Recently, the U.S. Food and Drug Administration (FDA) announced that adults and children who receive the mRNA new coronavirus vaccine produced by Moderna and Pfizer will increase the risk of heart inflammation such as myocarditis and pericarditis. And a warning about the risk of heart inflammation was added to the warning information for both vaccines. As of June, 1,226 cases of heart inflammation have been reported in people who have received both vaccines, mostly in young men.
A recent report proposed a more promising and safe delivery method for the mRNA COVID-19 vaccine-spermidine conjugates. It is worth noting that as a natural polyamine with anti-aging effects, spermidine has been proven to have significant cardioprotective effects in multiple experiments.
As early as 2016, the Austrian Institute of Molecular Bioscience published an article in "Nature Medicine" stating that spermidine has a very prominent protective effect on the heart. It can reduce myocardial hypertrophy and protect the diastolic function of elderly mice, and it has also been evaluated in population questionnaires. , a high-spermidine diet can reduce the incidence of hypertension and cardiovascular disease. Multiple research teams have explained the mechanism in detail, and it is generally believed that spermidine alleviates cardiac dysfunction by enhancing AMPK/mTOR-mediated autophagy and reducing apoptosis. The Chinese research team then proved that spermidine can activate the SIRT1/PGC-1α signaling pathway to improve cardiomyocyte aging and enhance mitochondrial biogenesis and function. A recent 2021 study from Hannover Medical School shows that spermidine supplementation for 6 months is sufficient to significantly attenuate multiple age-related phenotypes, including improvements in cardiac inflammation and confer the cardioprotective effects of spermidine on telomere attrition. Reduce links.
In short, the cardioprotective effect of spermidine has been widely recognized in the scientific research circle. It may be feasible to use spermidine to slow down the cardiotoxic side effects of the new coronavirus vaccine. Of course, in addition to middle-aged and elderly people, in the era of punk health care, young people may be more concerned about heart health.
[Reference]
1. Eisenberg T, Abdellatif M, Schroeder S, et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016;22(12):1428-1438.
2. Wang J, Li S , Wang J, et al. Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function. Aging (Albany NY). 2020;12(1):650-671.
3. Wirth A, Wolf B, Huang CK, et al. Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length. Geroscience. 2021;43(2):673-690.
4. Yan J, Yan JY, Wang YX, et al. Spermidine-enhanced autophagic flux improves cardiac dysfunction following myocardial infarction by targeting the AMPK/mTOR signaling pathway. Br J Pharmacol. 2019 Sep;176(17):3126-3142.
5. Nilsson BO, Persson L. Beneficial effects of spermidine on cardiovascular health and longevity suggest a cell type- specific import of polyamines by cardiomyocytes. Biochem Soc Trans. 2019 Feb 28;47(1):265-272.
