Gastroenterology diseases are common clinical diseases and often occur. Many diseases are not acute and critical , such as chronic gastritis, acute gastroenteritis, stomach, duodenal ulcer , diarrhea, constipation, indigestion, etc., but recurrent chronic diseases. Some people become good doctors after a long illness, and they are unwilling to go to the hospital but go to the pharmacy to buy medicine for treatment.
Gastroenterology drugs have many varieties and a wide range of uses. A variety of different drugs can be used for the same disease, and the same drug can cure a variety of diseases. Some drugs can enhance the efficacy, while some can reduce the efficacy and even increase adverse reactions. Therefore, how to avoid unreasonable medication is not only the responsibility of the doctor, but also what patients need to pay attention to when using medication.
Below will introduce some reasonable medication issues for common gastroenterology drugs for your reference.
1. Acid inhibitors and acid drug
H2 receptor antagonists such as samitidine, ranitidine , famotidine , and proton pump inhibitors (PPI) such as omeprazole , rabeprazole , pantoprazole , iprazole, etc. are all inhibitors. In principle, these two types of drugs are not suitable for use unless oral PPI can be taken during the day and H2 receptor antagonists are added at night.
acid preparation drugs include sodium bicarbonate , aluminum magnesium carbonate, aluminum hydroxide , magnesium hydroxide , basic bismuth carbonate (bismuth subcarbonate), tummy soupping , stomach must be treated, tummy , gastric equality. This type of drug relieves symptoms by neutralizing gastric acid , and its effect is fast, but the acid production effect is not as good as that of acid-suppressing drugs.
acid-suppressing drugs and acid-producing drugs are generally not used in combination, but sometimes in order to enhance the effect, acid-producing drugs are often added to temporarily relieve symptoms on the basis of acid-suppressing drugs. However, the combined use of the two requires attention to the course of treatment and cannot be used for a long time.
Iron agent is mainly absorbed in the form of ferrous ion in the duodenum and proximal jejunum. Gastric acid can increase the solubility of the iron agent , and promote the conversion of unabsorbed trivalent iron into absorbable divalent iron, thereby helping the absorption of iron. Acid-inhibiting drugs can inhibit the conversion of iron and affect its absorption.
Omeprazole has an enzyme inhibitory effect and can delay the elimination of drugs metabolized by the liver cytochrome P450 system (such as dicoumarin , diazepam, phenytoin sodium, warfarin, nifeding) in the body. When this drug is used with the above drugs, the dosage of the latter should be reduced as appropriate.
2. Gastrointestinal motility drugs
Promoting drugs include metoclopramide (Weifuan), dopanidone, mosapride, etc., which can increase gastrointestinal motility, improve digestive function, and reduce symptoms such as abdominal distension. The side effects include abdominal pain, diarrhea, etc.
This type of drug can be used in combination with acid-suppressing drugs or acid-producing drugs, which can enhance the efficacy, but the prokinetic drug can accelerate gastrointestinal motility and reduce the absorption of acid-suppressing agents. At the same time, acid inhibitors will reduce the bioavailability of prokinetic drugs. If necessary, the two medicines should be separated by at least 1 hour.
When patients suffer from abdominal pain and bloating at the same time, they cannot use anisopsamine and prokinetic drugs at the same time. The two antagonize each other.
3. Gastric mucosal protective agents
Commonly used gastric mucosal protective agents include colloidal pectin bismuth , sulfalumina gel, misoprostol, tepredone , rebapat, jihaifali, etc., which can protect the gastric mucosa and enhance the resistance of the gastric mucosa , erosive gastritis and duodenitis , etc.
There are many varieties of this type of drug. Although it is selected according to different diseases and symptoms. If you treat Helicobacter pylori, you often choose bismuth agents, and sulfalumina for ulcers. If you have gastric mucosa erosion, misoprostol, tepredone, rebaptide, etc. Generally, only one is enough. Do not use multiple protective agents in combination.
This type of drug combined with acid-suppressing drugs can enhance the efficacy, but bismuth agent (such as colloidal bismuth pectin) is deposited in the gastric mucosa in the form of bismuth salt, but this requires the action of gastric acid to take effect. Another mucosal protector, sulfaluminum, can exert mucosal protective effect by forming sucrose sulfate complex anion, and it also needs to be ionized in an acidic environment to exert its efficacy.Therefore, if the two drugs are combined, it must be more than 1 hour apart.
4. Microecological preparation
Most of this type of drugs are live bacteria preparations such as bifidobacterium, Clostridium sarcoplasma , Bacillus subtilis, lactic acid bacteria , Enterococcus faecium , Bacillus licheniformis, Brazza (fungus), etc. Different preparations often combine two to four bacteria, such as bifidobacterium triple live bacteria including Bifidobacterium , Lactobacillus acidophilus, and Streptococcus faecalis .
Since it is a live bacteria preparation, it often requires certain conditions to preserve it. It is generally stored in a cold and dry environment, and it is best to store it at a low temperature of 8-12 degrees Celsius.
is a live bacteria preparation, so as to try to use it in combination with antibiotic to avoid reducing the efficacy of the drug. If you really need to use antibiotics, the two drugs need to be separated by about an hour. It is best to use microecological preparations after the antibiotic treatment course, but Brazil is exceptional because it is a fungus and is not sensitive to antibiotics.
5. Antidiarrhea drugs
Commonly used drugs include loperamide (Yimetane), defenolate (phenethylphenyl), montmorillonite powder (Smithatad), pivirimeryl bromide, etc.
antidiarrhea should generally be used under the guidance of a doctor, because some diarrhea cannot blindly apply antidiarrhea. For example, early diarrhea is conducive to the excretion of bacteria and virus from the intestines. Rapid stop diarrhea will cause bacterial toxin to be absorbed from the intestines, aggravate the symptoms of poisoning, and have the side effects of "closing the door and leaving the enemy behind".
Indigestion diarrhea, use antidiarrhea and do not use
for indigestion. ml1 lactase-generating and digestive enzyme-accelerated digestive drugs are used together because antidiarrhea drugs can reduce the efficacy of such drugs.
montmorillonite powder can form a protective film in the intestines, affecting the efficacy of antibiotics. If it must be used at the same time as antibiotics, the time between the two should be taken should be more than 2 hours apart.
When applying antidiarrhea drugs, it should actively treat the cause, such as infectious abdomen. Digestion should be treated with anti-infection, and indigestion should be given digestive drugs. For severe diarrhea, should also rehydrate to correct the acid-base balance disorder of water electrolytes.
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6. Chinese patent medicine in gastroenterology
gastroenterology has many Chinese patent medicines. They often choose according to different symptoms, but many Chinese medicine prescriptions are roughly the same, and their effects are somewhat similar. Generally, only one Chinese patent medicine is used in clinical practice. , if there is no curative effect, but now many people use 2 or more Chinese patent medicines in combination, which is not only useless but also harmful.
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