This winter, I have a fever and feel a little cold. Fortunately, mutual aid and relief were launched, and the difficulty in obtaining antipyretic drugs began to be alleviated. All this should not have happened. After all, more than 30% of the production capacity of commonly used antipyretic drugs and finished drugs on this planet is here. There are more than 500 relevant batch numbers of ibuprofen . Using all the production capacity, hundreds of millions of tablets can be produced every day. Can the embarrassment of relying on medicine to reduce fever and grabbing medicine to take it be overcome? How to take the right path to health? Let’s borrow the latest scientific research conclusions to help you clear up your doubts.
A few days ago, I saw a girl posting a message saying that she had had a fever for three days. After taking medicine, the fever had not gone away and her body temperature was already 34.2 degrees. There is a group of people below who offer advice. Some people say that you should take cold capsules first and then drink hot water. Some people suggest that you should take ibuprofen first and then cover yourself with a quilt to sweat. Look carefully at the picture. Alas, girl, your thermometer looks like it is specially used for factory assembly lines? Does your family run a factory? Was your physical hygiene class given by the coach of the track and field team? Or are you really confused? This thing seems a bit funny, but to be honest, doctors may not always be able to tell the whole truth about body temperature and fever.
We humans are getting colder, so we are prone to fever and difficult to reduce it. Body temperature has become a physiological indicator since 1851. At that time, a German doctor repeatedly measured the body temperature of more than 25,000 people millions of times, added one piece, calculated the average, and got the answer. The fluctuation range of normal body temperature is 36.2 degrees Celsius to 37.5 degrees Celsius, and the average body temperature is 37 degrees. Then, the medical community stipulated that if the temperature exceeds 37 degrees, it is considered a fever. Until 1992, when American scholars were doing research on the vaccine , they had nothing to do and measured the temperatures of the people participating in the trial. They found that the average body temperature was 36.8 degrees. In 2017, British scholars measured 35,000 people and calculated that the average body temperature was also 36.8 degrees. In 2020, Stanford scholars analyzed more than 500,000 pieces of medical information and found that the average body temperature of women dropped by 0.32 degrees and that of men dropped by 0.59 degrees.
As the standard of living and medical care improves, why do humans become cooler? In November 2021, scholars from and Harvard University gave the latest explanation. Research shows that for every 1 degree increase in body temperature, the resting metabolic rate will increase by 10%, and muscles are the largest heat-producing organs. As people's physical activity decreases, the body's heat production decreases. Moreover, many people stay in air-conditioned environments all year round, which weakens the temperature regulation center of hypothalamus in response to stimulation. As a result, humans are generally getting cooler. Using a statistical model, it was estimated that men's resting metabolic rate has dropped by an average of 6% since 1920, which is equivalent to a 75-kg man losing 27 minutes of brisk walking or jogging per day.
Our human immune system requires the participation of a variety of enzymes in the process of fighting pathogens or repairing our own cells , and the activity of enzymes requires appropriate temperature conditions, most of which exceed 37 degrees. A moderate increase in body temperature can activate more immune cells and their responses. If the resting metabolic rate drops by 12%, immune activity will drop by 30%. The decline of one's own immunity brings about the consequences of having a fever when you are sick, and a fever is a high fever. When you have a fever, you take medicines indiscriminately, and the quality of the medicines is uneven, which leads to the tragedy that the magic medicine cannot reduce the fever and damages the liver and kidneys.
Fever can actually heal itself. What needs to be strictly guarded against is persistent high fever and febrile convulsions. A few days ago, on December 23, 2022, the Nagoya University team published a paper in the "Progress" volume of the "Science" series, finally revealing the detailed mechanism of body temperature regulation. Research shows that body temperature regulation is a basic physiological function of homeostasis in mammals. The balance between internal heat production and heat dissipation to the outside world can be adjusted autonomously to maintain core temperature within a controllable range. A body temperature of 34.2 is too cold to be connected to the Internet, and the highest scale of thermometer is 42 degrees. Humans will not burn to the temperature of their own shabu-shabu or barbecue grill.
research has found that central nervous system can control autonomous heat regulation. The key links are sympathetic heat production in brown adipose tissue and other factors, as well as heat loss due to cutaneous vascular activity. The regulatory process is mainly realized by the temperature control center in the preoptic area of the hypothalamus sending out sympathetic excitatory signals. Neurons expressing prostaglandin E3 receptors are a two-way controller that can be activated in high temperature environments and inhibited by the heat source medium prostaglandin E2. At room temperature, neurons can reduce body temperature by enhancing heat dissipation under chemical stimulation. If neurons are inhibited, it will cause brown fat to generate heat. In these refined regulatory processes, γ-aminobutyric acid GABA is the basic determinant for transmitting signals and maintaining thermal homeostasis.
Previously, we have introduced the content of intestinal flora balance and immune function . Now let’s review the key points. γ-Aminobutyric acid GABA is an important inhibitory neurotransmitter in the central nervous system of mammals. More than 40% of synapses rely on GABA to transmit signals, and there are bacteria in the intestine that live on GABA. Therefore, after the intestinal microecology is disturbed, GABA levels may decrease, and physiological activities such as immune function and temperature regulation will be affected. The so-called weak body is actually a weak intestine. Improper diet, disordered lifestyle, and reduced physical activity will lead to imbalance of intestinal flora, decreased immunity, and increased risk of various diseases and cancers. Moreover, diseases come and go like silkworms, making it easy to have fever and high fever, and it becomes more difficult to reduce fever. Therefore, maintaining the balance of intestinal flora and enhancing the level of immune can enhance one's own body temperature regulation ability.
Finally, we have some suggestions for the current dilemma. If you have Yang, it is too late to regulate your immunity. The fever is uncomfortable. How to choose medicine? A few days ago, we said that you will definitely have a fever while you are alive. It has also been said that the ancestor of antipyretics comes from willow bark . No more repetition, everyone can find and review according to their interests. The current chaos in antipyretics is worrying. After carefully reading the instructions for dozens of compound cold medicines, I found that the added amounts of , acetaminophen, and differed by more than 50 times. There are two conclusions. Please remember them and convey them to those who deserve your care. First, if the instructions do not indicate the content of acetaminophen, try to discard it. Second, if you feel that the fever-reducing effect is better, the dosage of acetaminophen may be the highest, so you must be vigilant.
Acetaminophen is the most widely used antipyretic and analgesic. Compound cold medicines are basically added with acetaminophen, or have acetaminophen as the main active ingredient. Most of these ingredients will be metabolized in the liver and combined with glucuronic acid and sulfuric acid. This metabolic process requires enzyme catalysis. When the metabolic enzymes are saturated, a toxic intermediate, acetobenzoquinone imine, will be produced. This intermediate, under normal circumstances, will combine with glutathione to detoxify. When glutathione is consumed too much, the toxic intermediate will combine with liver and kidney enzymes, protein , leading to necrosis of liver cells and renal tubular cells. Therefore, acetaminophen has an accumulation effect. If you eat too much, it will not be metabolized normally, toxic intermediates will accumulate, and acute liver damage and kidney function damage will come soon. During infection, the liver's synthesis and metabolism tasks are heavy and it is more susceptible to damage.
Therefore, as we have said before, if you want to rely on cold medicine to fight the new crown and new crown at home, taking Chinese medicine mixed with Western medicine may damage the liver and kidneys. Again, we remind you to treat fever and fever reduction scientifically. For adults whose body temperature is below 38.5, physical cooling should be the main method as much as possible, especially for those with poor liver and kidney function. Antipyretics and cold medicines should not be taken unless necessary. If the fever is really uncomfortable, you should strictly control the safe dosage of antipyretics or cold medicines and stop taking them when the fever subsides. After recovery, the whole family should pay close attention to to enhance immunity , which is the right way to get out of the dilemma of relying on medicine to reduce fever.
To whomever you love, spread health to whomever you love.
Your health is my concern. Professionals observe health from a scientific and humanistic perspective, including series such as express reports, details, reminders, explanations, opinions, historical stories, etc. The content is the original work of the author Wei Hongling and his team.All forms of misappropriation and reproduction without permission are prohibited, otherwise we will be prosecuted in accordance with relevant laws.
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