Refer to the survey of foreign websites, the most popular winners of are John Jumper, Janusz Pawliszyn and Shankar Balasubramanian. Let’s share their achievements together.
Artificial intelligence prediction of protein 3protein
precisely predicts protein structure, which has always been an important task in the academic community, and it is also an extremely time-consuming and labor-intensive work. Today, with the help of the rapid development of artificial intelligence, we can solve this problem more efficiently.
In 2020, the DeepMind team led by Demis Hassabis and Dr. John Jumper designed the AlphaFold artificial intelligence (AI) system to crack the protein folding problem that has plagued the biology industry for 50 years and can accurately predict its three-dimensional structure based on the amino acid sequence of the protein. In the following six months, DeepMind and the European Institute of Bioinformatics (EMBL-EBI) jointly released a database of protein structures predicted by AlphaFold, covering 350,000 protein structures of humans and 20 commonly used model organisms, and accurately predicted 98.5% of human protein structures. The work of
Demis Hassabis (left) and John Jumper (right)
AlphaFold was rated as the annual scientific breakthrough in 2021 by " Science ". In July this year, AlphaFold had predicted 214 million protein structures for more than one million species, covering almost all known proteins on Earth. AlphaFold shortens the time to determine protein structure from months to years to hours or even minutes, and also helps drug design, nanomaterials, synthetic biology, , and fundamental understanding of cellular processes. It has great prospects and has also changed the way we explore the world.
Solid-phase microextraction technology
Janusz Pawliszyn is an internationally renowned analytical chemist, an academician of the Royal Canadian Academy of Sciences, a chief scientist in analytical chemistry and environmental chemistry , a chief scientist of the Canadian Natural Science and Engineering Technology Research Council, and a founder of solid-phase microextraction (SPME) technology.
Pawliszyn has been committed to the research of advanced sample pretreatment technology for many years and has been applied to the identification of target analytes, in situ analysis and in vivo detection in complex matrices. His research focuses on isolating and identifying samples to be tested by using highly automated integrated analytical instruments when facing complex matrix samples. Dr. Pawliszyn's research team used a variety of separation techniques, including gas phase, liquid phase, and capillary electrophoresis. has published more than 500 papers and monographs, including more than 100 papers in Analytical Chemistry, with an index of H-index of 82. In 2006, it was selected as the chemist with the highest citation of ISI papers. Editor-in-chief of Trends Anal. Chem. and Anal. Chim. Acta, editor-in-chief of J Sep Sci., Journal of Pharmaceutical Analysis, and editorial board members of several magazines.
Janusz Pawliszyn
Second-generation gene sequencing technology
Shankar Balasubramanian is a senior leader of the Cambridge Cancer Institute in the United Kingdom and a researcher at the Trinity College of Cambridge University in , a member of the Royal Society of the United Kingdom and a member of the European Molecular Biology Organization (EMBO).
Shankar Balasubramanian
Balasurabramanian studies high-throughput sequencing technology (NGS), also known as the second-generation gene sequencing technology. It has the advantages of high output and high resolution. It can quickly read sequences. While providing rich genetic information, it can also shorten the sequencing time.
In 1998, Shankar Balasubramanian of the University of Cambridge and other collaborators David Klenerman and Pascal Mayer developed the DNA sequencing method commonly known as Solexa Sequencing . Compared with DNA sequencing techniques based on Sanger method, this technology has overwhelming advantages, such as fast sequencing, automatic sequencing, low-priced, accurate and simple, and multiple DNA strands can be parsed in parallel at the same time. Based on this technology, humans were able to quickly identify and characterize the new coronavirus, thereby rapidly developing vaccines and monitoring new mutant viruses in real time.
High-throughput sequencing technology not only made breakthroughs in academics, but also achieved great success in commercialization. has become the mainstream in the market at present, with a share of 80% . This technology has completely changed biology and also allowed us to quickly sequence genes, accelerating the development of biology and medicine.
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Who will eventually fall into? Pay attention to the popular science of chemistry, let’s wait and see!
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