According to epidemiological survey , men in my country will have different degrees of prostate hyperplasia after the age of 35. Many men will experience corresponding symptoms around the age of 50. As they grow older, the incidence rate of prostate hyperplasia will become higher and higher. The incidence rate of 60-year-old men is greater than 50%, and more than 80% can be achieved in men aged 80. Our protagonist today, Lao Li, is also a patient with prostate hyperplasia. Let’s take a look at his experience.
Lao Li is 45 years old this year and is a taxi driver. Although his salary is not high, it can be enough to support the family's life. It is worth being happy that in June this year, his son was admitted to a good key university, and the family's financial demand has also increased, so Lao Li has to spend a few more hours of extra hours of class every day.
Although it is very hard to work overtime, Lao Li is full of energy when he thinks that his son is promising, and he feels like he can't finish his energy every day. Sometimes he even goes to the station to pick up people in the middle of the night. rest time is always not fixed . In addition, Lao Li usually likes to smoke, and he also drinks some wine and eats midnight snacks after get off work. His weight has long reached the level of obesity.
After a few months, Lao Li began to feel a little strange in her body. Since last week, Lao Li found that he had become more and more difficult to urinate, and the urine water flowed out became thinner and thinner, and even needed to hold his breath to be discharged. He urinated more and more frequently at night, and hemorrhoids were also developed, so Lao Li came to the hospital for examination.
After coming to the hospital, the doctor first asked a brief question about Lao Li's basic situation, and then did Rectal digital examination When he found hemorrhoids, prostate volume increased , and the doctor suspected Lao Li's prostate hyperplasia.
Next, Ultrasound Examination found that
Doctor explained to Lao Li that driving a taxi for a long time will cause insufficient blood circulation, prostate hyperplasia and compression of the urethra, which affects urination, prone to bladder stones, and at the same time, increasing abdominal pressure will easily lead to hemorrhoids.
For bladder stones, the doctor made Lao Li a bladder stone gravel, and the crushed fine sand was excreted with the urine; for prostate hyperplasia and hemorrhoids, the doctor prescribed some related drugs and let Lao Li go home.
Before returning home, the doctor told Lao Li to exercise regularly, not to sit for a long time, and maintain good living habits ; after returning home, Lao Li adjusted his living habits and working methods. After half a month of treatment, his symptoms improved and gradually returned to normal physical condition.
After reading Lao Li’s experience, you may have a lot to know about prostate hyperplasia, such as what factors are related to prostate hyperplasia? What signals indicate prostate hyperplasia? When does intervention need to be done? How to treat prostate hyperplasia? etc. Next, let’s talk about prostate hyperplasia, deepen our understanding of it, and prevent it in daily life.
1. What factors are related to prostate hyperplasia?
In order to give everyone a more comprehensive understanding of prostate hyperplasia, first of all, let’s understand what factors are related to prostate hyperplasia. After understanding this knowledge, it can provide a basis for preventing prostate hyperplasia in our daily lives.
Hormone levels in the body are closely related to prostate hyperplasia, among which the most related to are androgens and estrogens .The main source of androgens in the prostate are testes. androgens can be catalyzed by 5-α reductase to convert into dihydrotestosterone , which binds to the corresponding receptor on prostate cells. plays the role of inhibiting cell apoptosis and cell proliferation , causing prostate cell proliferation and apoptosis imbalance, and then leading to prostate hyperplasia .
Estrogen is a prostate fiber matrix stimulator. It can bind to receptors on the surface of stromal cells in the prostate. causes these cells to proliferate, thereby promoting the increase in the size of the prostate . As we age, the serum estrogen ratio of increases with age, prompting further prostate hyperplasia .
So as age increases, changes in sex hormones in the body are a very important reason for prostate hyperplasia, so we can understand the conclusion drawn by epidemiology at the beginning of the article. As we age, the incidence of prostate hyperplasia in men is getting higher and higher.
Lifestyle such as smoking, drinking, lack of exercise, frequent sexual activities, etc. Lifestyles are closely related to prostate hyperplasia.
- ①Smoking
- ②Drinking
Hydding effects on the prostate are divided into different situations. Studies have shown that appropriate drinking of has a protective effect on prostate hyperplasia, but when the amount of alcohol consumed reaches more than 60g/d, drinking becomes a risk factor for prostate hyperplasia.
The reason may be that Adjust drinking alcohol has a certain protective effect on the microvessels of the prostate tissue. When the amount of alcohol is too large, it will cause atherosclerosis of the vascular artery and cause blood vessel blockage . Therefore, we advocate proper drinking and do not over-drinke or alcohol abuse.
- ③ Lack of exercise
Most people who lack exercise are accompanied by the habit of
lack of exercise will cause obesity , long-term obesity will cause prostate movement atherosclerosis , causes hypoxia of the prostate tissue, and then the prostate stromal fibrosis and thickening, the prostate volume increases , and eventually develops into prostate hyperplasia.
- ④ Frequent sexual activity
Prostatic hyperplasia is closely related to sexual activity. Masturbation, sexual intercourse, etc. will cause the prostate to be congested. At the same time, the pressure of the prostate smooth muscle increases. Frequent sexual activity will cause smooth muscle hyperplasia , and the prostate volume will increase, causing prostate hyperplasia.
. Related diseases
When the prostate is infected, it can cause Prostatitis , inflammatory cells such as T, B lymphocytes , etc. will enter the prostate tissue, release reactive oxygen species, prostaglandins, etc., causing prostate cells to proliferate , and thus cause prostate hyperplasia.
High blood pressure Hypertension , will cause spasm of the tiny arteries of the prostate, thickening of the tube wall, resulting in narrowing of the lumen, insufficient blood supply, and disorders of the microcirculation, which in turn causes hypoxia to release reactive oxygen species in the prostate tissue, and eventually lead to prostate cell proliferation and the prostate volume increases. Diabetic patients have similar effects as hypertension . It also damages the small blood vessels of the prostate, which in turn causes ischemia and hypoxia in the prostate tissue, and eventually leads to prostate hyperplasia. These factors above mainly promote prostate cells by affecting the level of sex hormones in the body, or by affecting the blood vessels of prostate tissues, which in turn causes ischemia and hypoxia to release reactive oxygen species to promote cell hyperplasia, and ultimately lead to prostate hyperplasia; it can also promote cell proliferation by promoting smooth muscle hypertrophy or inflammation to produce prostaglandins, which in turn trigger prostate hyperplasia.
We already know the risk factors that cause prostate hyperplasia and the relevant mechanisms behind it. In daily life, we can purposefully prevent these risk factors. Let’s talk about the circumstances under which prostate hyperplasia needs intervention.
2. What signal indicates that prostate hyperplasia needs intervention?
(1) Abnormal urination
In order to better understand the relevant symptoms of prostate hyperplasia, we must first understand the general structure of the prostate. The normal prostate is the same size as a chestnut, and the urethra is passed through in the middle, so prostate hyperplasia mainly affects the diameter of the urethra, and thus affects the excretion of urine.
At the beginning, it was manifested as frequent urination . It is obvious that the number of urination increases at night is caused by stimulation of the relevant nerves after prostate congestion.
As the prostate hyperplasia progresses, the symptoms of frequent urination will become more and more obvious. At the same time, it gradually becomes labor-intensive and difficult urination and difficulty urinating , which is manifested as thinning urine and shorter range. You will always feel that the urine cannot be discharged and the time for urination will be prolonged. If you find these symptoms in your daily life, it is best to go to the hospital for examination as soon as possible and intervene as soon as possible.
(2) Urinary retention
As the prostate hyperplasia develops, urethral will be compressed by the hyperplasia tissue more and more severely. At this time, the obstruction of urine excretion is gradually worsening, and urine will be retention in the bladder.
When the sudden change of external factors , such as excessive drinking, constipation, etc., may cause the prostate to suddenly swollen and completely compress the urethra. At this time, the inability to urinate, and acute urinary retention occurs, which is mainly manifested as urinary intention but inability to discharge urine. A bulge can be seen in the abdomen below the navel, and pain in the lower abdomen will also be felt.
In this case, need to go to emergency for catheterization in time to prevent bladder rupture or hydronephrosis
(3) Bladder stones
At the same time, due to the lack of urine rinsing of urine, is prone to urinary tract infection , which is manifested as frequent urination, urgency, and pain in urination . When these situations occur, it is best to go to the hospital for examination and intervention as soon as possible.
When there are three signals: increased nocturnal urine, urinary rheology, acute urinary retention and bladder stones, especially acute urinary retention, you must go to the hospital for examination as soon as possible and intervene and treat early.So what are the treatments for prostate hyperplasia?
3. How to treat prostate hyperplasia?
Drug treatment mainly controls the progress of the disease, and is mostly used in elderly people who are older than the age and cannot undergo surgery. The drugs are mainly divided into two categories. The first category is the smooth muscle that controls the prostate gland . By inhibiting the contraction of smooth muscle, the resistance of the urethra decreases, and then the urine is easier to excrete. main drugs are terazosin , etc.
Another type is -α reductase inhibitor . By inhibiting this enzyme, prostate cells are prevented and prostate cells are smaller, which is conducive to the excretion of urine. The commonly used drugs for are Finaxiongan , etc.
For patients with severe obstruction, surgical treatment is mostly used. The most commonly used surgical method at present is Transurethral prostatectomy . With the development of technology, now laser resection is also becoming more and more widely used. This surgery has certain pain and complications, such as urinary tract infection.
As we age, the incidence of prostate hyperplasia is getting higher and higher. mainly affects sex hormone levels and various reasons such as hypertension and smoking, causing prostate capillary lesions, causing hypoxia and reactive oxygen species to be released, which promotes prostate cells to proliferate, and thus causes prostate hyperplasia. Like Lao Li at the beginning of the article, long-term sitting, smoking and other bad living habits cause prostate hyperplasia.
When prostate hyperplasia changes in urine flow, acute urinary retention, and bladder stones, intervention should be carried out promptly through medication or surgery. Be sure to keep in mind the risk factors that cause prostate hyperplasia, prevent it in advance, and have a happy life.
References:
[1] Ren Yi, Wang Yao, Zheng Ruwen. Current research status of the causes and pathogenesis of benign prostatic hyperplasia [J]. World Traditional Chinese Medicine, 2018, 13(09):2372-2376.
[2] Renwei Ninth Edition "Surgery" "Benign prostatic hyperplasia".
[3] Zhang Xianghua, et al. "Guidelines for the clinical diagnosis and treatment of benign prostatic hyperplasia." Chinese Journal of Surgery 45.24(2007):1704-1707.
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