RSV infection is the primary factor in hospitalization for viral respiratory infection in infants and young children, and seriously endangeres children's health. It can be seen that respiratory syncytial virus infection should attract sufficient attention.

2025/05/2912:31:33 hotcomm 1003

Winter and early spring are the main epidemic seasons of respiratory syncytial virus (RSV). RSV infection is the primary factor in hospitalization of viral respiratory infection in infants and young children, and seriously endangeres children's health. 84% of children under 1 year old have been infected with RSV. It can be seen that respiratory syncytial virus infection with should attract sufficient attention.

What is respiratory syncytial virus ?

respiratory syncytial virus was isolated from the chimpanzee respiratory tract in 1956. Because it causes adjacent cells to fusion during cell culture, the cell lesions form a structure similar to syncytial , it is called respiratory syncytial virus.

In 2015, the International Virus Classification Commission changed the RSV to the genus of the Pneumovirus family Pneumovirus, and in 2016 renamed the human respiratory syncytial virus as human Pneumovirus.

RSV genome structure is single strand negative strand RNA. G and F proteins are two important antigenic proteins on the surface of RSV membranes. Among them, F proteins are highly conservative and are currently the hot protein for the development of antibodies, vaccines and therapeutic drugs. What are the symptoms after

infection?

A child's condition is different after RSV infection. It can be manifested as mild upper respiratory tract infection or otitis media , or severe lower respiratory tract infection . Age 12 weeks, chronic lung disease, congenital airway malformation, inconsistent throat function, left-to-right shunt type congenital heart disease , Down syndrome , immunodeficiency and neuromuscular diseases are high-risk groups that develop into severe diseases after RSV infection.

respiratory syncytial virus infection can cause the airway to secrete a large amount of mucus, causing airway obstruction; it can cause bronchial smooth muscle spasm; it is prone to airway hyperresponsiveness after infection, which is closely related to the later recurrent wheezing and the occurrence of asthma . Symptoms of upper respiratory tract infection caused by

RSV include nasal congestion, runny nose, cough, hoarseness, etc. Lower respiratory infections are mainly manifested as bronchiolitis and pneumonia.

The first 2-4 days of the disease usually show symptoms of upper respiratory tract infection, and then the symptoms of lower respiratory tract quickly appear, coughing and wheezing, which further aggravates shortness of breath, difficulty breathing (increased breathing), difficulty in breathing, difficulty feeding, mental depression, etc.

Most children infected with RSV can recover completely without leaving any sequelae, but children infected with RSV in infancy have four times the probability of developing asthma than healthy babies. RSV infection cannot produce permanent immunity and cannot protect children from reinfection.

References:

[1] Action initiative for the prevention and control of respiratory syncytial virus infection in children in Chinese [J]. Chinese Journal of Medicine, 2021, 101(36): 2861-2866.

[2] National Center for Clinical Medicine for Respiratory Diseases, Respiratory Group of the Pediatric Branch of the Chinese Medical Association, Pediatric Respiratory Working Committee of the Respiratory Physician Branch of the Chinese Medical Association, et al. Expert consensus on diagnosis, treatment and prevention of respiratory syncytial virus infection in children [J]. Chinese Journal of Practical Pediatric Clinical Medicine, 2020, 35(4): 241-250.

Source | First Pediatric Infection Department

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