Recently, 's latest research achievement "Drug Preconcentration and Direct Quantification in Biofluids Using 3D-Printed Paper Cartridge" by Bio-optics team of School of Life Science and Technology, Xidian University, was published by Biosensors and Bioelectronics, a top academic journal in the field of international biosensors . The journal is the top journal in the field of biochemical analysis and sensors, with an impact factor of 10.257 and a CiteScore of 17.60 in 2020, ranking first among similar SCI academic journals in the world for a long time.
The detection of drugs in body fluids, especially the anticancer drug , is of great significance for improving the treatment efficiency of drugs and developing new tools for clinical diagnosis and treatment. However, the traditional detection technology requires multi-step operations, and has disadvantages such as complex process, long time-consuming and high cost, which greatly limits the development of drug detection in clinical diagnosis.
In response to the above problems, innovatively developed a portable test paper box for the detection of anticancer drugs in body fluids. The test paper box includes a paper-pointed surface Enhanced Raman Scattering (SERS) substrate and 3D printed detection box, through systematic research on the design parameters of the test paper box and its pre-concentration effect and quantitative detection performance in body fluid samples, it is found that the test paper box will have a pre-concentration ability. increased by 18.13 times , compared with the non-pre-concentration method, the SERS performance increased by 9.93 times , and then realized the anticancer drugs epirubicin hydrochloride, cyclophosphamide and Rapid preconcentration and direct quantitative detection of their mixtures.
It is worth mentioning that the test paper box adopts an integrated detection process, detection time is shortened from 1 day to 1 hour , including sample pretreatment and pre-concentration, drying , SERS measurement and quantitative analysis, but However, the cost is at least 50 times lower than that of common detection kits in the market, and it is expected to become a point-of-care detection tool for drug pre-concentration and quantification in clinical diagnosis.
In recent years, under the care and support of Dean Tian Jie and Secretary Wang Liling of the School of Life Science and Technology, Xidian University, and under the leadership of Professor Hu Bo, the bio-optics team has been oriented towards people's life and health, and followed the team of Onward and Upward. Spirit, we have overcome difficulties and perseverance in our scientific research work, and have also achieved important research results in the design and development of 3D printed microfluidic chips and portable Raman detection devices and their applications in our biomedical diagnosis and treatment. The thesis Published in top international academic journals such as Sensors and Actuators B: Chemical (impact factor: 7.1), Lab on a chip (impact factor: 6.774), Analytical Chemistry (impact factor: 6.785).
Thesis information:
Graduate student Cheng He and doctoral student Yi Langlang are the co-first authors of the paper, young teacher Zhao Lei is the co-corresponding author, He Cheng, # Langlang Yi, # Jianduo Wu, Guoqian Li, Gang Zhao, Zhixiang Xiao, Bo Hu,* Lei Zhao,* Jie Tian,* Drug Preconcentration and Direct Quantification in Biofluids Using 3D-Printed Paper Cartridge, Biosensors and Bioelectronics, 2021, 189, 113266.
Extended reading :
Life Science, Xidian University Based on the strong electronic information discipline of School, the of the School of Technology focuses on the interdisciplinary field of deep integration of biomedicine and electronic information, and conducts in-depth research in the fields of molecular imaging, neuroimaging , and biomedical big data.The biomedical engineering major established in 1990 is one of the first batch of master's programs approved for trial operation in the country; in 1996, the biomedical engineering department was established, which is affiliated to the school of electronic engineering, and began to cultivate biomedical engineering undergraduates. In 2006, the school established the Life Science Research Center with Professor Tian Jie, a distinguished professor of Changjiang Scholars, winner of the Outstanding Youth Fund, and "973" chief scientist, as the academic leader. In order to promote the healthy development of biomedical engineering, the School of Life Science and Technology was established in 2009 on the basis of the Department of Biomedical Engineering and the Life Science Research Center. The
college has a complete system for training undergraduate, master, and doctoral talents, and has "biomedical engineering", " biotechnology " and " intelligent medical engineering " undergraduate majors, of which "biomedical engineering" was selected. National first-class undergraduate professional construction site ; has "biomedical engineering" master's degree authorization point and "bioinformatics science and technology" doctoral degree authorization point.
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Source:
of Xidian University
