
Xue Lu followed King Yan Zhu Di to participate in the Jingnan battle and made many military achievements along the way. For example, in the crucial Zhending Battle, Xue Lu fought a duel with the enemy's left deputy general Li Jian. As a result, Xue Lu stabbed him off the horse and captured him alive. After this battle, he was promoted to commander.
In the Battle of Dongchang, he defeated hundreds of southern soldiers with fifty cavalry and achieved a small local victory, but the battle ended with Zhu Difang's failure. Zhu Di led his army to flee in a panic. The commander of the Southern Army, Shengyong, and the commander of the Southern Army, was defeated by Xue Lu.
Also, in the Battle of Hutuo River, Zhu Di's right army could not withstand the enemy's attack. Xue Lu rushed over to support dozens of battles and successfully reversed the situation.

In the Battle of Shanjiaqiao, Xue Lu was unfortunately captured by the enemy's chief general in the fierce battle. He seized the opportunity to break free, drew his sword and killed the guards, successfully returned to the battlefield with his own strength, continued to fight hard, and finally defeated the Ping'an Army.
or above are all major achievements made by Xue Lu in the Jingnan Battle. When Zhu Di took over Nanjing and successfully became the Emperor Yongle , he was promoted to the assistant governor for his merits, and later became the general governor.
In the eighth year of Yongle , Xue Lu followed Zhu Di to participate in the first northern expedition to Mongolia as General of the Cavalry, and was promoted to the right governor after returning.

Xue Lu once wrote a letter to say that since ancient times, people must be trained first, but now many children of martial officials have nothing to do. If an emergency war occurs in the future, there may be a dilemma where no one can be used.
Zhu Di agreed with Xue Lu's letter and ordered him to be responsible for training the tens of thousands of young soldiers sent from various places.
In the 18th year of Yongle, when Zhu Di officially established his capital in Beijing, he also appointed Xue Lu as the Marquis of Yangwu, with an annual salary of 1,100 stones. During the Fourth and Fifth Northern Expeditions in the 21st and 22nd year of Yongle, Xue Lu both followed the army and was responsible for leading the Right Strike Army.

Renzong Emperor Zhu Gaochi When Xue Lu succeeded to the throne, he was appointed as the governor of the Left Army, and was appointed as the Prince's Taibao, and was given a coupon. In the same year, he was appointed as the general officer and was prepared to rule the outside world. Soon, he made contributions to capturing the enemy's enemy, and his salary increased by 500 stone. Later, he wore the seal of General Zhenshuo and was ordered to patrol the border and open equal places.
After Emperor Xuanzong Zhu Zhanji succeeded to the throne, the rebellion occurred in King of Han Zhu Gaoxu. After weighing the pros and cons, Zhu Zhanji decided to lead the army in person and appointed Xue Lu as the vanguard, easily putting down the rebellion. Zhu Gaoxu chose to surrender, and Xue Lu and the Secretary of the Han Dynasty Zhang Ben were ordered to stay in Le'an, the vassal state of the Han King.

When the spring of the following year, Xue Lu was ordered to inspect the various prefectures in the south of the capital, and then went north again to patrol the border Kaiping. Since then, he has been stationed in Xuanfu for a long time, and has defeated the invasion of Ola many times.
Xue Lu finally died of illness in July of the fifth year of Xuande at the age of 73.