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Professor Chen Jie, the five "start from scratch" behind the success
In 2009, 37-year-old Chen Jie put down the identity of associate professor of gastroenterology at the First Affiliated Hospital of Sun Yat-sen University and went to the oncology specialist hospital to learn the treatment of digestive tract tumors from scratch; in 2010, 38-year-old Chen Jie left the field of gastrointestinal tumors with a crowded track and cleared out a blank "small tumor species" in China from scratch neuroendocrine tumors ... In 2021, 48-year-old Chen Jie established a neuroendocrine tumor specialist in at the Tumor Hospital of Fudan University. Behind the achievements of
is the story of Chen Jie's five "starting from scratch". The words "opportunity cost" and "comfort zone" seem to have never been in Chen Jie's dictionary.
All this starts with a small county in Sichuan Province...
The first time I started from scratch:
"World War II" postgraduate entrance examination, walked out of the basin
Chen Jie comes from a small county in southern Sichuan that is "saltable and sweet" Weiyuan - located between Zigong City , which produces salt and sugar Neijiang City . The family has three generations all teachers, but in Chen Jie's father's generation, his uncle began to study medicine, and he was the older generation West China . When he was a student, Chen Jie was a student who was a subject-oriented student. She was very poor in science, but her liberal arts score was very excellent, so she pulled the total score to the score line of key universities. In 1989, 16-year-old Chen Jie was admitted to the School of Clinical Medicine of West China Medical University. Chen Jie was influenced by her uncle in her uncle's family motto "If you don't be a good teacher, you will be a good doctor" sowed a seed of "salvation and saving the world" in her heart since she was a child.
During college, she never felt that studying medicine was difficult, and naturally maintained excellent results. However, luck makes people feel bad. During the junior fifth graduate exam, Chen Jie's total score far exceeded the admission line. However, because her English score was 1 point worse, she had to accept the allocation and could not choose the major she liked as she wished. Chen Jie resolutely decided to give up the opportunity and come to Sichuan Provincial People's Hospital to be a resident doctor, while preparing for World War II. Unlike now, we can take the postgraduate entrance examination again every year, according to the hospital's policy at that time, we had to wait for a full 5 years.
In other words, even if the "World War II" successfully came ashore, the former classmates might have been studying for a doctorate or even got married and had children, and they had just started to study for a master's degree. It takes a lot of courage and courage to make such a choice.
During the preparation period for the exam, Chen Jie was rotating in the Department of Internal Medicine at Sichuan Provincial People's Hospital. Her busy life in an inpatient doctor also laid a solid clinical foundation for her first step. Chengdu is a city with leisurely life. After work, Chen Jie did not choose to go to the comfortable life of "playing small mahjong and eating spicy hot pot". Instead, she did not give up studying for a day. When she was not at work, she read books in the West China campus library and went to the graduate class of her former classmates to take English classes. She persisted for three years. In 1997, Chen Jie, who was working hard, finally waited for good news - the hospital's policies were relaxed, and she could take the postgraduate entrance examination after working for three years.
"Opportunities are always left to those who are prepared" was fulfilled by Chen Jie. Chen Jie passed the exam without any suspense this time and walked out of the comfortable and pleasant Sichuan to Guangzhou, the hot land of reform and opening up of in the 1990s. Although the decision to study in Guangzhou was opposed by the whole family, Chen Jie resisted the pressure and resolutely came to Sun Yat-sen Medical University, starting another period of life.
Life tutor who influenced Chen Jie's life
was admitted to Sun Yat-sen Medical University. Chen Jie chose the major of gastroenterology and studied under the tutor who had an important impact on her life Chen Minhu .
Professor Chen Minhu was the youngest full professor at the First Affiliated Hospital of Sun Yat-sen University at that time, a returning scholar, a famous digestive expert, and one of the pioneers in the field of Helicobacter pylori research in China.
As a scientific research master, Chen Jie focuses on the immune-related research of Helicobacter pylori under the guidance of Professor Chen Minhu. When she was in her second grade of graduate school, her supervisor, Professor Chen Minhu, became the youngest full professor at the time, from , Zhongshan First Hospital, , to the youngest full professor at that time, and Chen Jie was also deeply appreciated by her supervisor. She then took the doctoral transfer exam and became Professor Chen Minhu's first master's and doctoral graduate student.
In 1999, Professor Chen Minhu went to Hong Kong's Chinese University of Hong Kong to study and met Professor Shen Zuyao, the then director of the Department of Internal Medicine and Drug Treatment at Prince Wells Hospital of the Chinese University of Hong Kong, and his postdoctoral fellow Professor Yu Jun. Professor Yu Jun had just returned to Hong Kong, China from Germany and engaged in basic research on digestive tract tumors in Professor Shen Zuyao's laboratory. One day, Professor Chen Minhu mentioned his "smart student" to Professor Yu Jun, hoping to recommend her to go to Hong Kong, China to study and complete her doctoral program. With the recommendation of his tutor, in 1999, Chen Jie went to Professor Shen Zuyao's laboratory in Hong Kong, China to study basic research with Professor Yu Jun. It is worth mentioning that although the research directions are different, Professor Yu Jun's basic tumor research gave Chen Jie a strong interest, sowing a seed for Chen Jie's later entry into the tumor field.
From left: Professor Shen Zuyao, Chen Jie, Professor Yu Jun, Professor Chen Minhu, Laboratory of the Chinese University of Hong Kong, 2000
Starting from scratch for the second time:
Give up the current hot research on Helicobacter pylori,
Basic research on digestive tract tumors from scratch
2002, 29-year-old Dr. Chen Jie graduated. At this age point, I had the idea of "setting up". At this time, Professor Chen Minhu reminded Chen Jie that if you want to be a doctor in a university teaching hospital, you should also go through more complete training - studying abroad. With the recommendation of Professor Chen Minhu and Professor Yu Jun, in 2002, Chen Jie came to the School of Medicine of Magdeburg University in Germany for postdoctoral research. The instructor was a famous gastroenter and Professor Peter Malfertheiner, who was then the president of the European Society of Digestive Medicine.
Professor Malfertheiner is very accomplished and academically influential in the field of Helicobacter pylori research. During his first conversation with Chen Jie, Professor Malfertheiner gave Chen Jie two choices: one is to join his main team, Helicobacter pylori research group; the other is to join his other "very small" digestive tumor research group, where there are only Associate Professor Matthias Ebert and two technicians. At that moment, Chen Jie recalled her five years of research experience so far. While she was getting deeper and deeper in the field of Helicobacter pylori, she was getting further and further away from the clinical practice, and she also remembered the attractive "new world" of tumors that she first saw when she followed Professor Yu Jun to study. Chen Jie told Professor Malfertheiner without hesitation that she would choose a tumor research group. During the two years of postdoctoral research, Chen Jie studied oncology from scratch and carried out basic research on digestive tract tumors under the leadership of Professor Ebert. Through two years of rigorous training, Chen Jie deeply realized that basic research should originate from clinical practice and then be classified into clinical practice. This "From bench to bed" translational research thinking is crucial to a clinician.
Working photos of German laboratory, 2003
started from scratch for the third time:
went to Sun Yat-sen University Affiliated Cancer Hospital for further study,
learned the clinical treatment of gastrointestinal tumors from scratch
000 after returning from Germany in 2004, 31-year-old Chen Jie finally got her wish and became a clinician in the Department of Gastroenterology at the First Affiliated Hospital of Sun Yat-sen University as she wished. From 2004 to 2007, while working as a gastroenterologist, Chen Jie applied for various scientific research funds, led graduate students to continue basic research on digestive tract tumors, and was successfully promoted to associate professor. Just as everything was booming, Chen Jie was becoming more and more confused: In Germany, Professor Ebert, as a professor of digestive science, will participate in the clinical diagnosis and treatment of digestive tumors, is a member of the multidisciplinary team of digestive tumors at the university's affiliated hospitals, and the basic research he did can also be closely integrated with the clinical practice. However, in China, although more and more patients with digestive oncology have been diagnosed in the gastroenterology department of general hospitals, the gastroenterology department of most hospitals is not responsible for the follow-up treatment of the tumor. Patients who can operate will be transferred to the surgery department, while those who cannot be operated will be transferred directly to the oncology department or oncology specialty hospital.The same was true for the Department of Gastroenterology at the First Affiliated Hospital of Sun Yat-sen University at that time. Therefore, Chen Jie felt that her basic research was completely separated from clinical practice. Can this situation be changed? In 2009, Chen Jie talked about her thoughts with her supervisor Professor Chen Minhu, and received support from her supervisor. She went to Sun Yat-sen University Affiliated Cancer Hospital to study clinical treatment of digestive tract tumors.
In the tumor hospital, Chen Jie studied under the famous digestive oncology experts Professor He Youjian, Professor Li Yuhong and Professor Xu Ruihua. On the first day of work at the Cancer Hospital, Professor Li Yuhong asked Chen Jie: "You are already an associate professor at the First Affiliated Hospital. How can I arrange for you when I come to study?" Chen Jie said: "Just treat me as a resident doctor, arrange for me as a bed, write medical records, and be on the front-line classes. How can I arrange for other advanced doctors?" As a further study doctor, Chen Jie's first patient was a patient with intestinal cancer, and the medical record reads "FOLFOX plan". Chen Jie asked Professor Li Yuhong, "Teacher Li, what is the FOLFOX solution?" Professor Li Yuhong was surprised and asked Chen Jie: "Do you really don't understand at all?" Chen Jie replied: "I really don't understand at all." From this day on, Chen Jie embarked on the path of learning the clinical diagnosis and treatment of digestive tract tumors from scratch.
At that time, Chen Jie, who lived near the hospital, left at 7 o'clock every morning and arrived at 9 o'clock in the evening. In addition to the patients she is in charge, Chen Jie will read the medical records of all the patients in the group, excerpt each case, and sort out all the details of the patient's treatment. The record book she used quickly turned into a thick little book. After studying so hard for half a year, Chen Jie finally opened the door to the clinical field of digestive tract tumors for herself.
After returning from his studies, Chen Jie started to treat gastrointestinal tumors from two beds in the Department of Gastroenterology, Zhongshan First Hospital, and later gradually expanded to four and six... And gradually established his own " brand effect " in the hospital. However, one morning when the shift was handed over, the instructor Professor Chen Minhu glanced at the tumor patients in the ward and asked a question that profoundly affected Chen Jie's career direction: "Think about it, even if I give you more beds to do chemotherapy, do you think you can do better than the tumor hospital? Will your academic achievements surpass those of the tumor hospital?" Chen Jie was enlightened after hearing this and decided to take her own path.
"When neuroendocrine tumors come knock on the door"
In July 2010, fate came knocking on the door again.
As a small tumor species that is considered rare tumors, for most Chinese doctors, it may be just some unfamiliar nouns scattered in textbooks of different eras, such as carcinoids, APUD tumors, islet cell tumors , etc. Before 2010, almost no one in China paid attention to this type of tumor. However, internationally, with the continuous increase in the incidence of this type of tumor, in 2010, WHO began to standardize the pathological diagnosis and naming of this type of tumor. Europe and the United States have also established corresponding professional societies to start standardized diagnosis and treatment and research on this type of tumor. At the same time, drug development for neuroendocrine tumors has also begun to accelerate. In 2011, the two major targeted drugs for neuroendocrine tumors, everolimus and sunitinib , completed the Phase 3 clinical trials of pancreatic neuroendocrine tumors, and were successfully launched. At the same time, another important therapeutic drug, long-acting octreotide, has also entered China. With the successful and accessible development of the drug, the unknown small tumor species of neuroendocrine tumors has instantly entered the era of targeted therapy. And as , Jobs, , diagnosed pancreatic neuroendocrine tumors, this "small tumor species" began to enter the public eye.
Since neuroendocrine tumors often occur in the digestive system, the instructor Professor Chen Minhu keenly saw this field that is almost blank in China, and gave Chen Jie another advice to promote her career: "If this field is blank in China, can you take a path that no one has taken? Maybe there will be a different world on this road, and maybe in a few years you will become an expert in this field."At this time, 38-year-old Chen Jie knew nothing about this field, but with the encouragement of her tutor, she decided to open up a path that no one had taken without hesitation.
and tutor Professor Chen Minhu
start from scratch for the fourth time:
give up the digestive tract tumor with a "visible future",
devoted himself to the "blank" neuroendocrine tumor
Although tutor Professor Chen Minhu has been playing the role of pushing Chen Jie out of comfort circle, Chen Jie's courage to overcome all obstacles after he has determined his goal. From the day he has made up his mind to start engaging in neuroendocrine tumors, Chen Jie stepped into a loneliness Field: Without anyone to teach, you start to learn theoretical knowledge from the most basic literature; without patients, you start to recommend yourself to all colleagues you know. If you encounter a neuroendocrine tumor patient, please recommend it to her and learn and treat it. In 2010, the WHO issued a new version of the pathological diagnosis standard for neuroendocrine tumors, which is a very important revision. So Chen Jie and her graduate students went to the pathology department. With the help and support of the famous pathology professor Xue Ling , they found the patients who were diagnosed by the first hospital of Zhongshan for 15 years from 1995 to 2010. They rediagnosed these patients according to the new version of the standards, and contacted these scattered patients through email and letters. This was also the diagnosis and treatment of Chen Jie. The first batch of neuroendocrine tumor patients. With the advent of the information age, Internet medical in China has also begun to rise. Chen Jie believes that online medical care must be an indispensable part of medical care in the future, especially for doctors with rare diseases, "the smell of wine is afraid of deep alleys." Internet hospitals may open the door to two-way communication between doctors and patients to the greatest extent. So in 2012, Chen Jie opened an online clinic of the Haodafu online platform. So far, Chen Jie has treated nearly 10,000 neuroendocrine tumor patients online on the Haodafu online platform. Neuroendocrine tumors are a tumor that requires a highly diagnosis and treatment of multidisciplinary teams. With the continuous enrichment of patients, in 2011, Chen Jie established the first multidisciplinary diagnosis and treatment team in Zhongshan First Hospital, the first neuroendocrine tumor specialty clinic and neuroendocrine Oncology Specialty Medical Group. At the same time, members of the multidisciplinary team began to carry out comprehensive clinical and translational research on neuroendocrine tumors.
Microendocrine tumors, the First Affiliated Hospital of Sun Yat-sen University,
"From zero" to "go international",
Chen Jie spent five years
At the end of 2011, Chen Jie got a precious learning opportunity and came to the Department of Endocrinology at the Churchill Hospital Affiliated to Oxford University in the UK, the Center of Excellence of the European Society of Neuroendocrine Oncology, and followed the famous neuroendocrine oncology expert and the president of the British Society of Neuroendocrine Oncology at the time. Professor Grossman studied. During the study, Chen Jie and Professor Grossman visited the clinic for the first time. Professor Grossman discovered that Chen Jie was able to independently express his own opinions on his patients and was very familiar with the content of the British neuroendocrine tumor diagnosis and treatment guidelines that had just been released at the time. Therefore, he was impressed by this doctor from China. According to the original plan, Chen Jie's training time in the UK was only six weeks, but Professor Grossman's recognition of Chen Jie gave Chen Jie more opportunities. At that time, the first advisory committee of the European Society of Neuroendocrine Oncology was held in London, England, so Professor Grossman invited Chen Jie to go with him. At the meeting, Professor Grossman introduced Chen Jie to experts from the Advisory Committee of the European Society of Neuroendocrine Oncology, and enthusiastically recommended Chen Jie to go to the Royal Free Hospital Affiliated to the University of London Hospital) studied with Professor Martyn Caplin, one of the founders of the European Society of Neuron Endocrinology and a famous neuroendocrinology expert. So Chen Jie started to get up at 4 o'clock every morning and traveled to and from Oxford and London. Speaking of this hard experience, Chen Jie said calmly: "If you want to learn something, you have to make all efforts."Professor Caplin is also a neuroendocrine tumor expert who is a gastroenterologist. What impressed Chen Jie's most profound learning experience with him was when she talked about why he devoted herself to the field of neuroendocrine tumors. The professor said that when he was an ordinary gastroenterologist, he met a young patient with a small intestine neuroendocrine tumor who came to see his outpatient clinic with severe carcinoid syndrome. At that time, the professor found that almost no one paid attention to this type of disease, and there was no reference diagnosis and treatment guide. Therefore, the professor decided to enter the field of neuroendocrine tumors. More than ten years later, he collaborated with several like-minded experts in Europe to establish the European Society of Neuroendocrine Oncology. Although the time is short, Chen Jie opened up an international vision for the disease of neuroendocrine tumors and has since established close ties with top international experts in the field. In 2015, the new European Society of Neuroendocrine Oncology was established. Chen Jie was recommended to be a member of the second advisory committee and the only Asian expert. In 2020, Chen Jie was invited to become a member of the European Society of Oncology (ESMO) Neuroendocrine and Endocrine Oncology, as well as a member of the Medical Advisory Committee of the International Neuroendocrine Oncology Alliance (INCA).
Oxford University Churchill Hospital, with Ashley Professor Grossman
UK, University of London , Royal Free Hospital, with Martyn Professor Caplin
The fifth time starting from scratch:
bid farewell to Guangzhou,
came to Shanghai to establish a specialty in neuroendocrine tumor
Since entering the field of neuroendocrine tumors, Chen Jie has always hoped to establish an independent neuroendocrine tumor department in the future, so that patients can be treated more professionally and accurately. Chen Jie's fate with the Affiliated Cancer Hospital of Fudan University gave her this opportunity.
In 2015, Yu Xianjun, director of Pancreatic Surgery, Fudan University Affiliated Cancer Hospital The Pancreatic Cancer Professional Committee of the Chinese Anti-Cancer Association led by the professor hopes to establish a neuroendocrine oncology group in the special committee, so Professor Yu invited Chen Jie to serve as the leader of the academic group. Since then, Chen Jie has begun a full-scale academic cooperation with the Pancreatic Surgery Department of the Affiliated Oncology Hospital of Fudan University.
2021, the Affiliated Oncology Hospital of Fudan University extended an olive branch to Chen Jie, inviting Chen Jie to Shanghai to establish an independent neuroendocrine oncology department. Although he has lived in Guangzhou for more than 20 years and has entered a comfortable circle, when the ideal of establishing the neuroendocrine oncology department comes true, Chen Jie still chose to take a firm step towards it. 2021 In July 2019, Chen Jie bid farewell to Guangzhou and came to Shanghai. He founded the Department of Neuroendocrine Oncology Hospital Affiliated to Fudan University. This is also the only neuroendocrine oncology specialty in China and has become the chief expert of multidisciplinary neuroendocrine oncology. As a top domestic tumor specialty hospital, Fudan Tumor has given all-round support to the new tumor species of neuroendocrine tumors. Chen Jie did not disappoint and led the multidisciplinary team of Fudan Tumor. In just over a year, it has provided diagnosis and treatment plans for more than 2,000 new patients with neuroendocrine tumors from all over the country. At the same time, it has also received key project funding from the National Natural Science Foundation of China's Rare Tumor Special Fund. In 2022, Fudan University Affiliated to Tumor As a support unit, Chen Jie initiated the establishment of the China Anti-Cancer Association's Neuroendocrine Tumor Professional Committee, and prepared the first edition of the China Anti-Cancer Association's Neuroendocrine Tumor Diagnosis and Treatment Guide, which has taken another big step in promoting the professionalization and standardization of the diagnosis and treatment of neuroendocrine tumors.
Multidisciplinary Team of Neuroendocrine Tumor Hospital Affiliated to Fudan University
In nearly 30 years of career, Chen Jie has experienced many times starting from scratch, and each time starting from scratch, she has taken a step towards her career ideal. A sentence she often encourages others is: "As long as you work hard, nothing is impossible.”
Expert Profile
Chen Jie
Chief Physician, Professor Doctoral Supervisor
Fudan University Affiliated Tumor Hospital Neuroendocrine Oncology Hospital Multidisciplinary Chief Expert
Director of Neuroendocrine Oncology Center of Fudan University Affiliated Tumor Hospital
l0Director of the Department of Head, Neck and Neuroendocrine and Oncology Hospital of Fudan University
Advisory Committee Member of the European Society of Neuroendocrine and Oncology (ENETS)
Advisory Committee Member of the European Society of Neuroendocrine and Oncology (ESMO) Neuroendocrine and Endocrine Oncology Group
International Neuroendocrine and Oncology Alliance (INCA) Medical Advisory Committee
Central member of the Neuroendocrine Oncology Professional Committee of China Anti-Cancer Association
Central leader of the Pancreatic Cancer Professional Committee of China Anti-Cancer Association Neuroendocrine Oncology Group (CSNET)
Central member of the Tumor Endocrine Professional Committee of China Anti-Cancer Association
Chinese Medical Association Gastrointestinal Branch Gastric Intestine Deputy Head of the Hormones and Neuroendocrine Oncology Group
Pancreatic Disease Branch of the Chinese Medical Association Pancreatic Neuroendocrine Oncology Committee
ENETS Official Journal of Neuroendocrinology Senior Editorial Committee
Journal of Pancreatology Editorial Committee
Chinese Cancer Magazine Editorial Committee
Chinese Digestion Magazine Communication Editorial Committee
is committed to the diagnosis and treatment of neuroendocrine tumors, and has published more than 90 related articles on neuroendocrine tumors, and has received special funding from the National Natural Science Foundation for Rare Tumors. As the main author, he participated in the gastrointestinal hormones and neuroendocrine group of the Chinese Medical Association's Digestive Disease Branch "Gastric Intestine Pancreatic Neuroendocrine Tumor Diagnosis and Treatment Experts "The "Guidelines for Diagnosis and Treatment of Pancreatic Neuroendocrine Tumors" of the Pancreatic Surgery Group of the Surgery Branch of the Chinese Medical Association. As a member of the ENETS Advisory Committee, he participated in the formulation of the clinical diagnosis and treatment standards for ENETS neuroendocrine Tumors in 2017. As the editor-in-chief, he led the formulation of the first edition of the "Guidelines for Integrated Diagnosis and Treatment of Neuroendocrine Tumors (2022 Edition)" of the Chinese Anti-Cancer Association.
This article was first published: Medical Tumor Channel
Author: Charles
Editor: Sweet
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Original article If you need to reprint, please contact the authorized
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