ discipline of public health and preventive medicine. Both the first and second rounds were selected as the “ Double First-Class ” construction discipline. The college is based on moral education and people-oriented, adheres to the motto of "pursuing excellence and promoting health", actively creates a high-level public health college with "domestic first-class and international leading", and is determined to cultivate leading public health talents with "international vision, family and country feelings, professional excellence, and a final say". Over the past decades, the School of Public Health of Tongji Medical College of Huazhong University of Science and Technology has trained nearly 10,000 talents. Many outstanding alumni have served as leadership positions and business backbones in domestic disease control systems, health systems, universities and institutes, and many outstanding alumni have achieved remarkable achievements abroad.
In the future, I look forward to more achievements engraved with the imprint of " Huazhong University of Science and Technology " coming out from here and making greater contributions to scientific and technological innovation!
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Material source: Huazhong University of Science and Technology News Network, Huazhong University of Science and Technology Tongji Medical College School of Public Health Official Website, Huazhong University of Science and Technology Teachers’ personal homepage
