"Doctor Zhang, I heard that he had been given a blood lipid-lowering vaccine every six months, why can't we buy it here? Is this medicine reliable? Can you tell me?" This is a question raised by many fans who need to control low-density lipoprotein and cholesterol. Today, Dr. Zhang will explain this issue to you clearly.
A lipid-lowering drug for half a year
In the past two years, the most common question that friends in front of my mobile phone asked me is the question mentioned above about the "blood-lowering vaccine" once every six months. Today I will use the words of ordinary people to explain this issue clearly to everyone. If you follow this topic, you must finish reading this article today.
Strictly speaking, the blood lipid-lowering strength of this lipid-lowering drug is stronger than the most commonly used statins and ezemebs at this stage. The mechanism of action of is to affect the " messenger RNA" in the human body, thereby blocking the expression of DNA gene sequences to achieve the purpose of lowering blood lipids. Speaking of this, many people don’t understand it. Dr. Zhang gave you an example: If DNA is compared to the headquarters of the human body, the command issued by DNA sequence can form many protein in the human body, including some active protein that can regulate blood lipid . When there is abnormality in the human DNA, including the genetic abnormalities inherited by parents and their own gene mutations, some active proteins will become incorrect, and their functions will become abnormal, which will cause various diseases to the human body. This is how familial hypercholesterolemia , which is often heard. How to block this process? This is what human science and medicine have been thinking about.
DNA sequence errors will lead to various diseases
. Fortunately, the DNA command does not work on its own. It generally guides the formation of proteins, and requires a little guy called "messenger RNA" to help. At this time, as long as humans find ways to intervene in this "messenger RNA", they can block many human disease processes. The lipid-lowering medicine that everyone has been looking forward to is used once every six months, which is how to complete the task of lowering blood lipids.
Regarding this drug, the data on the third phase clinical trials in my country have also been released. Look at the picture, in addition to the significant reduction of low-density lipoprotein, it has effects on total cholesterol, non-high-density lipoprotein, apolipoprotein B and lipoprotein (a). Among them, the reduction of non-high-density lipoprotein, the non-high-density lipoprotein can reach 46%. Lipoprotein (a) can also be reduced by 20%. (Note that this drug is not specifically used to reduce lipoprotein a. The drug specifically used to reduce lipoprotein a is called Pelacarsen. It is an antisense oligonucleotide preparation and is also undergoing phase 3 clinical trials in Europe.)
Phase 3 clinical data conducted in China
Inclisiran This small interfering RNA preparation is given once every six months because of its super long half-life . Therefore, many people who are afraid of trouble taking medicine every day have been paying attention to the progress of this drug. Some people even heard that this drug is available in Hainan, and told everyone that even those who are used in Hainan are mostly included in the Phase 3 clinical trials. The launch of this drug should be in the near future. Of course, the use of any drug must be carried out under the guidance of a professional doctor, and everyone must remember this.
If there is new news in the later period, Dr. Zhang Zhiying will also give a popular science explanation as soon as possible. Everyone can continue to pay attention to me. It is not easy to write popular science articles, but it is even more difficult to write reliable medical knowledge to everyone. Therefore, everyone thinks this article is good, so you can like, comment, and forward it more to benefit more people who need it.
More knowledge about blood lipids, especially some of the blood lipids mentioned above that everyone doesn’t understand. You can click the “Stay Away from Hyperlipids” column below to get it. After watching the video, you will be clearer:
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