Uncle Zhang suffered an acute myocardial infarction a month ago. Fortunately, he was sent to the hospital in time. After the emergency department cleared the thrombus in time, Uncle Wang rescued it. However, due to the damage to the heart function, he often panted and felt tight and panted severely after taking two steps. Combined with his previous history of hypertension, the doctor prescribed him captopril and wished him a long-term oral treatment. After taking
for a few days, Mr. Zhang had a dry cough for no reason and began to think it was a lung problem. As a result, he went to the hospital for examination. The doctor judged that it might be caused by the side effects of captopril, so he re-presented a new drug for Mr. Zhang, sakubalivalsartan.
Uncle Zhang asked the doctor that this medicine is relatively unfamiliar. The doctor explained that this is currently the first-line drug for the treatment of chronic heart failure, especially for patients who cannot tolerate ACEI drugs. It can significantly improve heart function. He asked Uncle Zhang to take it for a long time and have regular check-ups. After Mr. Zhang took it regularly as directed by the doctor, the symptoms of palpitations and chest tightness were much better.
1
First understand what is sakubalivalsartan?
The general name of nuctin is sacubitril Valsartan sodium tablets. In clinical practice, it is mainly used to prevent the progression of heart failure, but it is not currently used as a mainstream drug. It is recommended that patients take sartan or priligy drugs or priligy drugs to prevent the progression of heart failure. If the effect is not good, sacubitril Valsartan can be initiated for alternative treatment. However, if you are taking perindopriligy or fosinpriligy drugs at the time of replacement, you must stop taking sacubitril Valsartan for 36 hours.
sakubalivalsartan sodium tablets can reduce the chance of cardiovascular death and reduce the relevant symptoms of heart failure. They can be used in adult chronic heart failure patients with NYHA grades II-IV and LVEF ≤40%. Adverse reactions such as hypotension, hyperkalemia, angioedema, and renal function damage can occur after medication.
Because hyperkalemia may occur, the blood potassium level must be monitored regularly when taking the medication and treated in a timely manner. When combined with ACE inhibitor (ACEI), it will increase the risk of angioedema. Therefore, this drug must be taken after 36 hours of stopping ACEI treatment.
2
Which is better, Priligy or Sartan antihypertensive drugs?
pril antihypertensive drugs such as captopil, benapril, sartan antihypertensive drugs, such as valsartan, losartan, etc., can all be used to lower blood pressure. The antihypertensive effects of the two types of antihypertensive drugs are clear and have almost no adverse effects on glycolipid metabolism, especially patients with chronic heart failure combined with hypertension, cardiac insufficiency, diabetic nephropathy, proteinuria or microalbuminuria after myocardial infarction. The effects of
Priligy antihypertensive drugs and sartan antihypertensive drugs are not much different. They are both antihypertensive drugs with good effect, but the mechanism of action, effect, side effects and prices of the two types of drugs need to be selected under the guidance of a doctor to avoid taking the medicine by yourself.
Mechanism of action
Priligy antihypertensive drugs are angiotensin converting enzyme inhibitors, sartan antihypertensive drugs belong to angiotensin and II receptor blockers (ARB). The two are angiotensin inhibitors, so the mechanisms of action of the two are similar, but because the targets of the two are different, the mechanisms of action of the two are different. Drugs in
ACEI mainly play a role in lowering blood pressure by reducing angiotensin II (Ang II), while ARB drugs mainly play a role in binding with type I receptors by blocking angiotensin receptors.
Effects
pril antihypertensive drugs have better effects on protecting blood vessels, but sartan antihypertensive drugs have less effect than pril antihypertensive drugs in this regard. Therefore, for patients with coronary heart disease and hypertension, diabetic retinopathy, hypertension, heart failure, and hypertension, they can prefer Pril antihypertensive drugs as prescribed by doctors.
Side effects
The common side effect of active antihypertensive drugs is persistent dry cough. Patients may stop the medication because they cannot tolerate dry cough, but sartan antihypertensive drugs rarely cause dry cough in patients. Therefore, if the patient experiences a persistent dry cough after taking Priligy antihypertensive drugs, you can also change to sartan antihypertensive drugs as prescribed.
price
Priligy antihypertensive drugs are usually lower, and the price of sartan antihypertensive drugs is higher than that of Priligy. This drug will cause angioedema and increase blood potassium. Therefore, this drug should be prohibited for patients with hyperkalemia, hypertension during pregnancy or bilateral renal artery stenosis.
For the selection of Priligy-type antihypertensive drugs and sartan-type antihypertensive drugs, it is usually necessary to observe the specific antihypertensive effects and the patient's tolerance to adverse reactions, and make a decision according to the doctor's advice.
3
sacubitril Valsartan, which can reverse the ventricular structure and improve cardiorenal function. What should I pay attention to when taking
Sacubitril Valsartan sodium tablets are mainly used in adult patients with chronic heart failure with reduced ejaculation fraction, which can reduce the risk of cardiovascular death and hospitalization of heart failure in this type of patients.
sakubalivalsartan sodium tablets can also replace angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists to be used in combination with other drugs for treating heart failure, including beta receptor blockers, diuretics, mineralocorticoid antagonists, etc. Before taking the medication, you should pay attention to the following contraindications:
. This product is prohibited for patients who are allergic to any ingredient in sakubalivalsartan sodium tablets. Use it with caution for those with allergic constitutions and be vigilant about the occurrence of allergies.
. People who are taking ACEI are prohibited from using sakubalivalsartan sodium tablets. They must start taking this product after 36 hours of stopping ACEI treatment.
. Patients who have had a history of angioedema caused by ACEI or ARB treatment are prohibited from using sakubalivalsartan sodium tablets. Severe edema may also occur with this product, and patients with hereditary or idiopathic angioedema are also prohibited.
. Patients with type 2 diabetes who are taking Aliskiren are prohibited from taking this product.
5. Patients with severe liver function impairment, biliary cirrhosis, and cholestasis are contraindicated. This product may further aggravate these original diseases.
6. Pregnant women should use sakubalivalsartan sodium tablets with caution. This product may cause fetal damage and increase the incidence and mortality of fetal and neonatal babies. If you find pregnancy during the medication, you should also seek medical treatment immediately and consider changing the medication.
