proteinuria is an external indicator that reflects glomerular permeability and damage to tubular function. In clinical practice, acute and chronic nephritis, nephrosis syndrome, diabetic nephrosis , lupus nephritis and interstitial nephritis often cause proteinuria. In fact, many tumors can also cause kidney damage, and the clinical manifestations are mainly proteinuria, that is, tumor-related nephropathy. Most of this type of kidney disease occurs after or at the same time as the tumor, and can also occur before the tumor is diagnosed.
Why does tumor damage the kidneys?
1. Tumors can directly invade the tissues of the kidneys, causing kidney damage and causing a series of clinical symptoms, including proteinuria, hematuria, , and renal insufficiency.
2. Due to tumors, the body's immune mechanism disorders occur, and immune damage causes kidney damage, which is the most common tumor-related nephropathy.
What are the common tumors caused by kidney damage?
1, urogenital system tumors
urogenital system tumors include renal cancer , renal pelvis tumors, bladder and testicular tumors , etc. Necrotic substances that invade the kidneys or their own necrotic substances can lead to proteinuria, but this type of tumor generally has abnormalities in hematuria, low back pain and urination. The incidence of renal injury in patients with
2 and other solid tumors
tumors is about 7% to 34%. Various malignant solid tumors can cause renal damage, but lung cancer, gastric cancer , breast cancer , and colon cancer are the most common. Most of these patients have a large number of proteinuria and/or nephrotic syndrome (massive proteinuria, edema, hyperlipidemia, hypoproteinemia), and have microscopic hematuria and mild renal hypofunction. Severe renal failure is rare, and the renal penetration pathology is mostly membranous nephropathy .
3, multiple myeloma
Multiple myeloma often has urine protein qualitative (weaker) and quantitative (larger). This is because "regular" dry chemistry qualitative detection is only sensitive to albumin and is insensitive to spillover proteinuria or light chain urine caused by it. There is no abnormality in the glomerular filtration membrane in this type of patients, but many small molecule proteins are produced in the plasma, which are easily filtered from the glomerular, exceeding the renal tubular reabsorption limit, resulting in proteinuria.
4 and Leukemia
0 Among the kidney damage caused by leukemia, about 50% of the patients have kidney disease and leukemia symptoms at the same time, and a few patients even see the doctor with kidney disease as the first manifestation. Leukemia kidney damage patients have diverse clinical manifestations. Some patients have microscopic or hematuria , some patients have nephrotic syndrome, some patients have polyuria, and even a very small number of patients may experience both kidney enlargement and renal failure.
5, lymphoma,
0 Lymphoma, also have various renal damage symptoms, and their clinical manifestations include: kidney area tumors, hematuria, hypertension, edema, renal insufficiency, etc. nephritis syndrome ; moderate or large amounts of proteinuria; acute renal failure, etc.
In summary, tumors may be manifested as kidney damage. Therefore, for patients with proteinuria, they cannot simply consider kidney disease, especially middle-aged and elderly people. They should go to the hospital for a systematic and comprehensive examination in a timely manner, pay attention to tumor-related screening, early detection, early diagnosis, and early treatment.
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