Spatiotemporal correlation between macrophages and exhausted CD8+ T cells in tumors Matthew F., University of California, San Francisco, USA.

2024/05/1422:33:32 science 1663

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in

tumors

Matthew F. Krummel of the University of California, San Francisco published a paper titled Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in Cancer Cell. Research papers on cancer. They dissected the molecular mechanism of immune codifferentiation in which TAMs and exhausted CD8+ T cells (Tex) maintain each other's maturation and presence in the TME through long-term antigen-specific synaptic contacts. This study reveals a mechanistic link through a positive feedback loop driven by the antigen and provides a possible pathway by which T cells, , and TAMs similarly contribute to initial and sustained tumor immune evasion.

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