BrainTalking︱生物鐘協調內在狀態與外界感知的神經機制（劉強博士後）

2024年11月01日09:10:16 科學 7131

找實驗方法，上腦聲常談

責編︱王思珍

“邏輯神經科學”一作面對面系列講座

（第九期）

晝夜節律篇 & 生物鐘篇 & 感知科學篇

BrainTalking︱生物鐘協調內在狀態與外界感知的神經機制（劉強博士後） - 天天要聞

講座題目：生物鐘協調內在狀態與外界感知的神經機制（molecular and circuit mechanisms mediating clock regulation of internal states and sensory perception）

主講人：劉強博士後美國約翰斯·霍普金斯大學

主持人：王強強（王思珍） 主編邏輯神經科學

時間：2024年11月6日（星期三）20:00-21:00（北京時間）

贊助：上海欣軟（腦聲常談）

學術支持：《cns neuroscience & therapeutics》、《ibrain》、《neuroprotection》、《brain-x》、《advanced science》。

技術支持：蔻享學術直播平台

報名參會：請添加主編微信：wang_sizhen，並備註：姓名+常用郵件+一作講座，獲取會議密碼。

講座摘要（abstract）

i mainly focused on using mwake as a genetic entrée to investigate the molecular and circuit basis of rhythmic behavior. we first showed that mwake acts as a clock-dependent brake on arousal during the night. rather than a simple model whereby the clock acts in a uniform manner to promote arousal during an animal’s active phase and enhance sleep during their quiescent phase, we found that the clock has a mixed approach to generating rhythmic arousal. our data suggest that specific molecules and circuits under clock control actively oppose the dominant sleep/arousal rhythms, in order to shape the appropriate level of arousal. following this work, i focused on studying the physiological and molecular mechanisms related to a local brain oscillator in the lateral amygdala (la) and how it rhythmically coordinates different behaviors. in addition to cyclical clock gene expression, brain oscillators should also exhibit rhythms of electrical activity. however, no genetic marker exists that labels electrically rhythmic neural circuits. in this project, we first showed that mwake is enriched in a molecularly-defined subregion of the la (anterior-dorsal la/adla). although the core clock protein per2 cycles throughout the la, we show that only mwake-positive, but not mwake-negative, adla neurons exhibit rhythmic intrinsic excitability. surprisingly, impairing clock function or glutamate signaling in adlamwake neurons eliminates per2 cycling in a non-cell autonomous manner throughout the la. at a molecular level, the mechanisms mediating rhythmic excitability outside of the scn are poorly understood. we show that mwake levels rise at night in adla^mwake neurons and upregulate bk current to inhibit the excitability of these cells at night. finally, we show that, rather than modulating an individual behavior, adla^mwake neurons utilize distinct projections to produce clock- and mwake-dependent rhythmic changes in two different behaviors: touch sensitivity and internal anxiety-like behavior. our investigation of the first discrete extra-scn brain oscillator also reveals new insights into the nature of the circadian timing network.

主講人簡介：