"The pharmacies are too dark now. A box of ibuprofen can be sold for more than 40 yuan!" Mr. Li is a teacher. He is 35 years old this year and has always been in good health. Recently, Mr. Li has been busy with work and often stayed up until after 1 a.m. Today, after Mr. Li, who

"The pharmacies are too dark nowadays. A box of ibuprofen can sell for more than 40 yuan!"

Mr. Li is a teacher. He is 35 years old this year and has always been in good health. Recently, Mr. Li has been busy with work and often stayed up until after 1 a.m. Today, after Mr. Li, who had been busy for a day, returned home, he began to experience symptoms of fever, cough, and muscle soreness.

In order to relieve the symptoms of fever and muscle soreness, Mr. Li went to the pharmacy to buy medicine! After arriving at the pharmacy, Mr. Li saw many people queuing up to buy medicine, so he started queuing. When it's Mr. Li's turn, he will ask for a box of ibuprofen. When Mr. Li learned that the 5-yuan box of ibuprofen had increased to more than 40 yuan, he was particularly unacceptable. However, thinking that he felt so uncomfortable, Mr. Li had no choice but to pay.

After returning home, Mr. Li complained to his wife and said the sentence at the beginning of the article. After hearing the husband's complaint, Mr. Li's wife said: Who made us fall into their hands? Mr. Li felt that his wife made sense, so he stopped talking.

At present, many people have been infected with new crown . In order to relieve symptoms and prepare backup medicines, they purchased a lot of antipyretic drugs, which made it difficult to find a commonly used antipyretic drugs on the market. In order to let everyone buy antipyretics, today the doctor will give you a good idea!

1. Our antipyretic drugs include ibuprofen and acetaminophen , and aspirin!

When it comes to antipyretic drugs, most people think of ibuprofen and acetaminophen. In fact, our antipyretic drugs are far more than these two.

In clinical practice, antipyretic drugs mainly refer to nonsteroidal anti-inflammatory drugs. This type of drug can act on a substance called cyclooxidase to exert antipyretic and analgesic effects.

cyclooxidase is the key enzyme that catalyzes the conversion of arachidonic acid into prostaglandins, and the presence of prostaglandins can induce an inflammatory response, which in turn causes discomfort to the human body.

In the human body, cyclooxidase is mainly divided into two types, namely cyclooxidase-1 and cyclooxidase-2. The former is mainly found in blood vessels, stomach, and other parts, and can play a role in anti-platelet aggregation and improving blood flow in the gastric mucosa. The latter can mainly catalyze the conversion of arachidonic acid into prostaglandins, which in turn causes discomfort to the human body.

In other words, in order to protect the human body, an ideal state is to inhibit the activity of cyclooxygenase-2 and not affect the activity of cyclooxygenase-1.

However, in the early stages, the antipyretic and analgesic drugs produced simultaneously inhibited the activities of cyclooxygenase-1 and cyclooxygenase-2. This type of drug is called nonselective cyclooxygenase inhibitors, and common ones include aspirin, ibuprofen, and acetaminophen. Since this type of drug can inhibit the activity of cyclooxygenase-1, it will cause gastrointestinal damage, causing symptoms of nausea, vomiting, abdominal pain, etc.

At the earliest, aspirin was used to relieve fever and analgesic pain. However, it was later found that aspirin can cause serious adverse reactions in children, such as Reich syndrome . This complication is mainly manifested in liver failure and encephalopathy. If it is not treated in time, it may endanger the patient's life. Therefore, aspirin gradually withdrew from the ranks of understanding heat and analgesics. After

, people found that aspirin has the effect of anti-platelet aggregation and improving the prognosis of cardiovascular diseases. Therefore, this drug is widely used to treat cardiovascular and cerebrovascular diseases . For patients with coronary heart disease , myocardial infarction, cerebral infarction , etc., if there are no contraindications, doctors will recommend taking aspirin. Gradually, people forget that aspirin has the effect of reducing fever.

2. Why can we buy affordable aspirin? What should I pay attention to when taking aspirin to reduce fever?

At present, the number of confirmed cardiovascular disease patients in my country has exceeded 300 million. Among these people, at least tens of millions of people are taking aspirin every day.In order to ensure the supply of aspirin, the market is sufficient.

At the same time, most of the antipyretic drugs that most friends stock up now are ibuprofen and acetaminophen. There are not many friends who have not bought antipyretics. Therefore, if you want to buy antipyretics, aspirin can also be used as a temporary alternative.

The aspirin sold on the market is mainly sustained-release tablets. This sustained-release tablet has a slow onset of effect and has a long time of action, which is not suitable for rapid fever reduction. Therefore, when we take aspirin, we can divide aspirin into two and then take 3 tablets of 100mg of aspirin (the minimum effective dose of aspirin to reduce fever is 300mg).

If you experience abdominal pain, black stool, or liver function damage during aspirin, stop taking it as soon as possible. At the same time, taking aspirin to reduce fever, cannot be taken for a long time, the time for use cannot exceed 3 days, and the interval between medication should be at least not less than 4 hours, and the number of times taken within a day should not exceed 4 times. If the fever lasts for more than 3 days and cannot be relieved, you should go to the hospital as soon as possible.

Although aspirin has antipyretic effects, some people cannot take this drug, such as children, patients with gastrointestinal bleeding, people allergic to aspirin, and people at risk of bleeding. When we buy aspirin, we must undergo evaluation by a professional pharmacist or doctor, otherwise there will be certain safety hazards.

3. In addition to drug cooling, we can also take physical cooling methods!

In fact, there are many antipyretic drugs, such as nimesulil , aminopyrine , celecoxib, etc. Here we only provide some ideas for everyone, and you are not allowed to buy it yourself. If you really want to buy it, you must do it under the guidance of a professional!

In addition to drug cooling, it also has physical cooling. At present, the most commonly used thing for physical cooling is anti-heating patches, but this method has been disclosed by some people to be an IQ tax.

In fact, there is also a free physical cooling that everyone gradually forgets, that is, wiping the bath with warm water. When performing a warm water wiping bath, the air conditioner should be turned on to ensure that it is carried out at a suitable temperature. It is very important to wipe the bath in warm water. Common ones mainly include the neck, trunk, armpits, elbows, groin , leg cubits, etc. These parts have rich blood vessels, so they dissipate heat faster. If you scrub other locations, the anti-heat effect is not good. When wiping the bath, pay attention to the above mentioned parts and rub them back and forth at least twice.

You can drink more boiled water during the fever. This is because drinking too much boiled water will make you urine more, and urine can take away some of the calories.

Many people may choose alcohol scrubbing, so I won't recommend it here. This is because alcohol is quite irritating and is not very suitable for those children with broken skin or children.