Recently, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences The team of Academician Chen Hualan has made important progress in the research of H5N1 subtype highly pathogenic avian influenza virus. This research has systematically clarified the origin and evolution of the H5N1 avian influenza virus currently raging around the world. and space-time transmission, and conducted a systematic biological study on the H5N1 virus detected in my country. Relevant research results were published in "Emerging microbes infections".
This study found that the currently circulating H5N1 virus was produced in the Netherlands in October 2020. It is a reassortment of H5N8 avian influenza virus and H1N1 and H3N8 subtypes of avian influenza viruses. From October 2020 to August 2021, the new H5N1 virus was prevalent in poultry and wild birds in many countries in Western Europe, Northern Europe, and Eastern Europe, and spread to many African countries. Starting in September 2021, it caused a major outbreak of avian influenza in Europe and spread to many countries in Asia and North America. Since January 2020, H5N8 and H5N1 viruses have caused the death or culling of more than 200 million poultry birds around the world. Due to the widespread use of avian influenza vaccines, these new H5 viruses have not caused substantial harm to my country's poultry.
The National Avian Influenza Reference Laboratory collected 26,767 wild bird and poultry samples nationwide from September 2021 to March 2022, from which 13 strains of H5N1 virus were isolated. In order to explore the origin of these newly introduced H5N1 viruses into my country, researchers conducted a systematic genetic evolution and spatiotemporal transmission analysis on 233 representative strains of H5N1 subtypes around the world. It was found that since the H5N1 virus currently circulating in the world first appeared in the Netherlands in October 2020, it has undergone complex gene segment reassortment with a variety of wild bird-derived avian influenza viruses in nature, forming 16 different genotypes (G1- G16). Four genotypes have been monitored in my country, namely G1, G7, G9 and G10. Among them, G1 and G10 were introduced into our country from Europe in November 2021 and January 2022 respectively. G7 was introduced into our country from South Korea or Japan in November 2021. The source of G9 is unclear. The antigenic analysis of
shows that the H5-Re14 vaccine strain currently used in my country has a good antigenic match with it, proving that the H5 and H7 trivalent avian influenza inactivated vaccines can effectively block the invasion of such H5N1 viruses into immunized poultry. In view of the wide distribution of this type of H5N1 virus in wild birds around the world, the article calls on high-risk countries to immunize poultry with the H5 subtype avian influenza vaccine to effectively block the spread of the virus from wild birds into poultry, thereby effectively reducing its impact on human health. threaten.
It is understood that the research was funded by the National Natural Science Foundation, National Key Research and Development Program , Chinese Academy of Agricultural Sciences Science and Technology Innovation Project and other projects.
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Source: Guangming.com—Science Popularization in China
