https://www.science.org/doi/10.1126/science.abm1741 Researchers such as Zhuang Xiaowei from Harvard University used the MERFISH technology (1) developed by them to analyze the cell composition, distribution pattern and interaction of the human cerebral cortex, and further compare

2024/05/1509:40:32 science 1142

https://www.science.org/doi/10.1126/science.abm1741

Harvard University Zhuang Xiaowei and other researchers used the MERFISH technology (1) developed by them to analyze the cell composition, distribution pattern and interaction of the human cerebral cortex, And further compared the differences in tissue structure with the corresponding positions of mice (2).

researchers combined previously published brain single-cell sequencing data (3), selected a total of 4,000 genes with high information content, differential expression, and some other suitable markers for labeling, and analyzed more than 100 types of cell groups. The researchers further studied the interaction and proximity between different types of cells (cell bodies) in the human and mouse cerebral cortex based on this unique single-cell molecular analysis of information-rich and high spatial resolution data. In relation to , it was found that the interaction between human (compared to mouse) cerebral cortex nerve cells and non-nerve cells such as oligodendrocytes and microglia is more obvious; it is speculated that it may be more depleted with the human cerebral cortex Yes, more support is needed regarding (2).

Differences in the interaction between different types of cells in the cerebral cortex of humans and mice (2)

This work was published in Science on June 30; researchers believe that this in-depth analysis of the structure of brain cells can help understand their functions Mechanisms and association with neurodegenerative diseases (2).

Comment(s):

Using MERFISH to analyze the interactions between brain cells is indeed very unique; however, nerve cells still rely more on the connection network mediated by axons and dendrites to function. If this information can be further analyzed simultaneously, Gain a deeper understanding of the organizational structure of the cerebral cortex.

In addition, the specific functional impact of the structural characteristics of the human cerebral cortex is also a question that needs further answers.

Corresponding author introduction:

http://zhuang.harvard.edu/

References:

1. K. H. Chen, A. N. Boettiger, J. R. Moffitt, S. Wang, X. Zhuang, Spatially resolved, highly multiplexed RNA profiling in single cells .Science (80-. ). 348 (2015), doi:10.1126/SCIENCE.AAA6090/SUPPL_FILE/CHEN-SM.PDF.

2. R. Fang et al., Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH . Science (80-. ). 377, 56–62 (2022).

3. R. D. Hodge et al., Conserved cell types with divergent features in human versus mouse cortex. Nature.573, 61–68 (2019).

Original text Link:

https://www.science.org/doi/10.1126/science.abm1741

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