In recent years, immunotherapy has shined in the oncology industry, and multiple treatment methods and drugs go hand in hand to bring new options and hopes for the treatment of cancer patients. Scientists are fighting in full swing on the immune battle against cancer, so how did this battle start? What exactly is immunotherapy? What is its relationship with tumor treatment?
Welcome to the first issue of "The Battle of Immunity"-what is immunotherapy
's progress in science and technology In the insurmountable mountains, the traditional Three Musketeers—surgery, chemotherapy, and radiotherapy—obviously can no longer meet people's expectations for tumor treatment. Therefore, scientists have fought the battle against cancer in different battlefields. Among them, the immune battle has become a rising star in the melee. Although it is a "new star" but not young, where do you start? You then look down.
As early as the late 1890s, Dr. William B. Coley discovered that cancer patients infected with certain bacteria sometimes caused tumor regression or even complete remission.
This is called The first immunotherapy tried in the world ,The first shot of the battle of immunity was launched, but at the time, this therapy was not accepted by the medical profession. As soon as immunotherapy was first introduced, it encountered the cold reception of the world and fell silent in the dust.
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Nowadays, BCG vaccine for the treatment of bladder cancer has been widely used clinically and has shown excellent therapeutic effects, effectively reducing the recurrence rate of bladder cancer and delaying the progression of the disease.
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Atelizumab became the first FDA-approved immunotherapy drug for breast cancer, and it showed surprising results once it debuted.
The results of the triple-negative breast cancer patients with positive PD-L1 expression showed that the overall survival of atilizumab patients was prolonged by 7 strong22 Month ! Since then, breast cancer immunotherapy research has kicked off, with unprecedented pomp.
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Several beautiful victories in immunotherapy were in full swing.
So, what is such a hot immunotherapy?
Push away the fog and reappear the power of immunity
span1 is the most wonderful creature in nature.And immune system is the most wonderful guarding army in our body. When foreign "invaders" such as bacteria and viruses appear in the body, our escort army immediately assembles soldiers and horses to annihilate them.
Not only that, but also for the "mutated" dangerous molecules in our body, such as cancer cells, the immune army will also launch an attack to maintain the peace of the body.
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0 span Adult normal cells evade attack , and will also cause suppression to our immune system.
This resulted in the immune army’s heavy punches not knowing where to hit, and the army’s offensive capabilities were gradually weakened. Eventually our defense function is low, cancer cells aggressively attack the human body,Expansion of territory.
Seeing that the immune army retreats steadily, it will be wiped out. At this time, immunotherapy appeared! They tear off the camouflage of cancer cells (for example: inhibit PD-L1— PD-1 signal transduction that is active due to the wrong signal sent by cancer cells, and the immune system eliminates cancer cells if the PD-L1—PD-1 signal is active Suppressed) , exposing the specific antigens on them, so that the immune army can clear the fog, recognize the true face of cancer cells, and achieve precise strikes.
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span1 immune system can also improve the immunity of the army span_span1 Military T cells are specially modified and then fed back into the body) , all of them are worthy of one hundred, brave and martial, and the cancer cells are beaten and never dare to come out again!
It turns out that we have a magical army that can destroy cancer cells in our body. Not only can we destroy cancer cells _span 25strong span1 _span 25strong And basically won’t injure ’s normal cells in the body, and won’t be left wailing all over after a melee. Compared with chemotherapy, which kills the enemy by killing one thousand and self-destructing 800, it makes people love and hate. Immunotherapy is really an outstanding model for cancer treatment!
How did immunotherapy go from being uninterested to being popular in the tumor world?
The next issue of Popular Science will bring you the "history of fame" in immunotherapy.
Editor: breast cancer Mutual Jun
Cover Source: photo map network
Reference Source:
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