When Mr. Wang was taking rosuvastatin, he couldn't buy a dose that suited him, so he asked the doctor if he could break the large dose of pills and eat it. Will taking it this way affect the efficacy of the medicine?

When Mr. Wang was taking rosuvastatin, he couldn't buy a dose that suited him, so he asked the doctor if he could break the large dose of pills and eat it. Will taking it this way affect the efficacy of the medicine?

Doctor explained that ordinary tablets of rosuvastatin can be taken open and will not affect the efficacy of the medicine. However, the tablets may appear sharp after being opened. It is easy to scratch the throat when swallowing the edges and corners. Try to break evenly when breaking the tablets so that the dosage of the two and a half tablets does not differ too much.

1

First of all, let’s understand what are the functions and functions of rosuvastatin?

transport of vastatin has a strong cholesterol-lowering effect, which can reduce LDL cholesterol by 52%, increase high-density lipoprotein cholesterol 2 214%, and can also reduce triglyceride level by 10%. The side effects of quitting vastatin are mainly caused by abnormal liver function, and can also increase the risk of disease. statin drug can also increase diabetes ht Risk of ml2

rosuvastatin can be used to reduce the cholesterol content in the blood, prevent vascular atherosclerosis and stabilize plaques, reduce low-density lipoprotein and cholesterol in the blood, and increase the content of high-density lipoprotein in the blood. During the use of rosuvastatin, it is necessary to combine with low-fat diet , which can also reduce the content of high-density lipoprotein in the blood. The pharmacological effects of rosuvastatin drugs also slow down the production of cholesterol in the body, reduce cholesterol accumulation in the artery wall, inhibit atherosclerosis and stabilize plaques in the blood vessels, avoid the resulting myocardial infarction, cerebral thrombosis and other vascular blocked diseases, many hyperlipidemia, atherosclerosis, and vascular stenosis patients will use this drug for treatment.

When using rosuvastatin, it is necessary to combine a low-fat diet, which can also reduce the blood content of cholesterol and other fat substances in children and adolescents with familial hypercholesterolemia.

. It can inhibit the effect of cholesterol synthesis rate-limiting enzyme HMG Coenzyme A reductase, thereby reducing cholesterol synthesis.

, can upregulate low-density lipoprotein receptor on the cell surface, and accelerate the catalysis and metabolism of serum low-density lipoprotein.

, can inhibit the synthesis of extremely low-density lipoproteins.

2

What are the common statins?

statins are a general term for a class of lipid-lowering drugs. They can be roughly divided into natural compounds and synthetic compounds. Natural compounds include pravastatin, lovastatin, simvastatin , mevastatin, etc. Artificially synthesized compounds include atorvastatin, cerivastatin, rovastatin, fluvastatin , etc. There are five main types of statins in the market, including rosuvastatin, lovastatin , simvastatin, fluvastatin and atorvastatin.

, rosuvastatin: It is often used in the treatment of mixed dyslipidemia and familial hypercholesterolemia.

. Lovastatin: It has the effect of reducing total cholesterol and low-density lipoprotein cholesterol. In the treatment of patients with primary hypercholesterolemia, it can play a role in regulating blood lipids .

. Simvastatin: Hypercholesterolemia can be used to lower blood lipids by simvastatin when the dietary therapy is not effective, or when hypertriglycerideemia is combined with . In addition, this medicine also has certain effects in the treatment of coronary heart disease .

4. Fluvastatin: For patients with primary hypercholesterolemia, this drug can often be used for blood lipid regulation treatment, which can help reduce blood lipid levels. Patients with mixed dyslipidemia can also be used for treatment.

5. Atorvastatin: As a blood lipid regulation drug, in the treatment of hypercholesterolemia, if the non-drug effect is not good, this drug can be used, and it can also be used for the treatment of coronary heart disease.

3

rosuvastatin can be eaten? What should I pay attention to during the medication process?

rosuvastatin can be taken half a tablet. Whether rosuvastatin needs to be taken half a tablet depends on the patient's blood lipid control. If the patient takes one tablet of blood lipid, it will be relatively reduced. Each patient should have a goal to lower blood lipids. For example, in patients with coronary heart disease, if there is no stent or no stent, LDL1.8mmol/l.

If the stent is loosened, the LDL should be at least 1.4mmol/l. Some hypertensive or diabetes patients should have lipid-lowering targets of 2.6mmol/l. If you take a tablet of rosuvastatin, the standard and remote targets can be met. Patients can reduce rosuvastatin to half a tablet and after taking half a tablet, it is recommended to recheck the blood lipid for three months to see if the blood lipids rise again and exceed the target range.

If the limit value exceeds, it means that half of the tablets are not enough to reduce fat, and one tablet is still needed to return. Rosuvastatin, as a statin lipid-lowering drug, can mainly reduce cholesterol and inhibit the effect of cholesterol synthesis rate-limiting enzyme HMG Coenzyme A reductase, thereby reducing cholesterol synthesis.

Secondly, it can upregulate the low-density lipoprotein receptor on the cell surface, accelerate the catabolic of lipoprotein , and also inhibit the synthesis of extremely low-density lipoprotein. The main side effects of rosuvastatin are to be alert to the possibility of liver damage caused by drugs, which are manifested as increased aminotransferase after taking the drug, and may be accompanied by symptoms such as bloating, loss of appetite, and nausea. In the test indicators, the aminotransferase will increase significantly. Secondly, the side effects of taking statins reduce muscles. A few patients will experience muscle pain and fatigue after taking statins. Tests and tests can find that the level of creatine kinase has significantly increased. It is recommended that patients pay attention to a light diet during the medication, avoid spicy and irritating foods, and avoid cigarettes, alcohol, etc.

4

What should I pay attention to during the medication process?

rosuvastatin can be taken in the morning or evening, or at any time. There is no need to pay special attention to this aspect. It should be noted that adverse reactions caused by rosuvastatin, such as abnormal liver function, may occur when using rosuvastatin calcium tablets, including increased liver enzyme transaminase index.

So if you use rosuvastatin for three months and six months, or a year, you should go to the hospital to draw blood regularly to see if liver function is normal, it may also affect creatine kinase. When using rosuvastatin, some people may experience muscle soreness, skeletal muscle pain, etc. for unknown reasons. At this time, common adverse reactions of statins drugs, but it can be judged that this part of the reaction is determined by monitoring the blood creatine kinase.

In addition, some patients may experience neurotoxicity during the process of taking rosuvastatin, such as headaches, and may also cause constipation. This may be because rosuvastatin inhibits the production of blood lipids, including the production of cholesterol LDL. In the feedback caused constipation in the patient, it is said that vastatin may also cause abnormal gastrointestinal reactions such as nausea and vomiting, and you should pay attention to it in normal times.