A friend and Huazi said that he was taking atorvastatin. In order to reduce the adverse reactions of the drug, he took the medication once every other day. Is it okay to do this?
Huazi said that the drug instructions for all statins in clearly state "oral, once a day" . Therefore, taking statins the next day is not a regular way to use them. However, this method is not completely wrong, because some studies have pointed out that some people have poor tolerance to statins. When choosing long-acting statins, taking the next day can reduce the occurrence of adverse reactions.
1. Most people cannot stop using statin
Many people asked Huazi, I heard that statins cannot be stopped after they are used. Is it because the drug is dependent? Huazi said that this is not the case. statins are not dependent on , and there is no withdrawal reaction to when the drug is stopped.
cholesterol in the human body 20%~30% comes from diet, and 70%~80% comes from its own synthesis. So many people do not consume cholesterol at all in their diet, but their blood cholesterol levels will still exceed the standard.
At present, the cause of primary hypercholesterolemia is not clear, so it cannot be cured. It can only be controlled by taking statins for a long-term and regular treatment of . Moreover, statins can not only lower cholesterol, but also stabilize atherosclerotic plaques and reverse plaques, which can prevent the formation of thrombosis.
2. Most statins need to be taken at night
There are now 7 types of statins used in clinical practice, namely simvastatin , lovastatin , pravastatin, fluvastatin , atorvastatin, rosuvastatin and pitvastatin .
human cholesterol is mainly synthesized at night, while simvastatin, lovastatin, pravastatin, and fluvastatin have half-life (1 to 2 hours), so taking medicine before going to bed can produce the best effect . The half-life of pitavastatin is about 11 hours. It is also recommended to take at night. If you need to take other drugs at night, you can also adjust the pitavastatin to other times.
Atorvastatin and rosuvastatin are long-acting statin . The lipid-lowering effect can last for more than 20 hours after taking it once. The time of taking it will not affect the efficacy of the medicine. can be taken at a fixed time every day.
3. Can statins be taken
html the next day? The human cholesterol is synthesized every day. In order to maximize the inhibition of cholesterol, requires statins to maintain a certain blood concentration. Therefore, taking medicine once a day is the most reasonable way to use . Moreover, there are no other drugs that can replace the statins that stabilize and reverse plaques. People at risk of cardiovascular disease should try to maintain statin treatment.However, when statins are used, some people will experience a 3-fold increase in liver aminotransferase (ASL, ALTh) and a 3-fold increase in normal upper limit; and muscle fatigue and pain, and a 5-fold increase in creatine kinase (CK) and a 5-fold increase in normal upper limit, which is called "statin intolerance" . Some people can tolerate small doses of statins called "statin partial intolerance" ; some people cannot tolerate any dose of statins called "statin total intolerance" .
For people with partial intolerance of statins, they can first replace them with other statins, or reduce the dosage and use them in combination with other lipid-lowering drugs (ezemebu, eloyuzumab, etc.).
can also be considered for long-acting statins (atorvastatin, rosuvastatin) and take the next day (once every two days) medication method, which can reduce the incidence of serious adverse reactions and maintain the treatment of statins.
Everyone should note that taking the next day is not a routine drug regimen for statins, but only a special usage for special patients , and it is not recommended to use it in ordinary patients. Because taking medicine the next day will reduce the blood drug concentration, affect the intensity of cholesterol control, and lead to a decrease in cardiovascular benefits.
Summary, the conventional usage of statins is once a day.Only when special groups experience statin intolerance, it is recommended to take the next day medication under the guidance of a doctor, but it is not recommended that ordinary people take the next day medication, that is, "not special, do not advocate" . If you have any questions about medication, please consult your doctor or pharmacist. I am Huazi, pharmacist. Welcome to follow me and share more health knowledge.
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