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Author: Tiffany
Introduction: With the spread of new coronavirus worldwide, more and more scientists are also beginning to develop effective Drugs for the treatment of Covid-19. Recently, another group of scientists has launched research on new coronary drugs...
In the case of the continuous increase in the number of confirmed cases of new coronary pneumonia (COVID-19) in the United States, it can help patients with respiratory diseases escape serious New drug therapies for diseases are beginning to receive attention.
The World Health Organization recently approved a antibody drug cocktail produced by Regeneron Pharmaceuticals, which is a combination drug that is widely used to support patients by injecting the antibody to fight COVID. People are studying a new antiviral drug molnupiravir that can be taken daily, which can prevent the development of the COVID disease in the early stage.
Several experts in the northeastern United States said that although these COVID treatment methods help support hospital resources by preventing many patients from suffering from serious diseases, they are far from a panacea and face many challenges in terms of production and effectiveness.
"This is the challenge facing respiratory viruses-it is difficult to develop a good antiviral drug," said Northeastern University clinical associate professor of pharmacy and health system science Brandon Dionne . "And there is not much motivation in the market" to pursue these therapies.
COVID treatment is divided into the following categories: antibody therapy,Use laboratory-produced antibodies to help prevent virus replication; antiviral drugs, which specifically target and kill virus particles; and corticosteroid , which can help reduce the body's inflammatory response to infection.
Dionne said that antibody therapy such as Regeneron's antibody therapy, which combines casirivimab and imdevimab into a "monoclonal antibody cocktail", has been shown to be effective in reducing COVID-19 hospitalization, although it must be in the disease Early use of the process. According to data in an article titled "REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19" published in "New England Journal of Medicine" on Wednesday, this drug cocktail has also been shown to help relieve COVID symptoms and reducing the viral load of patients:
Some hospitals in Massachusetts touted this therapy, and claims it helps save lives during the peak summer period. However, due to the continued shortage of supplies, states began to restrict the use to high-risk patients, especially those who have not been vaccinated. In recent months, approximately 70% of the nation’s antibody treatments have been supplied to the hardest-hit states, including Tennessee, Alabama, Mississippi, Florida, Georgia_ span8span, Louisiana and Texas.
In addition,Whether it is monoclonal antibody therapy or the use of antiviral drugs, the timing of treatment is closely related to the result. Mansoor Amiji , a famous pharmaceutical professor of science and chemical engineering at Tohoku University, said people are also worried about whether these treatments are effective against an evolving virus.
Amiji said that, like vaccines, drug therapies "have a certain affinity with the virus strain initially tested."
Amiji added: "This virus is evolving. "Whether it is in terms of vaccines or drugs, it is trying to resist. Therefore, people may worry that neither these antibodies nor these antiviral drugs will be so effective in the long run.
Amiji said that the research and development of new drug therapies is ongoing, but it is only proceeding with the progress of investment. Due to the focus on vaccines, investment has been delayed. Amiji hopes that this situation will begin to change, he pointed out, New treatments may also help reduce or prevent the symptoms of the so-called "prolonged procrastination", which is characterized by prolonged COVID symptoms, which may affect up to one-third of infected people.
He said: "There are no financial incentives. "New research is needed to develop these new antiviral drugs.
The US Food and Drug Administration said that the only antiviral drug approved for the treatment of COVID, and the only fully approved treatment drug, is Remdesivir. Studies have shown that if the drug is used early, high-risk patients The length of hospital stay can be reduced by up to 87%. However, according to the World Health Organization, there is no evidence that remdesivir reduces the mortality rate of COVID.
remdesivir is not a new drug. Amiji said,This therapy was originally used to treat hepatitis C , and it has been shelved for many years before it was re-used to fight COVID. The drug is not intended to be widely used, and can only be injected intravenously, which further limits the population that can be used.
monoclonal antibody therapy can also be injected intravenously. Experts say that in the later stages of disease progression, these two forms of treatment seem to have little effect on patients.
At that time, various steroid drugs were used, and Dionne said that it was indeed good for reducing mortality.
The prospect of molnupiravir in tablet form is a promising development because it can be used in environments outside the hospital, increasing the treatment options for many people. But Dionne said that so far, compared with the overwhelming efficacy of vaccines, all drug therapies have proven to be "moderately effective."
"They did work," Dionne said, "but so far, vaccines are the most important thing."
Reference:
https://medicalxpress.com/news/2021-10-covid -drug-therapies-horizon.html
Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment options. If you need health guidance, please go to a regular hospital for treatment.
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