Should aspirin enteric-coated tablets be taken after a meal or on an empty stomach? Eat it in the morning or at night?

Aspirin, a century-old drug of

, has the effect of inhibiting platelet aggregation, thereby improving blood circulation and preventing clogging of blood vessels. In recent years, its clinical application has changed from anti-inflammatory and anti-rheumatic in the early years to preventing embolic diseases. , And has become a mainstay in the prevention and treatment of cardiovascular diseases, such as being the first choice recommended for primary and secondary prevention of coronary heart disease. Because of this, many patients need to take aspirin for a long time. Is

aspirin enteric-coated tablets eaten after a meal or on an empty stomach?

We all know that according to its effectiveness and stimulating effect on the gastrointestinal tract, medicine can be divided into pre-meal, post-meal, or before going to bed. The previous ordinary aspirin tablets are suitable to be taken after meals due to their stimulating and damaging effects on the gastrointestinal mucosa. However, with the development of pharmaceutical preparation technology, in order to reduce the direct stimulation of the drug on the gastrointestinal mucosa, aspirin has now been made into enteric-coated tablets for use.

From the characteristics of enteric-coated preparations, aspirin enteric-coated tablets hardly disintegrate in the acidic environment of the stomach, and will only disintegrate and absorb after entering the intestine. Therefore, the time and dose of aspirin enteric-coated tablets determine the onset of action. The speed and the strength of the effect. And if it is still eaten after a meal, the presence of food will undoubtedly slow down the time for aspirin enteric-coated tablets to enter the intestinal tract and delay the onset of effect.

At the same time, food increases the PH value in the stomach, which may cause the drug to disintegrate in the stomach early, reduce the amount of medicine entering the intestine, and affect the efficacy. Therefore, it is recommended to take aspirin enteric-coated tablets on an empty stomach before meals. The medicine is used to prevent and treat cardiovascular diseases in small doses, and it is taken once a day. Therefore, for the convenience of patients, the doctor recommends taking it on an empty stomach in the morning.

The theoretical basis for taking aspirin before going to bed

The statement about taking aspirin before going to bed mainly comes from the belief that the human body has less activity at night, blood flow slows down, and blood viscosity increases, so platelets tend to aggregate. The pharmacokinetics of aspirin tells us that the peak plasma concentration of salicylic acid, its main metabolite after being absorbed, is about 0.3-2 hours after oral administration, but the absorption of aspirin enteric-coated tablets is delayed compared to ordinary tablets. 3-6 hours. Therefore, taking aspirin before going to bed can effectively prevent acute cardiovascular and cerebrovascular accidents in the morning.

Is it better to take aspirin enteric-coated tablets in the morning or before going to bed?

At first glance, it seems more reasonable to take aspirin enteric-coated tablets before going to bed, but in fact this statement ignores the long-term use of patients and the anti-platelet aggregation characteristics of aspirin.

If the drug is taken in a single dose, then according to the pharmacokinetic characteristics of aspirin enteric-coated tablets, it is indeed better to take aspirin before going to bed, but cardiovascular patients need to take aspirin for a long time to maintain a relatively constant blood concentration in the body. Moreover, the anti-platelet aggregation effect produced by aspirin is irreversible, and long-term use will produce a continuous anti-platelet effect throughout the life cycle of platelets, and the regeneration of platelets takes about a week.

So in fact, taking aspirin before going to bed will not have a better effect, as long as it is taken on an empty stomach, in fact, when you take aspirin enteric-coated tablets.

One last thing to remind is that taking aspirin enteric-coated tablets before going to bed may not guarantee an empty stomach, because some patients go to bed early, the food for dinner may not be completely digested, or some patients ate supper. However, I have not eaten for a few hours after getting up in the morning. At least I can guarantee an empty stomach. Therefore, it is recommended to take aspirin enteric-coated tablets in the morning.

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