When the wealthy "world richest man" Bezos spent $3 billion to return to the peak of life with unfathomable reprogramming technology; when top scientists from all over the world spent a lot of energy and expenses to study complex and dangerous genes and cell technologies...
Yale scientists "get a big pound" and found a way to fight aging in basic dietary exercises, which was cheap and significant. The scientific research published in the authoritative journal Aging shows that in just 8 weeks, the subjects' physiological age index was "young" over 3 years old! [1]
Yale University Scientific Research: 2 months of physiological age reversal 3 years old
In the experiment, the Yale team recruited 43 adult men aged 50-72 and divided them into two groups. The control group maintained a daily diet, and the experimental group only needed to eat according to the recipe and then make a little adjustment in lifestyle.
recipes are as follows: Eat 3 servings of liver (about 85g per serving), 5-10 eggs, 2 cups of cruciferous vegetables ( broccoli , cabbage, cauliflower , etc.), 2 cups of dark green leafy vegetables (such as cabbage, spinach, mustard ), etc. Postprandial supplementation of DNA methyltransferase polyphenol regulators.
In addition, in terms of lifestyle: do two breathing exercises a day, sleep for no less than 7 hours per night, and maintain higher intensity aerobic exercise for at least 30 minutes at least 5 days a week.
8 weeks later, the experiment ended. The research team collected the saliva of the subjects. through accurate Horvath methylation clock measurement found that compared with the control group, the average physiological age of the experimental group was 3.23 years younger.
and blood test results also showed that the total cholesterol in the experimental group was reduced by 0.591mmol/L, the low-density lipoprotein cholesterol was reduced by 0.435mmol/L, and the triglyceride level was reduced by 25%, which means that their lipid metabolism ability was equivalent to that of young people. The result of
has amazed the scientific community and even led to a wave of experiments returning to nature.
What substances are showing their powers behind daily diet?
Why did Yale's experiment eat common foods and just make simple adjustments to the work and rest, but it can be 2 months younger and 3 years younger? Perhaps the reason lies not only in the food itself, but also in the mechanism and principles behind the food matching.
When scientists turn their attention to the molecular level, these specially matched foods with nucleotide molecules may be an important reason.
In 2021, a research published in "Functional Food" showed that daily diet is an important source of the body's intake of "nucleotides (NTs)" molecules. [2] It is explained in this article that nucleotides are the basic substances of life. It is not only an integral part of the basic genetic material nucleic acid, but also participates in the transformation process of many cellular and is regarded as an important nutrient element of living organisms.
nucleotides have various forms in the body, such as adenosine triphosphate (ATP) that transfers chemical energy to physiological processes; important coenzyme factors NAD, Coenzyme A and NADP+; cAMP and cGMP involved in cell signaling; nucleic acid nutrition refers to nucleic acid, nucleotide, nucleic acid derivative and other nucleic acid nutrients. With the continuous progress of scientific research, nucleic acid nutrition is increasingly valued by the academic and industry.
In addition, studies also revealed that nucleotides have a good enhancement effect on immune cells . promotes interleukin-12, interleukin-2 secretion, and interleukin IL-4 secretion, thereby upregulating the proportion of Th1 cells. Th1 cells are involved in antigens and bacterial immunity, and can also assist cytotoxic T cells (CTL) differentiation and activate macrophage .
However, only about 5% of the nucleotides from food sources enter the nucleotide pool in the cell, so an unbalanced diet may cause nucleotide nutrition deficiency. Although Yale's "8 weeks younger than 3 years old" recipe works, it is difficult for everyone to stick to it for a long time, especially for Chinese people who have rich cuisines and "food is the most important thing for people".
study also pointed out that in the process of intestinal damage and aging of , the absorption and utilization of nucleotides decreased, and normal ingestion of nucleotides from food is difficult to meet the needs of cell metabolism. At this time, exogenous supplementation of nucleotides may be helpful for having better immunity and healthier bodies.
related market has exceeded 10 trillion, and nucleotide molecules may promote the arrival of the 100th age
With the revelation of the importance of nucleotides, coupled with the endorsement of the safety of natural substances in the human body, related dietary supplements have also set off a wave in the market, which may help tens of millions of people to enhance their physical fitness .
The well-known investment bank Bank of America Merrill Lynch pointed out in a report: Medical knowledge will double every 73 days, and a technological advancement is sweeping over. Relying on the rich scientific knowledge created by scientists, humans' understanding of themselves is becoming more and more profound, and they can extend their healthy lifespan through efficient methods.
Whether it is Yale's daily dietary exercise or nucleotide supplements, we are working towards a goal - to help humans live better and longer, and now we are getting closer to this goal step by step.
As Professor Linda Graton said, "The age of a hundred is a fact that is happening." It’s time for us to make some preparations, are you ready?
Reference:
[1] https://www.aging-us.com/article/202913/textml3
[2] https://www.sciencedirect.com/science/article/pii/S175646462100147X
[3]Chen Q, Z SIDT1-dependent absorption. Cell Res. 2021;31(3
