Japanese researchers recently announced that they have developed an experimental system that can measure the lifespan of plasma cells produced by experimental mice, achieving long-term tracking of the survival status of plasma cells in experimental mice, and thus clarifying the m

Japanese researchers recently announced that they have developed an experimental system that can measure the lifespan of plasma cells and cells that produce antibodies in experimental mice. They have achieved long-term tracking of the survival status of plasma cells in experimental mice, and then clarified the mechanism of the birth of long-lived plasma cells. This result will help explain why the duration of effect of vaccine is different. If it can effectively induce long-lived plasma cells, it is expected to help develop a vaccine with longer lasting effect.

data map source: Xinhua News Agency

Plasma cells can secrete specific immunoglobulins, that is, antibodies, under the stimulation of antigen , and release them into the blood. A press release issued by Osaka University in Japan stated that the medical community generally believes that the duration of the protective effect of vaccines depends on the lifespan of plasma cells. However, there has been no method in the medical community to track the survival status of plasma cells, so people have little understanding of the characteristics of long-lived plasma cells.

Researchers from Osaka University in Japan and other institutions have developed an experimental system that can label plasma cells in experimental mice with fluorescent dyes, and used this system to track the survival status of plasma cells in experimental mice for up to one year. They found that most of the newly born plasma cells will die quickly, while a small number of plasma cells will transform and survive quietly in the bone marrow to become long-lived plasma cells. The

communiqué stated that this research made it possible to isolate long-lived plasma cells and explore their induction mechanism in detail. Based on this result, it is expected to develop a vaccine with longer-lasting effects by efficiently inducing long-lived plasma cells. The research results related to

have been published on the website of " Journal of Experimental Medicine " in the United States.

(Original title: Japanese researchers discover long-lived plasma cells that continue to produce antibodies)

Source: Xinhua News Agency

Process Editor: TF016