For ordinary people, metformin is not very familiar. But for diabetic patients, metformin is a legendary drug and the drug of choice for controlling blood sugar, especially suitable for obese patients with type 2 diabetes. Metformin can be used alone or in combination. It not only has a good blood sugar lowering effect, but also prevents hypoglycemia, suppresses appetite, and is beneficial to weight control. It can also improve blood lipid metabolism problems, effectively prevent cardiovascular diseases, and has few toxic and side effects. The latest research found that metformin also plays a certain role in new coronavirus , and can also reduce the risk of severe new coronavirus.
Researchers at the University of Minnesota published a paper in the top international medical journal "New England Journal of Medicine" h on August 18, 2022. A clinical research paper titled "A randomized trial of metformin, ivermectin, and fluvoxamine in the treatment of Covid-19" was published on tml1 (NEJM, IF=176.079). Study results found that metformin may have a benefit in preventing the more severe component of the primary endpoint of Covid-19 (emergency department visits, hospitalization or death).
Although the study observed negative results for the primary endpoint, it is worth mentioning that in the analysis of pre-specified secondary endpoints, metformin was able to reduce the risk of emergency department, hospitalization or death due to COVID-19 by more than 40%. If metformin is used in the early stages of COVID-19 symptoms, the above risk can be reduced by 50%. and treatment with ivermectin or low-dose fluvoxamine had no positive effect.
In fact, there are currently many metformin drugs. In terms of preparations, they are divided into single preparations and compound preparations. Single preparations have different dosage forms.
single preparations include metformin ordinary tablets, metformin enteric-coated tablets, metformin sustained-release tablets, metformin powder, etc. Different dosage forms of metformin have different dissolution and release modes of the drug in the preparation after administration. Ordinary tablets disintegrate and release in the stomach; enteric-coated tablets and capsules disintegrate and release in the intestines; sustained-release tablets and sustained-release capsules slowly dissolve and release in the gastrointestinal tract. Different dosage forms of metformin have different gastrointestinal tolerances. Metformin has common gastrointestinal adverse reactions, such as nausea, vomiting, diarrhea, bloating, indigestion, abdominal discomfort, etc. Compared with ordinary metformin tablets, sustained-release tablets/capsules can reduce gastrointestinal reactions after administration, have better gastrointestinal tolerance, and can improve medication compliance. However, sustained-release tablets should not be broken into pieces to take , otherwise the shell will be damaged and its sustained-release function will be completely destroyed. In fact, it will become an ordinary tablet without a sustained-release function, and it will cause a sudden release of a large dose of the drug, causing safety issues.
compound preparations include metformin glibenclamide, metformin glipizide, saxagliptin metformin, metformin vildagliptin, linagliptin metformin, etc.
Pictures come from the Internet
Metformin and glyburide are suitable for patients who cannot achieve satisfactory blood sugar levels with either metformin or glyburide alone. Since metformin glyburide is more prone to hypoglycemia than metformin, the initial dose should not exceed the daily dose of glyburide or metformin previously taken.
However, whether it is a single preparation or a compound preparation, it has a significant effect on reducing the severity of COVID-19!
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