Not long ago, the topic related to "Huang Zitao helps fans talk about nine-price" has been on the hot searches on Weibo many times, attracting 79 million netizens to watch. Before discussing what nine-valent is, let’s first understand what cervical cancer is. Cervical cancer is o

Not long ago, the topic related to " Huang Zitao helps fans talk about nine prices" has been on the hot search on Weibo many times, attracting 79 million netizens to watch. Before discussing what is nine-valent, let’s first understand what is cervical cancer .

Cervical cancer is one of the most common malignant tumors in women, and its incidence rate ranks second among female tumors in the world. Scientific research shows that 99.7% of cervical cancers are related to human papillomavirus (HPV).

Scientific research shows that 99.7% of cervical cancers are related to human papillomavirus (HPV). /Photo·unsplash

Currently, there are three different types of HPV vaccines that can be injected on the market, namely bivalent, tetravalent and nine-valent HPV vaccines. The "price" of a vaccine refers to the number of HPV virus types covered by the vaccine. The bivalent HPV vaccine is targeting HPV16, 18; the quadrivalent HPV6, 11, 16, 18; the nine-valent vaccine is targeting HPV6, 11, 16, 18, 31, 33, 45, 52, and 58.

The "nine-valent" that Huang Zitao talks about is the nine-valent HPV vaccine. It is currently the HPV vaccine with the largest number of virus types, the highest prevention rate for cervical cancer, and the widest preventable disease types.

Due to the large population base of my country and the approved nine-valent HPV vaccine is mainly imported. Due to the speed of issuance of vaccines, it is difficult to make an appointment and long queue time, and it is still "hard to get a shot".

The nine-valent HPV vaccine in the circle of friends

Xiaoshuang is a member of the Beijing migrant tribe and a grassroots employee of a major Internet manufacturer. She described her experience of getting the nine-valent HPV vaccine as "taking the last bus."

Young women are beginning to pay more attention to their own health rights. (Photo/ Visual China )

Originally, she was not very aware of getting the HPV vaccine, but a year ago, her 49-year-old mother suddenly found that HPV6 and HPV28 were positive at low risk. In order to avoid cross-infections that may exist in daily life in the future, her mother asked her to get the nine-valent HPV vaccine as soon as possible. So, she immediately searched the Internet for all the units that can be vaccinated with nine-valent HPV vaccine in Beijing, and called each one to inquire. The result is that almost all public hospitals and community hospitals need to queue for more than one year. If she waits for another year, she will miss the nine-valent vaccination time. She turned her eyes to a private medical institution. When she called for consultation, the other party told her that she could get vaccinated as early as next week after asking about her age.

The price of nine-valent vaccine is a huge expense for Xiaoshuang, but compared with health, 5,300 yuan is not that important. /Photo·unsplash

Xiaoshuang's average monthly salary is around 9,000 yuan, while the price of receiving the nine-valent HPV vaccine in the private hospital is 5,300 yuan, which is 1,300 yuan higher than the price in public and community hospitals.

She said: "This is a huge expense for me, but compared with health, 5,300 yuan is not that important."

Although my country imports tens of thousands of HPV vaccines every year, it is still normal to find a shot. Moreover, the nine-valent HPV vaccine strictly implements the vaccination age range of 16-26 years old. Therefore, most women of appropriate age will concentrate on this age group to get vaccinated, which in disguise increases the difficulty of vaccination.

Nine-valent vaccine is hard to find now.

Xiaoshuang said that it is already a blessing to be able to catch up with this "trend" before the age of 26. She also posted on WeChat Moments about this, telling her experience of successfully receiving the nine-valent HPV vaccine within a week, which attracted the envy of female friends.

However, it is also a "circle of friends", Liu Ziqi has been questioned and ridiculed for her experience of getting the nine-valent HPV vaccine. As early as high school, Liu Ziqi knew something about HPV, and she knew that the best stage of vaccination was "before sex". In 2019, when she first entered her freshman year, she successfully made an appointment for herself and received the nine-valent HPV vaccine.

Liu Ziqi's university is located in a second-tier county-level city. Most citizens and classmates around them have far less understanding of HPV vaccines, and they simply equate it with sexual transmission.

At present, there are still many women in China who have biased their perceptions about HPV vaccines./Photo·unsplash

When she learned that she had received a "useless" nine-valent vaccine for more than 4,000 yuan, many students' first reaction was: "Does she have any problems?" Some students asked her bluntly: "All such expensive vaccines have been vaccinated, are you ready to start opening up sex?" "Tell me, have you had sex for a long time?"

These remarks made her very painful, and she couldn't help but think: "If you move your fingers and check them online, you won't have such misunderstandings."

Even now, there are still people who will have related ideas about "HPV" and "HIV", and their cognition is only at the level of "sexuality". Therefore, once someone mentions the relevant vocabulary, whether it is the virus itself or the vaccine, "confused sexual behavior" is still a difficult prejudice.

HPV vaccine still has a long way to go. (Photo/Visual China)

But the fact is that HPV infection with has many ways, including sexual contact transmission, indirect contact transmission and maternal and child transmission. If you accidentally come into contact with an infected person's towel, bath towel, or some irregular gynecological examination at a certain moment, you may also have cross-infection.

Today, there are still big differences in the understanding of HPV and its vaccines in various regions, and relevant institutions have a long way to go to popularize HPV vaccines.

Girls who received HPV vaccine in European and American countries

On the afternoon of August 28, 2006, a pair of Queensland sisters received the world's first HPV vaccine at Alexandria Hospital in Queensland, Australia; on the afternoon of July 31, 2017, a 20-year-old girl from Texas, Shandong Province injected the first HPV vaccine from mainland China at the local street health service center.

December 14, 2021, in Lianyungang, Jiangsu, a seventh-grade girl from Donggang Middle School was listening to experts’ explanation of HPV vaccination knowledge. (Photo/Visual China)

"The First Injection in Mainland China" and "The First Injection in the World" are 11 years apart. Behind these 11 years, there is a reality that is still not optimistic: China accounts for 28% of the world's new cervical cancer cases, but the nine-valent vaccination rate for key populations is less than 1%.

Therefore, due to various objective and realistic conditions, women who failed to successfully receive the nine-valent HPV vaccine in mainland China have turned their attention to European and American countries such as the United Kingdom and Canada where vaccination restrictions are more relaxed and vaccine stocks are sufficient.

Wang Hanning is the earliest woman in China who received HPV vaccine. In 2016, while studying in Canada, she learned that the local government’s medical insurance for international students could reimburse the cost of getting the HPV vaccine. However, due to concerns about the side effects of the vaccine and whether it will mutate, she did not receive the vaccine directly.

Due to the more sufficient foreign vaccine stock, many women choose to get vaccinated abroad.

Until by chance, she communicated with a biology doctor. The other party said: "The history of HPV vaccine is released is quite long, and there is no possibility of sudden mutation. It can only be said that it was discovered in an extremely long process that it would have some impact on a certain type of population, and this impact has individual differences. At present, there is a special, known and obvious benefit of vaccination, that is, it can indeed resist HPV." After a conversation with

, Wang Hanning was persuaded by the doctor. At the age of 23, she went to a local hospital in Canada to get the HPV vaccine. However, when she was vaccinated, the nine-valent HPV vaccine had not yet been launched. She adopted a combination of the first and second doses as quadrivalents and the third dose as nine-valents.

When Wang Hanning was vaccinated, the nine-valent HPV vaccine had not yet been launched. She adopted a combination of the first and second doses for quadrivalents and the third dose for numerical.

Compared with China, European and American countries have more relaxed policies on HPV vaccination, and many international students will also choose to get HPV vaccination during their study abroad.

"I know it is difficult to queue up in China, so I got it abroad. I have to get it sooner or later." In 2019, 26-year-old Huang Miao was successfully vaccinated with the nine-valent HPV vaccine while studying in London, England.

and Wang Hanning have different vaccination experiences in Canada. The locations for HPV vaccination in the UK can be divided into hospitals and pharmacies. Huang Miao made an online appointment for HPV vaccination in a chain pharmacy called "boots", and then went to the offline "boots" physical pharmacy for vaccination.

She recalled: "The nine-valent HPV vaccine abroad is more like a certain drug in a pharmacy, which is more common. Moreover, the vaccination personnel are not necessarily doctors, but clerks with medical qualification certificate ."

Both are international students, Huang Miao, who is studying in the UK, did not enjoy Wang Hanning's "free vaccination" policy in Canada, and could only pay for it at his own expense. The price of 3 vaccination is more than 3,000 yuan. /Photo·unsplash

is the same as the domestic HPV vaccination process. Before vaccination, the doctor will show you the complete, unopened nine-valent HPV vaccine. Unlike in China, the UK does not restrict the age of under 26 to receive the nine-valent HPV vaccine, so Huang Miao has become the vaccinator for the nine-valent HPV vaccine. However, Huang Miao, who is also an international student, did not enjoy Wang Hanning's "free vaccination" policy in Canada, and could only pay for it at his own expense. The price of 3 vaccination is more than 3,000 yuan.

HPV vaccine has become a "trend", and women know more about their own development of

HPV vaccine. It can be said to be a milestone event in human fight against diseases - cervical cancer may become the only cancer in human history that can be "eliminated". However, due to various complex reasons, the vaccination process is also "some people are happy and some are worried."

"Now I think about it, people who can successfully get the nine-valent HPV vaccine are so lucky. I missed it twice." Chen Xin, who is currently 33 years old, said. The launch of the

HPV vaccine can be said to be a milestone in humans' fight against diseases. /Photo·unsplash

She explained that the first "missing" here was because she didn't know the existence of the nine-valent HPV vaccine before she was 26 years old; the second "missing" was because she went to Hong Kong to get the nine-valent HPV vaccine.

In 2019, she learned that her age was beyond the restrictions on the nine-valent HPV vaccine in mainland China, and she planned to travel to Hong Kong with her boyfriend and get vaccinated by the way.

This time, she spent a lot of money on getting vaccinated in Hong Kong. In addition to paying 3 shots of the vaccine at one time, the cost of HK$4,500 for each HPV vaccine needs to be 2 months or 6 months apart, she needs to purchase an additional round-trip air ticket worth tens of thousands of yuan each time, and bear the accommodation fee of at least one night and about 600 yuan.

Cervical cancer may become the only cancer in human history that can be "eliminated".

However, this plan was not implemented smoothly - after successfully receiving the first and second doses, the sudden and severe COVID-19 epidemic caused Chen Xin to be unable to go to Hong Kong for the third dose. She consulted many public and private hospitals in Beijing, Shanghai and Guangzhou, and the other party said that she could not help her get the third shot directly. Until now, Chen Xin has not successfully completed all vaccinations.

Now, Chen Xin is in the stage of pregnancy preparation and cannot receive any HPV vaccine. "But if I have the chance, I still hope to get the vaccine successfully after giving birth," she said.

In November 2020, World Health Organization (WHO) released the " Global Strategy for Accelerating the Elimination of Cervical Cancer ".

In November 2020, the World Health Organization (WHO) released the Global Strategy for Accelerating the Elimination of Cervical Cancer. By 2050, the three measures in the successful implementation of the strategy can reduce new cases and 50 million related deaths by more than 40%. These three measures include: 90% of girls complete HPV vaccination before the age of 15; 70% of women undergo efficient testing before the age of 35 and 45; and 90% of women diagnosed with cervical disease are treated.

This means that in addition to the HPV vaccination failure cases like Chen Xin, the idea of ​​blindly thinking that "to completely bid farewell to cervical cancer by vaccination" is also the reason for "failure" - if you want to "eliminate" cervical cancer, vaccine, screening, and treatment are indispensable.

Today's HPV vaccination has become a trend, which shows that the public health awareness of our people, especially women, is rapidly increasing.

However, on the positive side, as Huang Miao said, "HPV vaccination has become a trend today, which shows that the public health awareness of our people, especially women, is rapidly improving."

Compared with the previous "disagreement and avoidance of medical treatment" and "sexuality", more and more women can get HPV vaccine at the appropriate age. When they have symptoms of discomfort, they can also actively seek medical treatment. This is an important part of the awakening of women's self-rescue consciousness. Women are learning to care more about their health rights than the prejudice and gossip related to “sex”.