2 December 03 "Voice of Mother and Baby", we interpreted 10 literatures, focusing on: endometritis , gestational diabetes, intestinal flora , vaginal flora, endometrial cancer, autism, exposure group, streptococci alactis, inflammatory enteritis, drug prediction, assisted reproduction.
Jilin University team: A great discussion on the benefits of C. butyric acid in endometritis
Microbiology spectrum—[9.043]
①The mouse model of endometritis induced by E. coli , and the pathology of HT can be reversed by the pretreatment intervention of C. butyric acid; ② At the same time, C. butyric acid treatment can reduce the production of proinflammatory mediators, as well as the levels of bone marrow peroxidase and propylene glycol ; ③ Clostridium butyric acid can inhibit the TLR4-mediated activity of NF-κB phosphorylation of and histone deacetylase , increasing the expression of tight junction proteins ZO-1, claudin-3 and occludin; ④ Treating mice with culture supernatant of Clostridium butyric acid can also inhibit the degree of intrauterine inflammation, while the inactivated Clostridium butyric acid does not play a protective role.
[Editor's comment]
An animal study by the research team of Jilin University found that Clostridium butyric acid can maintain the function of the intrauterine epithelial barrier and inhibit the inflammatory response, so it has a potential role in the prevention and treatment of endometriitis. And its protective effect may be related to the production of butyrate. (@Epi Wang)
[Original information]
Protective Effect of Clostridium butyricum on Escherichia coli-Induced Endometriitis in Mice via Ameliorating Endometrial Barrier and Inhibiting Inflammatory Response
2022-11-02, doi: 10.1128/spectrum.03286-22
Domestic team: Gestational diabetes increases the risk of childhood obesity by affecting the intestinal flora
mSystems—[7.324]
① 60 pregnant women with gestational diabetes (GDM) and 60 healthy controls were included, and the neonatal meconium was collected and followed up for 12 months of age in children BMI; ② The BMI z-score in the GDM group increased, and the β diversity of the meconium flora decreased; ③ Among them, the Burkholderia-Caballeronia-Paraburkholderia and several strains of the Eczema family bacteria were higher in the control group, which was negatively correlated with BMI; ④ A group of bacteria associated with GDM (CAG4) mediated the association between GDM and infant BMI, with mediating effects accounting for 21.65%; ⑤ GDM may increase the risk of childhood obesity by affecting the intestinal microbiota of the newborn.
[Editor's comment]
Nanjing Medical University Research team constructed a gestational diabetes cohort and found that pregnant women with gestational diabetes may increase BMI during their development by changing the meconium flora structure of neonatal children. This study provides new ideas for revealing the association between GDM and offspring health. (@Epi Wang)
[Original information]
Role of the Gut Microbiota in the Increased Infant Body Mass Index Induced by Gestational Diabetes Mellitus
2022-10-26, doi: 10.1128/msystems.00465-22
Domestic team: The association between postpartum pelvic floor function and vaginal flora
Frontiers in Microbiology——[6.064]
① 230 postpartum women were included, and vaginal swabs were collected to evaluate the postpartum pelvic floor function; ② The proportion of urinary incontinence in women with postpartum pelvic floor muscle weakness was higher, and factors such as vaginal delivery, overweight, advanced age, neonatal weight and weight gain during pregnancy were all risk factors for postpartum urinary incontinence; ③ The vaginal flora of most postpartum women is no longer dominated by , and vaginal microbial diversity increased; ④ The abundance of Lactobacillus vaginal in the group with impaired pelvic floor muscle function decreased, and species diversity and richness increased; ⑤ Future studies should further determine the association between pelvic floor function and female vaginitis.
[Editor's Comment]
Through follow-up observation of postpartum women, this study found that those with worse pelvic floor function recovery often have a decrease in Lactobacillus in the vaginal flora, suggesting that there may be an association between the two. However, the causal relationship is not clear and needs further exploration and confirmation.(@Epi Wang)
[Original information]
The relationship between pelvic floor functions and vaginal microbiota in 6-8 weeks postpartum women
2022-11-03, doi: 10.3389/fmicb.2022.975406
Domestic team: Intestinal microbiota and fatty acid metabolism participate in the progression of endometrial cancer
Microbiology spectrum——[9.043]
① 18 endometrial cancer patients and 18 controls were included, and their intestinal flora were detected. They found that the intestinal flora structures of the two groups were different; ② The plasma metabolites found that the C16:1 and C20:1 metabolites in the case group were elevated, which was positively correlated with the abundance of rumenococci N15.MGS-57 in the intestinal tract; ③ In addition, rumenococci was negatively correlated with the biosynthesis of betaine and indole alkaloids; ④ The combined markers of intestinal flora, blood metabolites and clinical indicators, a prediction model of molecular endometrial cancer can be constructed; ⑤ The spatial metabolites showed that C16:1 and C18:1 aggregation in tumor tissues may promote the invasion of EC cells through mTOR signal.
[Editor's Comment]
This study found the biomarker , which may be involved in endometrial cancer, through detection of intestinal microbiota and metabolomic group. Through spatial metabolite analysis, it was found that C16:1 has a potential marker effect. This study provides a basis for further developing prediction and diagnostic models for endometrial cancer. (@Epi Wang)
[Original information]
Altered Gut Microbial Profile Accompanied by Abnormal Fatty Acid Metabolism Activity Exacerbates Endometrial Cancer Progression
2022-10-13, doi: 10.1128/spectrum.02612-22
Domestic team: Perinatal supplementation of melatonin may be used to treat offspring autism
Biomedicine and Pharmacotherapy——[7.419]
① The model of valproic acid inducing autism mice was used to detect social function defects and intestinal flora disorders in their offspring mice; ② Supplementing melatonin in the late pregnancy and lactation period can restore the social function defects in the offspring mice; ③ In addition, the intestinal flora has a certain degree of recovery, which is reflected in the upregulation of the abundance of Ackermans; ④ Supplementing Ackermans found that it can activate dopaminergic neurons in the ventral tegmental area and alleviate the social function defects caused by valproic acid; ⑤ Melatonin may be able to achieve therapeutic effects on autistic mice by regulating the intestinal flora.
[Editor's Comment]
Through systematic animal experiments, this study preliminarily confirmed that melatonin supplementation can have an intervention effect on autism by changing the intestinal microbiota. (@Epi Wang)
[Original information]
Rescue of social deficits by early-life melatonin supplementation through module of gut microbiota in a murine model of autism
2022-11-01, doi: 10.1016/j.biopha.2022.113949
Nature Sub-job: Multiomics study to investigate the biomarkers of maternal and infant exposure group
Nature Communications——[17.694]
① The HELIX project included 1301 maternal and infant cohorts, and more than 100 exposures during pregnancy and childhood were investigated and tested, including chemicals, socioeconomics, lifestyles, etc.; ② The individual genome, methylated group, transcription group, protein group, plasma/urine metabolic group, etc. were detected and analyzed; ③ 1,170 associations were found, of which 249 were in pregnancy and 921 were in childhood, revealing potential exposure markers; ④ Smoking, cadmium and molybdenum exposure during pregnancy were mainly related to childhood DNA methylation; ⑤ The serum metabolome in childhood may be related to factors such as diet, toxic compounds, necessary trace elements and weather conditions.
[Editor's Comment]
A major study published in Nature Communications Human Early Life Exposome (HELIX) integrates data from six European cohorts to mine potential biomarkers of maternal and infant exposure, providing important clues for further research. The author has built a website https://helixomics. isglobal.org/ for this project. Interested readers can download some data.(@Epi Wang)
[Original information]
Multi-omics signatures of the human early life exposure
2022-11-21, doi: 10.1038/s41467-022-34422-2
New exploration of the pathogenic mechanism of Streptococcus alactis infection in women
mBio——[7.786]
① Streptococcus alactis (GBS) can be infected ascending during pregnancy. Once phagocytosis is engulfed by macrophage , GBS will upregulate the expression of the NADH peroxidase gene npx; ② The npx-deletion mutant strain (△npx) is very sensitive to reactive oxygen species stress and is easily engulfed by macrophages. After infecting animal tissue, the cytokine production is reduced; ③ This study proves that npx is necessary for GBS to survive in placental macrophages and is crucial for inducing the occurrence of diseases (including premature rupture of membranes, premature birth, etc.); ④ npx may be a key site for preventing invasive infection of GBS.
[Editor's comment]
Streptococcus infection in female reproductive tract group B during pregnancy has always been a topic of concern. The specific mechanism of its pathogenicity has not been fully revealed, resulting in the lack of clear prevention and intervention measures. This study demonstrates that npx is necessary for GBS to survive in placental macrophages through mutations in NADH peroxidase gene and a series of studies. Therefore, future research may use it as an intervention target. (@Epi Wang)
[Original information]
Streptococcus agalactiae npx Is Required for Survival in Human Placental Macrophages and Full Virulence in a Model of Ascending Vaginal Infection during Pregnancy
2022-11-21, doi: 10.1128/mbio.02870-22
Risk association of inflammatory bowel disease and adverse pregnancy outcomes
EClinicalMedicine—[17.033]
① Swedish women who were diagnosed with inflammatory bowel disease (IBD) between 1990 and 2016 were included in the Swedish women who were diagnosed with inflammatory bowel disease (IBD) before pregnancy to determine whether there was histological inflammation; ② Pregnant women with positive histological inflammation had a higher risk of premature birth than those with negative pregnant women (9.6% vs 6.5%); ③ In ulcerative colitis and generalized colitis, histological inflammation was positively correlated with premature birth risk, but no association was observed in Crohn's disease ; ④ There was no statistically significant correlation between histological inflammation and the risk of infants below gestational age; ⑤ Clinical activity of IBD before pregnancy was related to the risk of premature birth, but it was not related to infants below gestational age.
[Editor's comment]
Through the observation and analysis of the national pregnancy cohort, this study found that the risk of adverse pregnancy outcomes such as premature birth in women with inflammatory bowel disease in different categories is not consistent. This study provides new data to guide pregnancy management in women with inflammatory bowel disease. (@Epi Wang)
[Original information]
Histological remission in inflammatory bowel disease and risk of adverse pregnancy outcomes: A nationwide study
2022-11-06, doi: 10.1016/j.eclinm.2022.101722
Drug potential prediction, helping drug research in special populations
BMC Medicine——[11.15]
① This project has developed a TPP system that can screen candidates for preventing or treating preeclampsia; ② A total of 153 candidate drugs were identified in the drug candidate research and development database, of which 87 were in the clinical development stage; ③ Seven drugs were considered to have high potential, namely esomeprazole , L-arginine , chloroquine , vitamin D, metformin , as well as therapeutic drugs sulfasalazine pyridine and metformin; ④ Class 8 drugs were identified as moderate potential; ⑤ 66 candidate drugs were still in the preclinical development stage, the most common ones were amino acid /peptide, siRNA-based drugs and polyphenol .
[Editor's Comment]
Since pregnant women are special groups, many clinical trials cannot include pregnant women, resulting in the lack of drug safety data for pregnant women. This study uses the TPP system developed to analyze potential preeclampsia candidates on the market, and further analyzes and explores these drugs, providing important data support for the next step of drug development.(@Epi Wang)
[Original information]
Systematic evaluation of the pre-eclampsia drugs, dietary supplements and biologicals pipeline using target product profiles
2022-11-04, doi: 10.1186/s12916-022-02582-z
Assisted reproductive regimen may affect the risk of hypertensive diseases during pregnancy
BJOG: An International Journal of Obstetrics and Gynaecology——[7.331]
① Women who received frozen-thaw embryo transfer were included, and those who took the natural cycle, stimulation cycle (SC), and hormone replacement cycle (HRC) regimens were divided into 776, 758, and 3646; ② In single pregnancy, compared with women in natural cycle, the incidence of early pregnancy bleeding (OR=2.23), simple hypertension (OR=2.5), and preeclampsia (OR=2.16) in HRC group were all increased; ③ At the same time, compared with women in SC group, the risk of bleeding and preeclampsia in HRC group also increased; ④ In twin pregnancy, the risk of preeclampsia in HRC women was significantly increased; ⑤ If feasible in clinical practice, natural cycle or stimulation cycle should be recommended first.
[Editor's comment]
This study explores the risk changes in women with frozen-thaw embryo transfer under different cycle regimens for pregnancy during pregnancy through real-world evidence. This study has certain reference value for the selection of treatment plans for reproductive centers. (@Epi Wang)
[Original information]
Hormone replacement cycles are associated with a higher risk of hypertensive disorders: retrospective cohort study in singleton and twin pregnancies
2022-11-13, doi: 10.1111/1471-0528.17343
Thanks to the creator of this issue of the daily report: Epi Wang
Click to read the daily report in the past 5 days:
11-25 | The new coronavirus affects fertility? Facts or rumors?
10-29 | The alarm bell sounds! Hypertension during pregnancy has a profound impact on offspring!
