, let's learn about nifeding . Nifine is a dihydrial antagonist. By selectively inhibiting calcium ion , enters the cross -membrane transfer of myocardial cells and smooth muscle cells, suppress calcium ions to release from the cell, and expands the plasma calcium ion concentration without changing the concentration of plasma calcium ion concentration. Crown, inhibitory myocardial contraction, reducing myocardial oxygen consumption, diastolic peripheral vascular resistance, reducing the posterior cardiac load and other pharmacological effects, oral absorption is complete, the biological utilization is high, the binding rate with plasma protein is as high as 90%, and the half -life is two -way. Among them, alpha The half-life period is 2.5-3 hours, the β phase half-life is 5 hours. After the liver metabolism, 80%are excreted through the kidneys, and 20%are excreted with the feces. Clinically, it is mainly used to treat mutant angina. Chronic stable angina pectoris and hypertension , etc., his adverse reactions are related to dosage. It is common to have peripheral edema, dizziness, headache, nausea, fatigue, face flushing, hypotension , palpitation , constipation, diarrhea, etc.
ammline is similar to the structure of Nifine Piece, which is also a dihydrial calcium calcium antagonist. The pharmacological effect is similar to the nonopipipine. Unlike the nonopine, ammonia ground is ionic under the physiological PH value. Existence, when the PH value is low (such as ischemia), it can be closely combined with the calcium ion channel to preferential blocking the calcium channel of exfoliating cells. There are also studies that it may have the characteristics of dual receptor binding. Compared with nonetopicine, tobopine has a strong selectivity of blood vessels and has a prominent effect on the surrounding blood circulation . The mechanism of alleviating angina pectoris has not been fully clear. Oral absorption is well absorbed, and it is not affected by food. The biological utilization is lower than that of nifedenopine. The binding rate with plasma protein is as high as 97.5%. Be more, generally once daily medication, clinically used to treat chronic stable angina pectoris, mutant angina pectoris, and hypertension, and adverse reactions are similar to nifedine.
is only a personal point of view. It is not used as a basis for medication. Please use medication under the guidance of the doctor. If you have any questions or opinions, please leave a message below the article.
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