sildenafil is well-known to everyone for the treatment of male ED. It is a selective inhibitor in medicine and is an oral drug for the treatment of ED.
At the beginning, sildenafil was mainly used to cooperate with the study of 5-phosphodiesterase inhibitors for the treatment of cardiovascular diseases. Later, it was found that sildenafil had a good effect on improving male ED. It was approved by Viagra for the FDA and created a myth of sales of millions in just a few weeks.
sildenafil increases cyclic guanosine phosphate in tissues by inhibiting the activity of phosphodiesterase , relaxes the smooth muscles of Y-stem cavernosum and arterioles in Y-stem, increases local blood flow in the tissue, and achieves the purpose of treating male ED. What is the maximum dose of sildenafil available?
When used to treat male ED, the dose is 25~100mg, and the most commonly used dose is 50mg. If there are side effects, the dose should be reduced to 25mg. If the drug is well tolerated but the effect is not particularly satisfactory, the dose can be increased to 100mg.
However, the maximum dose of the drug cannot exceed 100 mg. You can take the drug at most once a day. If the individual is weak, the dosage needs to be reduced, which can be reduced to about 25 mg each time. It is not recommended to take the drug by yourself. It is recommended to go to the hospital for consultation and follow the doctor's advice to achieve good treatment results.
For severe functional impairment (creatinine clearance <30m/min),>
For liver function impairment (such as cirrhosis ), the recommended starting dose is 25 mg.
htmlThe recommended starting dose for elderly people aged 165 and over 65 years old is 25 mg.
If hearing loss occurs within 24 hours after taking the medication, once this condition is discovered, the use should be stopped immediately and seek medical treatment as soon as possible.
sildenafil in advance how much is the best effect?
sildenafil is a first-line drug for the treatment of male ED. It is a selective 5-type phosphodiesterase inhibitor and can only work during stimulation. The best time for taking
is 30 minutes to 1 hour before the event, and the peak drug concentration reaches about 1 hour after sildenafil enters the body. At this time, with appropriate stimulation, the effect of improving the patient's ED can be achieved.
sildenafil needs to be taken on an empty stomach to promote faster absorption. If the patient is full or takes sildenafil after drinking, the waiting time needs to be extended, which can be performed after 1-2 hours to achieve satisfactory results.
Because sildenafil citrate tablets are orally absorbed, they usually take effect in 10-40 minutes, and the absolute bioavailability is about 40%. Usually, after taking orally for 30-120 minutes on an empty stomach, or after taking orally for 90-180 minutes after a meal, the peak of blood drug concentration can occur, and the obvious Y-stem B-start state can occur.
so it needs to be taken orally 30 minutes to 1 hour in advance according to the different taken before and after meals. The effect is better, which can make cavernosal obviously congested and swelled, increasing hardness and time. The efficacy of denafil lasts about 3-4 hours, and then it loses its effect.
What are the precautions for taking sildenafil?
——Take
On the market, the specifications of sildenafil are 25mg, 50mg and 100mg respectively. The larger the specifications of the drug, the higher the price, the stronger the efficacy, and the greater the risk of adverse reactions.
Therefore, it is best for patients to communicate with the doctor to adjust the dose according to the severity of their ED, the treatment effect after taking the medicine, and the degree of B after taking it.
—disabled people
(1) Sildenafil will dilate blood vessels. It is prohibited for patients with severe coronary heart disease , hypotension , severe heart failure , etc. Otherwise, it will aggravate heart failure , induce angina pectoris, arrhythmia , myocardial infarction, etc.
(2) Sildenafil will have visual color changes, increase the eye's sensitivity to light, or cause blurred vision, so it is prohibited by driving to avoid causing traffic accidents.
(3) Sildenafil is suitable for male ED, which is prohibited for women and children, except for those diagnosed with pulmonary hypertension .
—Don't take
When taking sildenafil, it is not recommended to use α receptor blockers such as tamsolosine hydrochloride sustained-release capsules, terazosin hydrochloride tablets, or nitrate drugs such as nitroglycerin tablets, isosorbate mononitrate sustained-release tablets, to avoid causing a rapid drop in blood pressure and pose a threat to life.
In addition, alcohol will reduce the efficacy of sildenafil, so it is not recommended to take it after drinking.
—Take
If the patient takes it for a long time, it may cause great harm to the body, easily cause dependence, and sometimes it may also cause headaches, cardiovascular diseases, etc.
Therefore, it is recommended that patients do not take it for a long time. It is okay to use it appropriately. You must take the medicine as prescribed by the doctor.
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