Introduction: " Photosynthesis " is moved into animal cells, allowing senescent cells to return to their youth; Rongchang Bio RC118 has been recognized by the US FDA for two orphan drugs... Biological Exploration will pay attention to the "medicine" news with you and explore the value of biotechnology!
01 "Photosynthesis" moves into animal cells,
brings senescent cells back to youth
Recently, the latest issue of " Nature " published a study. This cross-border strategy successfully treated osteoarthritis in mice, allowing their aged joint chondrocytes to restore youth. In the future, this technology is expected to treat more degenerative diseases of aging. The plant's thylakoid is migrated across the border into mammalian cells, and the anabolic metabolism of animal cells is enhanced by the help of "photosynthesis"; the animal's own cell membrane is used to wrap the thylakoid. With this layer of camouflage, the thylakoid can successfully "scam" the cells and successfully reach the inside of the cells.
02 Rongchang Bio RC118 was awarded two orphan drug qualifications for
FDA in the United States. On December 8, Rongchang Bio announced that the company's injection RC118 was awarded two orphan drug qualifications issued by the U.S. Food and Drug Administration (FDA), targeting gastric cancer (including gastroesophageal junction cancer) and pancreatic cancer indications respectively. RC118 for injection is an innovative antibody-conjugated drug (ADC) independently developed by Rongchang Bio, used to treat patients with locally advanced unresectable or metastatic solid tumors with positive expression of Claudin 18.2.
This product was approved for the Phase I clinical trial of the National Drug Review Center (CDE) in September 2021. Currently, dose climbing studies are being conducted and have shown good safety and tolerance.
03 Depression new drug failed again,
stock price fell 40%
December 7, Relmada Therapeutics announced that the Phase III RELIANCE-I study of REL-1017 used for adjuvant treatment of major depression (MDD) failed to reach its main endpoint, and the symptoms of depression did not improve significantly, and the stock price fell nearly 40% as a result, and the current market value is only about US$134 million. NMDA is a chemical that can open channels similar to the physiological neurotransmitter glutamate . Studies have shown that NMDA receptor is involved in the occurrence of depression and normal physiological functions. REL-1017 (dexamethadone) is a novel NMDA receptor channel blocker that preferentially targets GluN1-GluN2D hyperactive channels while avoiding inhibition of other channels with normal physiological functions.
04 concept stock floods the screen A shares , ursodeoxycholic acid
is really a "shock" in the fight against the epidemic?
Recently, a new concept sector appeared in in A-share market - ursodeoxycholic acid. Among them, Xuantai Pharmaceutical, the leader in concept stocks, recorded two consecutive boards, with the stock price rising by as high as 43.98%. Although ursodeoxycholic acid has not yet been determined whether it can prevent the virus, concept stocks in the A-share market have fermented. From December 7 to 8, the stock prices of Xuantai Pharmaceuticals, Xinhua Pharmaceuticals, Gonggong Pharmaceuticals, Shanghai Kaibao and other companies rose for two consecutive days.
Ursodeoxycholic acid concept emerged from a research paper published by researchers at the University of Cambridge in the UK on Nature. The study found that ursodeoxycholic acid (UDCA), a drug for treating liver disease, closed the door to the new coronavirus entering cells - the ACE2 receptor. Since this drug targets host cells rather than viruses, it may prevent new variants of the virus, as well as other coronaviruses, , that may appear.
05 Self-amplifying mRNA vaccination
pathway regulates efficient T cell response
Recently, a research team from the Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, published a research article "Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells" in the journal Science Immunology. The correlation of antigen-specific CD8 and CD4 T cells and serum antibody responses with immune pathways after inoculation with self-amplified mRNA encoding influenza nucleoprotein (NP) encapsulated with modified DNA-based nanoparticles (MDNPs).
Organized|Qiao Weijun
Typeset|Qiao Weijun
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