Since the outbreak at the end of 2019, the new coronavirus (SARS-CoV-2) has posed an extremely serious threat to human life and health and the stable development of society. Therefore, the search for broad-spectrum and high-efficiency anti-coronavirus drugs has become a key scientific problem in this field that needs to be solved urgently. Recently, the team of Professor Shuwen Liu from the Southern Medical University School of Pharmacy and Fudan University and Guangzhou Medical University have collaborated to elucidate the role and mechanism of acid anhydride-modified proteins against the new coronavirus. The relevant results are in the Nature sub-publication Signal Published online on Transduction and Targeted Therapy (IF: 18.187).
The paper is entitled "Repurposing of a clinically used anti-HPV agent to prevent and treat SARS-CoV-2 infection as an intranasal formulation". Professor Jiang Shibo of Fudan University, Professor Yang Zifeng of Guangzhou Institute of Respiratory Health/State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, and Guangzhou National Laboratory are the co-corresponding authors of this article. Professor Li Lin of School of Pharmacy of Southern Medical University participated in the research of this project. . The project was supported by the National Natural Science Foundation of China and the Guangdong Provincial Natural Science Foundation team project.
Professor Jiang Shibo of Fudan University and Southern Medical University Professor Shuwen Liu in an early collaborative study found that many common animal or human proteins can be modified by acid anhydrides to antagonize the invasion of multiple viruses through the effect of positive and negative charges. Cell,Including HIV, HPV, MERS-CoV, etc., and these unmodified proteins do not have antiviral activity. Among them, β-lactoglobulin (β-LG) extracted from milk has been modified by 3-hydroxyphthalic anhydride (3HP), and 3HP-β-LG has been successfully developed as an anti-HPV biological protein dressing (National Second Class medical equipment), used in more than 1,100 hospitals in 23 provinces, municipalities and autonomous regions across the country, and has a positive effect on high-risk HPV infections in the reproductive tract.
3HP-β-LG's anti-SARS-CoV-2 effect and mechanism of action B.1.1.7, B.1.351, P1, B1.617.1 and other SARS-CoV-2 mutant pseudoviruses with strong sex and low neutralizing antibody sensitivity also have an inhibitory effect. The mechanism of action of the acid anhydride modified protein, through experimental studies, is speculated to be that 3HP-β-LG binds to the new coronavirus S protein, competitively blocking the binding of the S protein to the ACE2 receptor, thereby inhibiting the virus from invading target cells. Therefore, 3HP-β-LG is very likely to be developed into a new class of cheap and safe anti-new coronary pneumonia drugs delivered through the nose, providing a new and powerful means for clinically fighting the new crown epidemic.
Liu Shuwen, professor and doctoral supervisor. The current vice president of Southern Medical University, selected into the National Hundred and Thousand Talents Project, young and middle-aged experts with outstanding contributions, National Innovation Promotion Program "Young and Middle-aged Technology Innovation Leading Talents", Guangdong Special Support Program "Hundreds and Thousands of Engineering Leaders", Guangdong Province "Pearl River Scholars" Distinguished Professors of Universities and Outstanding Talents in the New Century. Won the second prize of Guangdong Science and Technology Progress Award and the second prize of Guangdong Teaching Achievement Award.
At the beginning of the new crown epidemic, the Southern Medical University School of Pharmacy led by Professor Liu Shuwen has been struggling to be at the forefront of scientific research.The team discovered that various compounds such as salvianolic acid C, itraconazole, estradiol benzoate, and potato triose oleanolic acid saponins have good anti-new coronavirus activity in vitro. team member Professor Li Lin published a paper in Frontiers in Pharmacology (IF: 5.810) earlier this year, confirming that another acid anhydride modified protein, namely 3-hydroxyphthalic anhydride modified chicken ovalbumin (HP-OVA), was approved by Guangzhou The team of Professor Yang Zifeng of the Medical University found that can effectively inhibit the infection of the new coronavirus live virus. Based on these foundations, Liu Shuwen's team applied for the National Natural Science Foundation of China in 2021. The key project "Discovery, structural modification and mechanism of anti-coronavirus targeting virus S protein membrane fusion region" was granted project funding.
Further reading:
School of Pharmacy, Southern Medical University is a school established in June 2005 after the original First Military Medical University was transferred to Guangdong Province. Currently, the college has two undergraduate majors: pharmacy (four-year program) and clinical pharmacy (five-year program). Pharmacy is a famous specialty in Guangdong Province. In 2019, it was approved as the first batch of national first-class undergraduate professional construction sites . In October 2019, it was the first to pass the pharmacy professional certification with new standards. Clinical Pharmacy Specialty was approved as a national first-class professional construction site in 2020.
In the past five years, the college has undertaken 227 national, provincial and municipal projects, with research funding of 168 million yuan. Published more than 580 SCI papers in internationally renowned journals ,It has applied for and obtained more than 130 national invention patents and international PCT patents, of which 76 were authorized. Won 1 second prize of scientific and technological achievement award of Guangdong Pharmacological Society. Won one second prize of Provincial Teaching Achievement Award. Won 19 educational research projects above the provincial level. Published 56 teaching papers . 29 textbooks have been compiled, including 11 editor-in-chief and deputy editor-in-chief. (Data as of May 2021)
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Some sources of materials: Southern Medical University News Network, Southern Medical University School of Pharmacy official website
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