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Content summary
On December 7, 2022, a study published in the journal "Neurology" showed that cholesterol-lowering drugs are associated with a reduced risk of stroke cerebral hemorrhage Statins are used longer and have a lower risk.
Research screenshot
Current status
David, a member of the University of Southern Denmark Odense and the American Academy of Neurology, is also the author of the study Dr. Gaist said:
While statins have been shown to reduce the risk of blood clots in stroke, there have been conflicting studies on whether statin use increases or decreases a person's risk of a first brain bleed;
In our study, we looked at the lobes of the brain and non-lobar regions to see if location is a factor in statin use and the risk of first brain hemorrhage;
We found that people who used statins had a lower risk of this type of hemorrhagic stroke in two areas of the brain;
The risk was even lower with long-term statin use.
Conclusions
This study identified 989 patients with lobar intracerebral hemorrhage (ICH) (52.2% female, mean age 76.3 years) and matched them to 39,500 controls, and 1,175 non-lobar ICH patients (46.5% female, mean age 75.1 years) and matched them to 46,755 controls.
The study found:
Current statin use was associated with lower risk of lobar (aOR 0.83) and non-lobar ICH (aOR 0.84);
Longer statin use was also associated with lower lobar risk (1 year: aOR 0.89; ≥1 to 5 years aOR 0.89; ≥5 years aOR 0.67; p indicates trend 0.040) and non-large leaf ICH (1 year: aOR1.00; ≥1 to 5 years aOR 0.88; ≥5 years aOR 0.62; p indicates trend 0.001);
Estimates stratified by statin intensity were similar to the main estimates for low- and moderate-intensity treatment (lobe aOR 0.82; non-lobe aOR 0.84);
The association with high-intensity treatment was neutral.
Outlook
That said, long-term statin use is associated with a lower risk of stroke in two areas of the brain. When taking statins for more than five years, people had a 33% lower risk of stroke in lobar areas of the brain and a 38% lower risk of stroke in non-lobar areas of the brain.
Gaist added:
For people taking statins, it is reassuring news that these drugs appear to reduce the risk of bleeding strokes as well as the risk of thrombotic strokes;
However, our study was only conducted in a Danish population, mainly people of European ancestry, and more studies should be conducted in other populations in the future.
