Youth Daily·Youth Shanghai Reporter Yang Lijia
In 2019, 32-year-old Ye Zhenlong was awarded the honorary title of the 15th Shanghai Youth Job Expert. After three years, recently, he won the honorary title of the 21st National Youth Job Expert. This doctoral student graduated from Oncology from the Second Military Medical University is currently the president of the Beijing Center of Shanghai Cell Therapy Group Co., Ltd., and a master's supervisor at Shanghai University and a distinguished professor at Binzhou Medical College. He has been engaged in oncology immunotherapy and related in vitro diagnosis research and development, with the goal of allowing cells to change the length and abundance of life.
It is really difficult to contact Dr. Ye during this period - he is busy preparing to establish Phase 2 of the Beijing Center of Shanghai Cell Therapy Group Co., Ltd. Shanghai Cell Therapy Group is a high-tech company established on the basis of the municipal engineering technology research center approved by the Shanghai Science and Technology Commission. It is a cell health complex platform company with cell therapy as the core to build a three-in-one closed-loop industrial chain of "cell storage, excellent cell drug research and development and precise cell clinical transformation". What is cancer immune cell therapy? Dr. Ye said that in layman's terms, it is to extract the patient's own immune cells from the body, and genetically transform them in the laboratory, install GPS and amplify and activate them, and then inject them back into the patient's body. The immune cells equipped with GPS can successfully find cancer cells in order to achieve the purpose of killing tumor cells and disintegrating tumor tissue. "Cells are the basic tissue and functional units of the living organism. Cell therapy, a new cutting-edge biomedical technology, is in the breakthrough stage of 0-1. I hope that through the application of innovative cell technology, more people can have a life, healthy, happy and quality life." Dr. Ye introduced.
For many years, Dr. Ye has devoted himself to the professional field, and has published 13 international journal papers as the first author or corresponding author, applied for 30 patents and authorized 8. His team innovatively developed immune cell therapy technology with independent intellectual property rights, and published the first international paper on the treatment of solid tumor immune cell factory in February 2021, which means it is expected to solve the "bottleneck" problems in the two major industries, which are inefficient and expensive in the treatment of solid tumor immune cell. The reporter learned that in response to the problem of the efficacy of solid tumors, Shanghai Cell Therapy Group Co., Ltd. will calculate the nano-antibody with billions of nano-antibody, and use gene sequences to deduce the antibody structure, immunogenicity, affinity, specificity and functionality, and comprehensively upgrade the antibody from the third-generation technology to the new fourth-generation antibody technology with genetic big data and artificial intelligence as the core, and research a series of outstanding CAR-T GPS navigation products and products that change the microenvironment. In response to the high-cost problem, through independent innovations in a series of underlying technologies such as transposonases, tinipasmid, delivery vectors, mRNA, etc., we will develop a non-viral transgenic technology with complete intellectual property rights and excellent. Through continuous optimization of the cell production process, the cell production time is greatly shortened, from the original 14 days to 5 days. In the end, it is expected to complete production in just a few hours, and even realize in vivo CAR-T preparation, reducing costs by more than 90%, and truly realizing cost reduction and efficiency improvement in the cell industry.
During this year's epidemic, the group's subsidiary Shanghai Mengchao Cancer Hospital completed nearly 800,000 nucleic acid samples, quickly prepared nucleic acid testing capabilities and qualifications, supported normal nucleic acid sampling, and undertake nucleic acid sampling points in Anting Town and Waigang Town, Jiading District. While increasing the treatment of tumor patients, epidemic prevention, community dispensing, patient treatment and other work will be carried out simultaneously.
To this day, Dr. Ye has completed a gorgeous turn from a medical science and technology talent to a corporate management talent, and is practicing how to lead the team to the top while continuing to pursue excellence in professional fields. In the future, for Dr. Ye, the young president, there will be infinite space for galloping.
Youth Daily: In addition to the most cutting-edge technology, we have spared no effort in popular science. What considerations are this?
Ye Zhenlong: Most people have a low scientific understanding of cancer, and believe that having cancer is equivalent to dying.Many real cases of failure in anti-cancer have allowed most of us to adopt negative thinking methods and avoid and confrontational behaviors after getting cancer, which invisibly aggravates the resistance to cancer treatment under negative thinking and negative behavior. We hope that through popular science, more people can scientifically understand cancer and scientifically choose methods to treat cancer. In addition, it is also very important to increase everyone's awareness of immune cell storage and early cancer screening. Especially for families with cancer inheritance, it is necessary to conduct cancer genetic risk assessment. Through genetic testing technology, genes related to drug sensitivity, tumor susceptibility, high incidence, genetic diseases, and nutritional absorption and metabolism are analyzed, so as to evaluate the risk of tumors, high incidence and other diseases of the subject, prevent diseases, guide precise medication, scientific diet, and healthy life.
Youth Daily: Do you have any vision for the 2nd issue and for the future?
Ye Zhenlong: hopes that the group can become the world's largest comprehensive cancer prevention and treatment center integrating antibody research and development, cell production, cell frozen storage and cell treatment. For this goal, the group also pays special attention to the scientific research innovation and transformation of young professional and technical talents, attaches great importance to the construction of talent teams, actively builds a science and technology innovation platform, continuously increases investment in science and technology, and strives to create an environment conducive to the cultivation of young professional and technical talents and stand out.
Youth Daily·Youth Shanghai Reporter Yang Lijia
Editor: Zhang Hongye
