Helicobacter pylori: How powerful is the primary carcinogen that infects 800 million Chinese people?

01

66-year-old Liu is healthy on weekdays, with normal physical examination indicators and normal tumor markers. Only Helicobacter pylori is positive. Since there is no discomfort, he is not concerned.

But what I did not expect is that in an occasional gastroscopy, it was discovered that advanced gastric cancer ! Fortunately, it was discovered in time. After gastrectomy, Lao Liu is now recovering well.

02

Ms. Liu, 33 years old, gave birth to her second child last year. Ms. Liu has always suffered from indigestion and constipation, but she didn't care about it. I came to the hospital for inspection only last month. The carbon 14 breath was positive +++. The gastroscope found suspicious lesions on the anterior wall of the gastric body. The pathological results showed early gastric adenocarcinoma .

After a comprehensive evaluation, the doctor performed endoscopic submucosal dissection for Ms. Liu, and the operation was successful.

While opening up the hearts of the owners of these two stories, the word "Helicobacter pylori" has once again entered our sight, and recently it has also been on the hot search .

my country is a big country with Helicobacter pylori infection, but many people still don't know its performance and treatment methods, which delays treatment. In order to avoid this situation, I will give you a brief science today.

Helicobacter pylori: a Class I carcinogen of gastric cancer

Helicobacter pylori is a very infectious bacterium with a very high incidence in my country. Strong1strong has an overall infection rate of 59 %, about 830 million people , and the infection rate of children is as high as 40%.

After infection with Helicobacter pylori, it can parasitize the gastric mucosa tissue,Strong1strong in turn stimulates and damages the gastric mucosa, causing a variety of gastrointestinal diseases, such as chronic gastritis , peptic ulcer, duodenal ulcer, lymphoma of the lymphoid tissue associated with the gastric mucosa, gastric cancer, etc. Strong1strong has been recognized by the world health The tissue is classified as a Class I carcinogen of gastric cancer.

As for the relationship between gastric cancer and Helicobacter pylori, everyone is also very concerned about it. Current studies believe that there is a certain correlation between the two.

The epidemiological survey in China shows that Helicobacter pylori positive has a high detection rate in areas where the incidence of gastric cancer is also high . However, being positive for Helicobacter pylori does not mean that you will get gastric cancer in the future. Strong1strong Helicobacter pylori positive is just one of the causes of gastric cancer. Factors such as genetics, poor diet, environmental pollution and viral infections are also crucial.

Therefore, we should not be overly panic about Helicobacter pylori, and we should not be careless, pay more attention to it, find suspicious symptoms, and seek medical treatment in time.

What are the symptoms of Helicobacter pylori infection?

After infection with Helicobacter pylori, the body will have a series of symptoms, the following are more typical:

① Loss of appetite, bloating : Mainly caused by local bacteria invasion, the stomach function is impaired, and the digestion speed is slow and unable to Absorption of nutrients, which in turn causes decreased appetite, loss of appetite, and bloating.

②Stomach pain : Helicobacter pylori stimulates the gastric mucosa for a long time, causing inflammation of the stomach and causing pain.

③Acid reflux heartburn : During the parasitic process of the bacteria in the stomach,Affected stomach function, resulting in increased gastric acid secretion, which in turn causes symptoms such as acid reflux and heartburn.

④Halitosis : About 80% of Helicobacter pylori infected people will have halitosis , mainly due to the decline of gastric function and the inability to completely digest the taste of food, so that the "clear breath" cannot rise. "Muddy gas" cannot be caused by falling.

There are also a small number of patients who are infected with Helicobacter pylori and will not show any obvious symptoms. At this time, you must cooperate with professional examinations.

urea [13C/14C] breath test , which can accurately reflect whether the body is infected with Helicobacter pylori, has the characteristics of convenience, high accuracy, and no pain. It is currently one of the ideal detection methods. It is also possible to take biopsy through a endoscopy for detection, which can directly check the overall condition of the gastric mucosa, such as whether there are ulcers, atrophy, polyps, tumors, etc.

You can choose the appropriate examination method under the guidance of your doctor according to your specific situation.

is positive, do I have to eradicate it?

For the eradication of Helicobacter pylori, the standard triple therapy (PPI+2 antibacterial drugs) was used to cure Helicobacter pylori, but the eradication rate of standard triple therapy has been lower than 80% due to the increase in resistance to antibiotics , so 's current preferred method is quadruple therapy , which adds bismuth on the basis of triple therapy.However, because each person's specific situation is different, the specific matching needs to be different from person to person.

needs to remind everyone: Not everyone needs to eradicate Helicobacter pylori .

Helicobacter pylori is one of the pathogenic bacteria, theoretically it should be eradicated in time, but Professor Chen Minhu, deputy dean of the First Affiliated Hospital of Sun Yat-Sen University, believes, "China's Helicobacter pylori infection The population base of is very large, more than half of the population is positive, which means that it is unrealistic to actively screen and treat all Helicobacter pylori positive patients. Not only is the cost too high, may also cause antibiotic resistance problems, More serious consequences."

The specific need for eradication depends on the patient’s specific conditions, such as medical history, symptoms, etc.

Generally, the following people need to eradicate Helicobacter pylori in time:

You can compare it. If you meet the conditions, it is recommended to go to the hospital for diagnosis and treatment in time. If you do not meet the above indications, close observation Just take precautions.

How to prevent Helicobacter pylori infection?

Helicobacter pylori is mainly transmitted through mouth-to-mouth, feces-to-mouth, etc., so if you want to prevent it, you can usually pay attention to these aspects:

• Do a good job of hygiene , wash your hands frequently, especially before eating After going to the toilet. Do not care about oral hygiene. Brush your teeth sooner or later. It is best to change your toothbrush every 3 months.
• Disinfect tableware and kitchenware regularly It is best to implement a split meal system when eating, try to avoid picking up dishes, especially to avoid mouth-to-mouth feeding to children.
• If you are eating out , it is best to choose a good dining environment with a sanitary environment and bring your own tableware to reduce the chance of infection.

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Reference materials:

[1] Li Yumeng, Ma Jun, Duan Fangling. ACG Clinical Guidelines: Treatment of Helicobacter Pylori Infection [J] . Journal of Gastroenterology and Hepatology, 2017, 26(006):601-624.

[2] Can I check Helicobacter pylori? How is inflammatory bowel disease treated? Listen to what the chairman of the Society of Gastroenterology has to say. Zhongyii Health. 2020-10-23

[3] How much is Helicobacter pylori and gastric cancer related? .Yangcheng Evening News .2015-03-24

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