Since penicillin entered the human world, various anti-inflammatory drugs have been invented one after another, which has enabled humans to make great achievements in fighting microorganisms and greatly reduced deaths caused by various microorganisms.
However, with the development of medicine, the abuse of anti-inflammatory drugs is everywhere in life . Therefore, the national government has strengthened the management of antibiotics. However, in real life, the abuse of anti-inflammatory drugs is still serious.
I believe that every family has a small medicine box, with at least one anti-inflammatory drug in it. No matter what problems many friends encounter, the first thing they take is anti-inflammatory drugs. In the eyes of these friends, anti-inflammatory drugs seem to be a powerful tool: to treat the disease and to defend themselves against the disease. But the reality is not as simple as you think. Let’s talk about this issue below.
The current use of antibiotics in my country
Since the discovery of penicillin in 1928, many serious diseases in the past have become very simple, which also makes people feel that anti-inflammatory drugs are omnipotent. Therefore, many friends have the idea " You should take it when you are sick." The misunderstanding of using anti-inflammatory drugs ".
In the past, patients often came to Dr. Zhang to ask for anti-inflammatory drugs. It seems that no matter what the disease is, you should use some anti-inflammatory drugs .
According to data, the probability of abusing anti-inflammatory drugs is as high as 50% in the world, especially in my country, where the probability of abusing anti-inflammatory drugs is as high as 80%. About 5% of outpatient cold patients in China use anti-inflammatory drugs, and the use rate of anti-inflammatory drugs among inpatients is as high as 0%. It's shocking how these numbers look..
It is undeniable that the discovery and use of antibiotics has indeed greatly improved the average life span of humans. However, everything has its degree, and going too far is not enough, and things will inevitably turn into the opposite . The same goes for the use of anti-inflammatories.
The World Health Organization pointed out that if the problem of abuse of antimicrobial drugs cannot be actively solved, more than 10 million people will die from antimicrobial-resistant infections every year around the world, and the number of deaths caused by the abuse of antibiotics may even exceed cancer.
What harm does the abuse of anti-inflammatory drugs cause to health?
Many friends believe that anti-inflammatory drugs have few side effects and do not take long, so taking them regularly is not a big deal. In fact, it's just the opposite. Let's talk about this issue in and . The harm of abusing anti-inflammatory drugs mainly comes from three aspects:
- Bacteria are severely drug-resistant
The discovery and application of antibiotics is a great revolution for mankind. But what friends need to know is: Whether they are humans or germs, in order to survive, they will continue to evolve and adapt themselves to the living environment . With the widespread use of anti-inflammatory drugs in clinical practice, -resistant soon appeared.
Therefore, when anti-inflammatory drugs are abused, those bacteria that have not been completely killed will become more powerful. This will lead to the fact that when bacteria are encountered again, the originally effective anti-inflammatory drugs will no longer be effective, and stronger anti-inflammatory drugs will be needed to be effective. This leads to a vicious cycle that ultimately results in no anti-inflammatory drugs being available. has led to the emergence of " super-resistant bacteria ". The final outcome is that there is no cure for and .
In addition, DNA contamination caused by the abuse of anti-inflammatory drugs is also another major factor that contributes to " super bacteria ". The types and numbers of bacterial resistance genes are increasing so rapidly that they cannot be explained by mutations.
Bacteria can not only exchange genes within the same species, but also between different species , and can even obtain genes from DNA scattered by dead conspecifics. As a result, drug-resistant genes spread rapidly among bacteria, which further promoted the emergence of " superbug ".
Without the availability of anti-inflammatory drugs, some diseases that could have been treated with anti-inflammatory drugs become untreatable. As a result, it becomes like before, it may be just a minor illness, but it becomes untreatable. If there is a crisis in the use of anti-inflammatory drugs, human health will be seriously threatened and again.
- Adverse reactions
As the saying goes, every gain must come with a loss. Although anti-inflammatory drugs are effective, like other drugs, they also have certain side effects. Many anti-inflammatory drugs not only inhibit or kill bacteria, but also inhibit or kill normal cells, so they can easily cause damage to the body.
At the same time, drugs enter the stomach through the mouth, are absorbed into the bloodstream through the intestines, and are transported to various cells in the human body. Only drugs that reach the lesion site can have an effect on bacteria. Drugs in other tissues not only have no effect, but It needs to be excreted from the body through the liver and kidneys. It will cause certain damage to the liver, kidneys and other organs along the way.
In addition, many anti-inflammatory drugs such as penicillin, streptomycin, and other drugs can also cause allergic reactions , ranging from mild rashes and fever to hematopoietic system inhibition, etc., and even damage the nervous system , severe cases Causes to shock , or even die.
Of course, drugs have certain side effects. They are beneficial to health only when the advantages outweigh the disadvantages. However, if is abused or used excessively, will lead to adverse reactions.
- Double infection
The abuse of anti-inflammatory drugs may also cause the imbalance of normal flora in the human body. Due to the influence of antibiotics, the types and quantities of various bacteria in the normal flora will change. Severe dysbiosis can lead to a series of clinical symptoms in the body, which is the so-called superinfection of in clinical practice, which in turn brings great trouble to the treatment of the disease and produces serious adverse consequences.
If antibiotics are used in large doses or for a long time, while inhibiting or killing some -sensitive bacteria , some insensitive bacteria may take the opportunity to multiply and cause new infections. The bacteria that cause new infections can be parasitic bacteria that are harmless to the body under normal circumstances. Due to changes in the flora, other harmless bacteria that can inhibit the growth of the bacteria are inhibited by drugs and turn into pathogenic bacteria. .
It is precisely because of these problems that many doctors believe that using anti-inflammatory drugs to treat infections is destined to be an unwinnable war. Of course, anti-inflammatory drugs have a very good therapeutic effect on many diseases. If necessary, they cannot be ignored because of these hazards. That would not be worth the gain and could lead to life-threatening consequences. So, what is the correct way to apply anti-inflammatory drugs?
How to use antibiotics rationally?
From the above description, friends can see that the abuse of anti-inflammatory drugs is very harmful. To reduce these harms, antibiotics must be used correctly and rationally. Four aspects need to be paid attention to:
- Symptomatic medication
- Select appropriate antibiotics based on the type of pathogenic bacteria, clinical symptoms and the antibacterial spectrum of the drug. Friends who have been hospitalized now will find that doctors especially like to check various bacteria-related tests, all in order to find suitable antibiotics for patients.
- Antibiotic selection based on site of infection and pharmacokinetics . For anti-inflammatory drugs to exert a bactericidal or bacteriostatic effect in the body, they must reach an effective drug concentration at the infected site. Therefore, the selection of anti-inflammatory drugs must be based on the concentration and maintenance time of the anti-inflammatory drug at the infected site.
- Drug selection is based on the patient's physiological, pathological and immune status. Different patients should use different anti-inflammatory drugs. Pregnant and lactating women should avoid taking drugs that can cause malformations and affect the development of newborns.
- Pay attention to the dosage and course of treatment
The dosage and frequency of anti-inflammatory drugs should be appropriate, and the course of treatment should be sufficient. Never use fueling tactics , which will only make your opponent (bacteria) more and more powerful. It is particularly important to note that the adverse reactions of drugs are closely related to the time and dosage of the drug, which is particularly important .
- Avoid preventive medication
In real life, the preventive application of anti-inflammatory drugs accounts for about 40% of the use of anti-inflammatory drugs, but in fact, only a few have application value, especially the use of anti-inflammatory drugs for viral infections. , will only cause drug resistance or secondary infection. Therefore, it is necessary to strictly apply preventive anti-inflammatory drugs . The purpose of
- combined application of
combination medication is to improve the treatment effect of the disease, reduce bacterial resistance , while reducing the occurrence of adverse reactions and expanding the antibacterial scope. However, the indications for combined use of antibiotics must be strictly controlled. It is safest to leave it to doctors and pharmacists.
Medical researchers pointed out: About 50% of anti-inflammatory drugs are abused in the world every year, and the proportion in China is even close to 80%.
In China, anti-inflammatory drugs are usually easily available without a prescription, which to a certain extent has led to abuse and misuse by ordinary people. Doctors have to use more powerful anti-inflammatory drugs when treating patients, which once again leads to the development of stronger drug resistance in bacteria. It is precisely due to the abuse of drugs that germs quickly adapted to the environment of anti-inflammatory drugs, and various "superbugs" were born one after another.
We always say that we should leave something to future generations, including wealth, forests, blue sky, etc., and hope that they will live a happy life. Now it seems that in addition to these things, we must also leave some anti-inflammatory drugs that can be used by future generations. In some ways, this may be even more important.
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