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eats fat-rich foods, and life experience tells us , Especially fat belly. Pot belly is not only an image problem, but also a health problem. Many studies have found that has too much fat, and the visceral fat tissue accumulated in the abdomen is more harmful than fat in other parts of the body, which is closely related to the increase in the incidence of metabolic diseases such as type 2 diabetes .
Image source: 123RF
Published in a research paper on Nature Metabolism, a sub-journal of " Nature", researchers at Monash University, Australia (Monash University) found that a high-fat diet The cause of abdominal fat accumulation and insulin resistance problem, intestinal lymphatic dysfunction is an important underlying cause unknown in the past.
This study also pointed out that uses lymph-targeting drugs to repair mesenteric lymphatic vessels, which can reverse the weight gain and insulin resistance caused by a high-fat diet .
After feeding experimental mice a high-fat diet, the researchers found that the mesenteric lymphatic vessels wrapped in visceral adipose tissue are stimulated and grow.Form many disorderly branches. Along these tortuous lymphatic vessels, the lymph fluid becomes easier to penetrate into the visceral fat tissue. And because these lymph fluids are rich in lipid metabolites and various pro-inflammatory factors produced after digesting fat in the intestines, their influence on adipose tissue promotes insulin resistance.
"The fat accumulated in the abdomen is more closely related to metabolic diseases such as diabetes than fats in other parts. In this study, first discovered the biological reason to explain this phenomenon "The corresponding author of the study, Professor Natalie Trevaskis, pointed out, "We have shown that a high-fat diet can cause mesenteric lymphatic dysfunction, which in turn promotes more fat deposition around the abdomen and promotes insulin resistance."
The researchers then used clinical samples. Validation shows that the destructive cycle observed in mouse experiments also occurs in humans.
Image source: 123RF
In this study, the scientists further showed that inhibits pathways related to lymphatic dysfunction and interferes with this cycle, which may be a potential treatment for obesity and related metabolic diseases Method .
In order to help the intestinal lymphatic system restore function, this research team cooperated with the clinical stage biotechnology company PureTech Health to try to use Glyph, a proprietary technology platform developed by the company, to deliver oral small molecule drugs. Into the lymphatic system.
Because mesenteric lymphatic dysfunction is regulated by cyclooxygenase (COX)-2 signaling, the researchers used lymphatic targeting technology to directly deliver COX-2 inhibitors into the mesenteric lymphatic vessels and lymph nodes to help obese mice regain Build the structure of lymphatic vessels.
experimental results show that mice that are obese due to a high-fat diet,After this treatment, the weight was significantly reduced and insulin resistance improved significantly.
researchers concluded that these exciting preclinical experimental results show that targeting obesity-related mesenteric lymphatic dysfunction represents a potential treatment option for the treatment of metabolic diseases. We look forward to the follow-up progress of these new therapies to save obese people from eating fat belly as soon as possible.
Reference:
[1] Enyuan Cao et al, Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity, Nature Metabolism (2021). DOI: 10.1038/s42255-021-00457-w
[2] World first: Monash University researchers identify potential cause and treatment for obesity and insulin resistance. Retrieved Sep. 24, from https://www.monash.edu/news/articles/world-first-monash-university-researchers- identify-potential-cause-and-treatment-for-obesity-and-insulin-resistance
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