An elderly friend told Huazi that his hands were shaking severely recently. Are you suffering from Parkinson's disease ? What should I do if I get sick? Huazi said that although most patients with Parkinson's disease have hand tremor (tremor) as the first symptom, not all patients will have hand tremor.
The core characteristic of Parkinson's disease is "slow", especially in elderly patients over 70 years old, the symptoms usually manifest as symptoms such as sluggish movement and stiffness. If you find that you have signs of Parkinson, you must find a doctor to actively treat it and use medication to control the progress of the disease.
1. Parkinson's disease is a "chronic disease"
. Treatment of Parkinson's disease, the first thing to do is to face it. Many people believe that it is impossible to cure after suffering from Parkinson's disease, and will give up on one's own emotions. In fact, with the current medical level, many diseases cannot be cured, but through reasonable treatment, can control most diseases symptoms and obtain the same quality of life as normal people.
Parkinson's disease is genetically predisposed. If parents get sick, the probability of children's incidence will be greatly increased. Parkinson's disease has the phenomenon of "premature genetic appearance", that is, the onset will be advanced by generation, and the symptoms of the disease will also worsen by generation . So once you find that you have a tendency to Parkinson's disease, you must treat it as soon as possible.
2. Be prepared for a long-term war with the disease
The pathogenesis of Parkinson's disease is a degenerative lesion of the nervous system , that is, nerve degeneration in the brain, which reduces the release of neurodopamine transmitters and loses balance with acetylcholine transmitters , resulting in movement disorders, tremors , slow movement, autonomic nerve disorders, sleep disorders, inhibition, anxiety and other symptoms.
Parkinson's disease will gradually worsen over time, and it progresses faster than in the early stages of disease than in the later stages of , so once diagnosed, active treatment should be started immediately, which is the key point in the treatment of Parkinson's disease.
After taking the medication, if the symptoms are relieved, you cannot stop the medication. Because Parkinson cannot cure it at this stage, patients with need to insist on lifelong treatment to ensure the quality of life .
3. The main drug to control Parkinson's disease
The pathogenic mechanism of Parkinson's disease is that the dopamine in the brain is insufficient function, so the medication is mainly used to improve the function of the dopamine nerve.
1, levodopa preparation : levodopa is the main drug for treating Parkinson's disease, but it is easily destroyed in the peripheral area, resulting in a decrease in the amount of drugs entering the central nervous system of . Therefore, compound drugs with levodopa peripheral protective agents are commonly used, such as benserazine levodopa (dopaserazine), carbidopa levodopa and other drugs.
2, non-ergot dopamine receptor agonist : Drugs that can directly activate dopamine receptor , such as pramelol, ropinirole , etc. When the efficacy of levodopa preparations decreases, or the "switching phenomenon" occurs, they can be used in combination with this type of drug.
3, Monoamine oxidase B inhibitor : The degradation of dopamine in the brain is closely related to monoamine oxidase B. You can use rasagilan, selegilan and other drugs to inhibit the activity of monoamine oxidase B and enhance the effect of dopamine in the brain.
4, Adamantamantamine : Adamantamine can resist influenza A virus , can also promote the release of dopamine by neurons in the brain, and can inhibit the reuptake of dopamine by neurological disorders, increase the level of dopamine in the nerve space, and also has an anti-acetylcholine effect in the center, which can be used for the treatment of Parkinson's disease.
5, catechol-o-methyltransferase inhibitor : For example, entocapone can inhibit the peripheral degradation of levodopa. It requires combined use with levodopa preparation, and it is ineffective to use it alone.
To sum up, when treating Parkinson's disease, we must understand that this is a chronic disease that cannot be cured, but insisting on taking medicine for a long time can control symptoms and improve the quality of life. Most patients need to take medicine for life and use combination medicines, and they cannot reduce doses, stop medications or change drugs without authorization.
Reasonable use of drugs under the guidance of a doctor is the prerequisite for ensuring successful treatment. If you have any questions about the medication, please consult your doctor or pharmacist. I am Huazi, pharmacist. Welcome to follow me and share more health knowledge.
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