Considering that changes in burns depend on the circumstances that caused the burns, the need for personalized medicine and care for burn patients is essential to ensure that the best treatment is provided. With the accuracy and customization level of 3D printing technology, it may be used to make wound dressings and provide better treatment for burn patients. The premise is that the selected material has good printability and can be used to promote wound healing. At the same time, customized rehabilitation is carried out.
Figure 1 A) Schematic diagram of the hydrogel wound dressing used in this study. The wound dressing consists of a 3D printed poly(caprolactone) wafer that serves as the backing layer of the wound dressing and the substrate for printing chitosan methacrylate. B) 3D printed digital image of chitosan methacrylate wound dressing. C) FESEM images of 3D printed chitosan methacrylate made with 4% (w/v) chitosan methacrylate, taken at different magnifications. D) The rheology of chitosan methacrylate at different concentrations. E) Degradation behavior of 4% (w/v) chitosan methacrylate.
Recently, National University of Singapore team studied the versatility of chitosan methacrylate as the material for making customizable wounds through 3D printing dressing. The synthetic chitosan methacrylate was evaluated as printable, biodegradable and biocompatible during wound healing. and load various medicines related to burn treatment,And through 3D printing to produce different multi-material wound dressing designs containing different doses. The incorporation of the drug has no significant effect on the printability of chitosan methacrylate, and the incorporation of antibacterial agent significantly improves its antibacterial ability. Through the in vivo model, these changes in wound dressing design have good wound healing properties and will not cause any adverse effects in the process.
Fig. 5 It is biocompatible with cells in the wound site. B) The percentage of cell viability of NIH/3T3 cells exposed to chitosan methacrylate wound dressings within 3 days as assessed by MTS analysis. C) Visualization of live cells (green) and dead cells (red) of the NIH/3T3 cell layer exposed to chitosan methacrylate wound dressing for 3 days, using calcein-AM and ethidium homodimer-1, respectively dyeing. D) Use the disc diffusion test to evaluate the antibacterial properties of chitosan methacrylate wound dressings of different designs, as well as only the PCL backing layer, the positive control (3M Tegaderm) and the anti- Staphylococcus aureus and patina Negative control of spp. . E) Comparison of the zones of inhibition of Staphylococcus aureus in each group based on their respective diameters. F) Comparison of each group of inhibition zones of Pseudomonas aeruginosa based on their respective diameters.
related thesis entitled 3D Printing Personalized, Photocrosslinkable Hydrogel Wound Dressings for the Treatment of Thermal Burns published in " Advanced Functional Materials "on. Corresponding author Yes National University of Singapore Professor Chi-Hwa Wang .
References:
doi.org/10.1002/adf_span3202.
