Pharmacological effects: 1. Drugs that interfere with nucleic acid biosynthesis are gradually converted into 5-fluorouracil in the body. The metabolite of 5-fluorouracil competitively binds to thymine nucleotide synthase and inhibits DNA synthesis.

2025/10/2415:54:36 regimen 1970

1. Indications:

Unresectable locally advanced or metastatic gastric cancer .

2. Pharmacological effects:

① Drugs (antimetabolites) that interfere with nucleic acid biosynthesis are gradually converted into 5-fluorouracil in the body. The 5-fluorouracil metabolite competitively binds to thymine nucleotide synthase, and inhibits DNA synthesis. It can also disrupt RNA function. Play an anti-tumor role.

② Gimepyrimidine can inhibit the 5-fluorouracil catabolic enzyme , increases the concentration of 5-fluorouracil and enhances the efficacy of tegafur.

③ Otiracil potassium can inhibit orotate phosphoribosyltransferase, inhibit the conversion of 5-fluorouracil into 5-fluoronucleotide, and can reduce gastrointestinal adverse reactions .

3. Ingredients:

tegafur, gimetrazine, oteracil potassium .

4. Adverse reactions:

① bone marrow suppression : leukopenia, thrombocytopenia , etc.

② Liver: elevated transaminases, etc.

③Gastrointestinal reactions: loss of appetite, nausea and vomiting, diarrhea, stomatitis, abnormal taste , etc.

④Skin: Pigmentation.

⑤Allergic reaction: rash , itching, etc.

⑥ Others: general malaise, headache, dizziness, epiphora, conjunctivitis , etc. wait.

5. Note:

is prohibited or used with caution in the following situations: pregnancy, lactation, bone marrow suppression, abnormal liver and kidney function, infectious diseases, heart disease patients, patients with peptic tract ulcers , etc.

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Note: prescription drugs must be prepared, purchased and used with the prescription of a licensed physician or a licensed assistant physician.

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