Recently, a video posted by an online blogger that a baby turned into a " big head doll " after using a bacteriostatic cream was posted on Weibo hot searches and attracted many people's attention. According to the video of
, a 5-month-old baby girl turned into a "big-headed doll" weighing 22 kg after using a certain antibacterial cream, with symptoms such as developmental delay, hirsutism, and enlarged face.
professional agency testing found that the product had illegally added "clobetasol propionate" glucocorticoid , the addition amount was 30mg/kg (which is hundreds of times that of some ordinary cosmetics with illegal addition of hormones).
On the 8th, the local health committee responded that the company had been ordered to suspend production and recall all products involved, and the incident is under further investigation.
So, what kind of drug is clobetasol propionate? What effect will it have on the human body when used? Next, I will explain it in detail.
What kind of drug is clobetasol propionate?
Clobetasol Propionate is a synthetic prednisone derivative that can quickly penetrate the stratum corneum of the skin. It is currently a highly effective topical glucocorticoid commonly used in clinical practice.
Clobetasol propionate has higher specificity for glucocorticoid receptors than mineralocorticoid receptors, and has strong anti-inflammatory, anti- itching , anti-allergic, anti-epidermal hyperplasia and shrinking capillary effects. The anti-inflammatory effect is about 112 times that of natural glucocorticoid (hydrocortisone), 18.7 times of fluocinolone, and 2.3 times of betamethasone sodium phosphate.
Therefore, clobetasol propionate is used to treat chronic eczema , psoriasis, palm and plantar pustulosis, lichen planus, neurodermatitis and other non-infectious inflammation skin diseases.
What are the effects of clobetasol propionate on the human body?
Clobetasol propionate is safe to use correctly according to the doctor's advice!
clinically usually use various compound preparations or sprays made of 0.05% clobetasol propionate for external treatment, twice a day, usually the treatment time should be limited to four weeks as a course of treatment.
The side effects of medication according to the doctor's prescription usually include local flushing, itching, scaling, edema , mild tingling, skin atrophy, local pigmentation or hypopigmentation, etc., generally do not affect the continued medication, and there is no systemic adverse reaction .
improper use may cause systemic adverse reactions!
clobetasol propionate topical can be absorbed through the intact skin, mainly metabolized by the liver and excreted by the kidneys. Frequent local use can cause folliculitis, hypopigmentation, acne-like rash, allergic contact dermatitis, secondary infection, perioral dermatitis, , and milia.
topical hormones can be absorbed into the blood through the skin, and low-dose use can inhibit the hypothalamic-pituitary-adrenal (HPA) axis.
long-term high-dose use can cause systemic hormonal adverse reactions. causes increased blood sodium and decreased blood potassium, leading to cataracts, glaucoma, edema, inducing digestive system ulcers, pancreatitis, myopathy, osteoporosis, adversely affecting mood, affecting metabolism, and inducing high blood pressure and hyperlipidemia , The formation of full moon face , and growth and development are inhibited, susceptible to infection.
Therefore, it is important to use clobetasol propionate rationally under the guidance of a doctor and strictly follow the course and method of treatment!
How to distinguish between buying cosmetics?
Regarding the illegal addition of hormone drugs to skin care products, we should choose products produced by regular manufacturers, and do not be superstitious about the amazing effects of certain "special effects drugs". When choosing skin care products, you can pay attention to its approval number.
Common cosmetics on the market can be divided into"Machine font size" and "makeup font size" products.
cosmetics are usually registered as "makeup fonts", divided into special cosmetics and ordinary cosmetics. and all "makeup brand" products can only be produced after being filed with the Food and Drug Administration, and the ingredients contained are required to be marked on the packaging.
"Machine font size" has higher requirements than "makeup font size". must be manufactured in accordance with national medical device standards to ensure its safety and effectiveness, and all have been tested by clinical observation and testing, and do not contain hormones and antibiotics. Allergic substances.
"Zhuangzi" and "Machine" products are registered and filed by the State Food and Drug Administration, and they are all skin care products that can be used.
The function of the " elimination " product in this incident is only used for in vitro sterilization and disinfection. It has been reviewed and approved by the local health department. It is a sanitation and disinfection product with the lowest degree of control.
Therefore, when purchasing skin care products, you can choose "makeup font size" and "machine font size" products according to the skin condition, and "eliminating font size" products generally cannot be used for conventional skin care.
Finally remind everyone that when shopping for skin care products, you must "clean up" your eyes!
Expert of this article: Dr. Tian Jing, Attending Physician, Center for Disease Control and Prevention of the Southern Theater Command
Reviewer of this article: Chen Haixu, Second Medical Center of PLA General Hospital, Associate Researcher, Associate Professor
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