To this end, researchers such as University of California at Davis Andreas J. Bäumler published a review in Science and concluded that the health status of the intestinal flora can be assessed more from the host's ability to control the intestinal flora and serve as a target for

https://www.science.org/doi/10.1126/science.abp9960

A series of recent studies have shown that intestinal flora are closely related to host health (1–4); it is believed that a healthy and coordinated intestinal flora is beneficial to the host. beneficial, otherwise it may cause disease. But a problem here is how to define healthy and coordinated flora and dysbiosis? After all, the intestinal flora varies greatly between individuals, and the same person will also have normal accompanying changes at different developmental stages (4, 5).

To this end, researchers such as University of California at Davis Andreas J. Bäumler published a review in Science and believed that the health status of the intestinal flora can be assessed more from the host's ability to control the intestinal flora and serve as a target for intervention. . This is because 1. The host's intestines can control the secretion of oxygen and nitrate , etc., and form a concentration gradient; 2. Oxygen and nitrate in the environment can serve as important electron acceptors to affect the distribution of bacterial flora and Metabolic state; 3. This theory can well explain how high-fat and low-fiber diets can lead to dysbiosis and lead to obesity and cardiovascular disease; that is, the digestates of these diets will affect the mitochondrial function of the intestinal epithelium, causing the intestine to control oxygen release. Decreased ability (5).

This work was published in Science on July 1; the researchers envision that in the future, they can further combine other ways of controlling the flora of the host, study the "bacteria health reference value" based on host quantitative indicators, and intervene in the host when necessary. Regulate flora and alleviate diseases related to dysbiosis (5).

Comment(s):

Although the environment provided by the host certainly affects the intestinal flora, the potential impact of the mitochondrial status of intestinal epithelial cells on the intestinal flora is a bit incredible intuitively. I look forward to direct experimental evidence here; if this If the theory holds true, perhaps the colorectum cannot "air in" regularly.

Corresponding author introduction:

https://biology.ucdavis.edu/people/andreas-baumler

References:

1. M. Boehme et al., Microbiota from young mice counteracts selective age-associated behavioral deficits. Nat. Aging. 1, 666–676 (2021).

2. V. Gopalakrishnan, B. A. Helmink, C. N. Spencer, A. Reuben, J. A. Wargo, The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy. Cancer Cell. 33, 570–580 ( 2018).

3. P. Smith et al., Regulation of life span by the gut microbiota in the short-living African turquoise killifish. microbiota - at the intersection of everything? Nat. Rev. Gastroenterol. Hepatol. 14, 321–322 (2017).

5. J.-Y. Lee, R. M. Tsolis, A. J. Bäumler, The microbiome and gut homeostasis. Science (80- . ). 377 (2022), doi:10.1126/SCIENCE.ABP9960.

Original link:

https://www.science.org/doi/10.1126/science.abp9960