Gastric mucosal protective agents can strengthen the defensive function of the gastric mucosa and play a positive role in the healing of ulcers. They are one of the basic drugs for the treatment of peptic ulcers and gastroesophageal reflux disease.

[Source: Maanshan Municipal Market Supervision and Administration Bureau]

Gastric mucosal protective agent can strengthen the defense function of gastric mucosa and play a positive role in the healing of ulcers. It is effective in the treatment of peptic ulcer and gastroesophageal reflux disease. One of the basic medicines .

There are currently many gastric mucosal protective agents, and their mechanisms of action and taking times are different. Most of them are related to meal times and cannot be generalized. Let’s find out together!

10 Correct use of gastric mucosal protective agents

Aluminum magnesium carbonate tablets

Aluminum magnesium carbonate is both a mucosal protective agent and an antacid . It can absorb pepsin , combine with bile acid , and can also stimulate the gastric mucosa. Increases the synthesis of prostaglandin E2, thereby enhancing the barrier function of the gastric mucosa.

Aluminum magnesium carbonate acts quickly as an antacid, with mild and long-lasting effects. Because it can bind bile acids, it has a good effect on bile reflux gastritis .

Aluminum magnesium carbonate contains two metal ions, aluminum and magnesium, which offset each other's adverse reactions of constipation and diarrhea. However, it should be noted that the two metal ions of aluminum and magnesium can interfere with a variety of drugs such as tetracyclines, iron , and quinolones. The absorption of -like, anticoagulants , digoxin, ranitidine , etc. must be staggered when taking them.

▌How to take: Chew it 1 to 2 hours after a meal, chew 1 to 2 tablets before going to bed or when you have stomach discomfort.

Sucralfate suspension

Sucralfate can combine with positively charged proteins on the ulcer surface to form a protective barrier; adsorb bile salts and bile acids to prevent gastric acid and pepsin erosion; complex with pepsin , inactivating pepsin. Can be used to treat peptic ulcers.

▌How to take: 1 hour before meals and before going to bed, 2 to 4 times a day, 5 to 10ml at a time.

Teprenone capsules

Teprenone can directly increase mucus secretion and promote cell regeneration, thereby reducing damage to the gastric mucosa, and can restore damaged gastric mucosa and even ulcers, directly protecting the gastric mucosa. effect.

▌How to take: Take after meals (bioavailability is significantly increased when taken after meals compared with taking on an empty stomach), three times a day, one pill at a time.

Compound Glutamine Granules

Compound Glutamine Granules is a compound preparation composed of sodium azulene sulfonate and L-glutamine . Sodium azuresulfonate can directly act on inflammatory mucous membranes and has anti-inflammatory effects; glutamine promotes the synthesis of hexosamine and glucosamine, the components of gastrointestinal mucosal epithelium, and can promote the regeneration of ulcer tissue. Enhance intestinal mucosal barrier function.

▌How to take: Take before meals, 3 times a day, 1 bag each time, dissolve in 30ml warm water and take.

Rebamipide tablets

Rebamipide tablets protect the gastrointestinal mucosa by increasing the prostaglandin E2 content in the gastric mucosa, increasing gastric mucus volume and blood flow, inhibiting damage to the gastric mucosa by aspirin, ethanol, etc.

▌How to take: 3 times a day, 1 tablet at a time, take orally in the morning, evening and before going to bed.

Isoladine Tablets

Isoladine Tablets: By increasing the contents of CAMP, prostaglandin , reduced glutathione and mucus glycoprotein in gastric mucosal cells, it strengthens the binding between gastric mucosal epithelial cells and enhances The stability of the mucosal cells themselves to play a mucosal defense role.

▌How to take: 2 tablets (4mg) a day, divided into 1 to 2 times.

Montmorillonite Powder

Montmorillonite Powder has a strong fixation and inhibitory effect on viruses and bacteria in the digestive tract, making them lose their pathogenic effect. In addition, montmorillonite powder has a strong ability to cover and protect the montmorillonite powder membrane of the digestive tract, and can repair and improve the defense function of the mucosal barrier against attacking factors. Mainly used for acute and chronic diarrhea .

▌How to take: Take on an empty stomach, 3 times a day, dissolve one bag (3g) with half a cup of warm water (about 50ml) and take it. Double the first dose when treating acute diarrhea .

Bismuth Potassium Citrate Capsules

Bismuth Potassium Citrate Capsules form a diffuse protective layer in the acidic environment of the stomach to cover the ulcer surface, preventing gastric acid and enzymes from invading ulcers; they can reduce pepsin activity and promote mucosal release It has the function of prostaglandins, thereby protecting the gastric mucosa; it has a killing effect on Helicobacter pylori (HP), thus promoting the healing of gastritis .

▌How to take: 4 times a day, the first 3 times half an hour before meals, the 4th pill 2 hours after dinner; or 2 times a day, 2 pills in the morning and evening. Note that bismuth potassium citrate cannot be taken for a long time. In addition, milk and antacid can interfere with its absorption and cannot be taken at the same time.

Giferate tablets

Giferate tablets are acacia geraniol acetate, which can promote ulcer repair and healing, increase gastric mucosal prostaglandins, promote mucus secretion, enhance gastric mucosal barrier, expand gastric mucosal microcirculation, and improve blood flow. distributed.

▌How to take: 3 times a day, 1 to 2 tablets each time.

Ecabet Sodium Granules

Ecabet Sodium Granules can form a protective film in the stomach. The covering effect on the gastric mucosa is not affected by changes in the pH value in the stomach. It can also inhibit the activity of pepsin and has the ability to inhibit Helicobacter pylori role.

▌How to take: Adults take 1 bag at a time, 2 times a day (after breakfast, before going to bed).

Source: Anhui Drug Supervision

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